| U.S. surgeon | 12 |
| U.S. suffragist Lucy | 20 |
| U.S. Steel was once its biggest employer | 40 |
| U.S. Steel founder | 18 |
| U.S. stealth bomber (usually written with a numeral, but how about a little creative license?) | 94 |
| U.S. status during the Cuban Missile Crisis | 43 |
| U.S. station name retired in 1972 | 33 |
| U.S. statesman: 18th century | 28 |
| U.S. statesman who wrote "The Discipline of Power" | 60 |
| U.S. statesman known as ''The Great Compromiser'' | 65 |
| U.S. statesman Elbridge ___ | 27 |
| U.S. statesman and family | 25 |
| U.S. statesman | 14 |
| U.S. statehood entrant: 1907 | 28 |
| U.S. state with three counties | 30 |
| U.S. state with its own elec. power grid | 40 |
| U.S. state with a secessionist movement | 39 |
| U.S. state where prostitution is partly legal | 45 |
| U.S. state that comes first alphabetically: Abbr. | 49 |
| U.S. state since 1890 | 21 |
| U.S. state capital with fewer than 15,000 residents | 51 |
| U.S. state capital with 13,000 people | 37 |
| U.S. state | 10 |
| U.S. Star Wars program | 22 |
| U.S. stage name | 15 |
| U.S. stage group | 16 |
| U.S. spy satellite | 18 |
| U.S. spy org. | 13 |
| U.S. spy grp. | 13 |
| U.S. spy group | 14 |
| U.S. spy gp. | 12 |
| U.S. spy agency | 15 |
| U.S. sports org. | 16 |
| U.S. special investigator | 25 |
| U.S. Special Forces unit | 24 |
| U.S. spacecraft mission | 23 |
| U.S. spacecraft | 15 |
| U.S. space shuttle | 18 |
| U.S. space probe | 16 |
| U.S. space observatory | 22 |
| U.S. space booster | 18 |
| U.S. soprano Gluck | 18 |
| U.S. soldiers | 13 |
| U.S. soldier, personified | 25 |
| U.S. soldier in W.W. II | 23 |
| U.S. soldier | 12 |
| U.S. social reformer: 1849–1914 | 38 |
| U.S. soccer star Mathis et al. | 30 |
| U.S. soccer player with 158 international goals | 47 |
| U.S. Soc. of Sculptors site | 27 |
| U.S. slalom greats | 18 |
| U.S. slalom great Phil | 22 |
| U.S. slalom ace | 15 |
| U.S. sky eye | 12 |
| U.S. skater David ___ | 21 |
| U.S. singer-actor | 17 |
| U.S. ship transmuted | 20 |
| U.S. Shaker sect founder | 24 |
| U.S. servicewoman | 17 |
| U.S. senator's salary, e.g. | 31 |
| U.S. senator with the longest tenure in history | 47 |
| U.S. Senator from N.C.: 1954-74 | 31 |
| U.S. senator | 12 |
| U.S. Senate alumnus Sam | 23 |
| U.S. security, for short | 24 |
| U.S. security, briefly | 22 |
| U.S. security offering | 22 |
| U.S. Security investment | 24 |
| U.S. security | 13 |
| U.S. Secretary of State: 1898–1905 | 41 |
| U.S. secretary of state tied for the second-longest time in office | 66 |
| U.S. secretary of state raised in the Bronx | 43 |
| U.S. Secretary of State (1961-1969) | 35 |
| U.S. Sec. of War: 1829-31 | 25 |
| U.S. Sec. of State: 1905-9 | 26 |
| U.S. seaport founded in 1626 | 28 |
| U.S. sea-rescue group | 21 |
| U.S. sea arm | 12 |
| U.S. sculptor: 1898–1976 | 31 |
| U.S. sculptor of 1800's | 27 |
| U.S. sculptor | 13 |
| U.S. scientific satellite of the 60's | 41 |
| U.S. school near Juarez | 23 |
| U.S. scholastic org. | 20 |
| U.S. savings certificate | 24 |
| U.S. satellite of the '60s | 30 |
| U.S. satellite | 14 |
| U.S. Safeguard Program features | 31 |
| U.S. rocket with a name from Greek myth | 39 |
| U.S. rocket with a name from classical myth | 43 |
| U.S. rocket stage | 17 |
| U.S. rocket launched in 1961 | 28 |
| U.S. rocket | 11 |
| U.S. river or state | 19 |
| U.S. rights org. | 16 |
| U.S. rights defender | 20 |
| U.S. revolutionary Daniel ___ | 29 |
| U.S. retailer since 1902 | 24 |
| U.S. resort lake | 16 |
| U.S. resident's peers | 25 |