| ___ Island, Calif. | 18 |
| ___ Island, birthplace and longtime home of Cornelius Vanderbilt | 64 |
| ___ Island, Bahamas, boyhood home of 47A | 40 |
| ___ Island Sound | 16 |
| ___ Island Red (chicken) | 24 |
| ___ Island Red (chicken breed) | 30 |
| ___ Island Red | 14 |
| ___ Island National Wildlife Refuge, in Florida | 47 |
| ___ Island National Monument | 28 |
| ___ Island in the Pacific | 25 |
| ___ Island Ferry | 16 |
| ___ Island (site of New York City's largest jail facility) | 62 |
| ___ Island (site of a New York prison) | 38 |
| ___ Island (Puget Sound locale) | 31 |
| ___ Island (prison site) | 24 |
| ___ Island (onetime immigrants' arrival point) | 50 |
| ___ Island (NYC borough) | 24 |
| ___ Island (museum site) | 24 |
| ___ Island (lonely place on "Survivor") | 49 |
| ___ Island (location near Portland, Maine) | 42 |
| ___ Island (industrial area of Detroit) | 39 |
| ___ Island (immigration point) | 30 |
| ___ Island (immigrants' spot) | 33 |
| ___ Island (immigrants' site) | 33 |
| ___ Island (immigrants' arrival point) | 42 |
| ___ Island (former immigration checkpoint) | 42 |
| ___ Island (Brooklyn peninsula) | 31 |
| ___ Island ("Survivor" locale) | 40 |
| ___ Island ("Jaws" resort) | 36 |
| ___ Island | 10 |
| ___ Islam | 9 |
| ___ Ishii, character in "Kill Bill" | 45 |
| ___ Ishii ("Kill Bill" character) | 43 |
| ___ Isaacs Menken of stage fame | 31 |
| ___ is! | 7 |
| ___ is to say | 13 |
| ___ is human | 12 |
| ___ is cast | 11 |
| ___ Irvin, who designed the first cover for The New Yorker | 58 |
| ___ Irvin, longtime cartoonist for The New Yorker | 49 |
| ___ Irvin, classic cartoonist | 29 |
| ___ Irvin, classic artist for The New Yorker | 44 |
| ___ Irvan, 1991 winner at Daytona Beach | 39 |
| ___ irregular basis | 19 |
| ___ Iron Range (Minnesota) | 26 |
| ___ iron | 8 |
| ___ Irish Cream | 15 |
| ___ iris (Spanish for "rainbow") | 42 |
| ___ Irae | 8 |
| ___ ipsum (faux-Latin phrase frequently used by publishers in placeholder text blocks) | 86 |
| ___ ipsa loquitur (the thing speaks for itself) | 47 |
| ___ ipsa loquitur | 17 |
| ___ Iowa, Mississippi feeder | 28 |
| ___ Ionienne | 12 |
| ___ Invictus (Roman god) | 24 |
| ___ Investments (Boston-based financial company) | 48 |
| ___ Invalides (Paris landmark) | 30 |
| ___ Intrepid | 12 |
| ___ into tears (started crying) | 31 |
| ___ into holy matrimony | 23 |
| ___ into (pries) | 16 |
| ___ into (gets going) | 21 |
| ___ into (gets by chance) | 25 |
| ___ into (get started) | 22 |
| ___ into (attacks) | 18 |
| ___ into (attacks vigorously) | 29 |
| ___ into (attack strongly) | 26 |
| ___ into (assailed) | 19 |
| ___ into (assail) | 17 |
| ___ interview | 13 |
| ___ International, 1977 Nobel Peace Prize winner | 48 |
| ___ International Speedway | 26 |
| ___ International (human rights watchdogs) | 42 |
| ___ interference (baseball ruling) | 34 |
| ___ interface | 13 |
| ___ intents and purposes | 24 |
| ___ integra | 11 |
| ___ insurance | 13 |
| ___ insult to injury | 20 |
| ___ instrument | 14 |
| ___ instruction | 15 |
| ___ Institute, org. that makes use of the Allen Telescope Array | 63 |
| ___ Institute, in Brooklyn | 26 |
| ___ Institute, California retreat center for alternative education | 66 |
| ___ Institute for Biological Studies | 36 |
| ___ Institute (UFO-monitoring org.) | 35 |
| ___ Institute (D.C. think tank) | 31 |
| ___ Institute (Charles Koch's think tank) | 45 |
| ___ instincts | 13 |
| ___ instinct | 12 |
| ___ instant (very quickly) | 26 |
| ___ instant (swiftly) | 21 |
| ___ instant (suddenly) | 22 |
| ___ instant (right away) | 24 |
| ___ instant (quickly) | 21 |
| ___ instant (promptly) | 22 |
| ___ instant (immediately) | 25 |
| ___ instant (at once) | 21 |
| ___ instant | 11 |
| ___ Inside (store sign) | 23 |