| First Triumvirate member | 24 |
| First TV superstar Milton | 25 |
| First TV western series | 23 |
| First two in the first garden | 29 |
| First two-Nobel winner | 22 |
| First two-time Nobelist | 23 |
| First U.N. Secretary General | 28 |
| First U.S. ballistic missile | 28 |
| First U.S. chief justice | 24 |
| First U.S. coed college | 23 |
| First U.S. color TV maker | 25 |
| First U.S. color-TV maker | 25 |
| First U.S. multimillionaire | 27 |
| First U.S. poet laureate | 24 |
| First U.S. Postmaster General | 29 |
| First U.S. space station | 24 |
| First U.S. space traveler | 25 |
| First U.S. spacewalk mission | 28 |
| First U.S. vice president | 25 |
| First U.S. woman in space | 25 |
| First UN secretary-general | 26 |
| First unelected president | 25 |
| First US space station | 22 |
| First US vice president | 23 |
| First version of a film | 23 |
| First victim of fratricide | 26 |
| First victim of temptation | 26 |
| First victim's namesakes | 28 |
| First video arcade game | 23 |
| First Virginia in America | 25 |
| First Viscount Templewood | 25 |
| First voice of Mickey Mouse | 27 |
| First volume heading starter | 28 |
| First watch on the moon | 23 |
| First weather Satellites | 24 |
| First West German chancellor | 28 |
| First White House golfer | 24 |
| First White House occupant | 26 |
| First wife of Julius Caesar | 27 |
| First wife of Woodrow Wilson | 28 |
| First wireless telegrapher | 26 |
| First with headlight wipers | 27 |
| First Wives Club star | 24 |
| First woman attorney general | 28 |
| First woman elected governor | 28 |
| First woman in Parliament | 25 |
| First woman M.P. of England | 27 |
| First woman to govern a state | 29 |
| First woman, in Greek myth | 26 |
| First women's champ: 1946 | 29 |
| First word for a baby, maybe | 28 |
| First word in a Dickens title | 29 |
| First word in a fairy tale | 26 |
| First word in a Hugo title | 26 |
| First word in a Mozart title | 28 |
| First word in an Austen title | 29 |
| First word in crosswords? | 25 |
| First word in many addresses | 28 |
| First word in many letters | 26 |
| First word in many recipes | 26 |
| First word in many signs | 24 |
| First word in Mass. motto | 25 |
| First word in Vergil work | 25 |
| First word of The Raven | 26 |
| First word of a Carroll work | 28 |
| First word of a celebration | 27 |
| First word of a fairy tale | 26 |
| First word of a French motto | 28 |
| First word of a Latin epic | 26 |
| First word of a letter | 22 |
| First word of a limerick | 24 |
| First word of a Mozart title | 28 |
| First word of a Pacino film | 27 |
| First word of a popular hymn | 28 |
| First word of a quotation | 25 |
| First word of a seasonal poem | 29 |
| First word of an Austen title | 29 |
| First word of Declaration | 25 |
| First word of fairy tale | 24 |
| First word of many a letter | 27 |
| First word of many a script | 27 |
| First word of many a title | 26 |
| First word of many epitaphs | 27 |
| First word of many titles | 25 |
| First word of Mass. motto | 25 |
| First word of MGM's motto | 29 |
| First word of Moore poem | 24 |
| First word of motto of N.H. | 27 |
| First word of N. C. motto | 25 |
| First word of some sequels | 26 |
| First word of the Aeneid | 24 |
| First word of the Mass. motto | 29 |
| First word of two MLB teams | 27 |
| First word of Xmas poem | 23 |
| First word on a sash, often | 27 |
| First word on many spines | 25 |
| First words for Hamlet | 22 |
| First words from a dictator? | 28 |
| First words in Genesis | 22 |
| First words of a reprimand | 26 |