| First Republican President | 26 |
| First residence (last option) | 29 |
| First residence (option 1) | 26 |
| First residence (option 2) | 26 |
| First responder's skill | 27 |
| First responder, briefly | 24 |
| First responder, for short | 26 |
| First responder, maybe | 22 |
| First responder, often | 22 |
| First responder, perhaps | 24 |
| First responder, say: Abbr. | 27 |
| First responders (abbr.) | 24 |
| First responders, at times | 26 |
| First responders, briefly | 25 |
| First responders, for short | 27 |
| First responders: Abbr. | 23 |
| First response to a call | 24 |
| First rock from the sun | 23 |
| First Roman to be deified | 25 |
| First round pick of the Magic | 29 |
| First rule of lion taming? | 26 |
| First ruler of all Egypt | 24 |
| First ruler of the Slavs | 24 |
| First run of the still | 22 |
| First rung on a ladder | 22 |
| First Russian Orthodox saint | 28 |
| First Russian to orbit Earth | 28 |
| First schizophrenicproblem? | 28 |
| First schizophrenic problem? | 28 |
| First Seahawk quarterback Jim | 29 |
| First secretary of war | 22 |
| First section of a tome | 23 |
| First self-propelled spaceman | 29 |
| First semester offerings | 24 |
| First senator in space | 22 |
| First sergeant, informally | 26 |
| First set of wheels, maybe | 26 |
| First shepherd in the Bible | 27 |
| First shots in billiards | 24 |
| First showing of a film | 23 |
| First sign of the zodiac | 24 |
| First sign, astrologically | 26 |
| First site of Olympic games | 27 |
| First six-decade hockey pro | 27 |
| First Son of the '80s | 25 |
| First song on an album | 22 |
| First sound in an M-G-M film | 28 |
| First sound in an MGM movie | 27 |
| First sound in an SOS call | 26 |
| First sound of an MGM movie | 27 |
| First sound of impact? | 22 |
| First sound of silence? | 23 |
| First South Korean president | 28 |
| First spin: mixed fruit | 23 |
| First spoken word in Genesis | 28 |
| First st. with women voters | 27 |
| First stabber of Caesar | 23 |
| First stage of a study | 22 |
| First State's capital | 25 |
| First step in a hairdo | 22 |
| First step in a progression | 27 |
| First step in a series | 22 |
| First step in division? | 23 |
| First step toward nirvana | 25 |
| First Stephen King novel | 24 |
| First stock sale, for short | 27 |
| First stomach of a cow | 22 |
| First strip to win a Pulitzer | 29 |
| First stroke of a round | 23 |
| First subway line in N.Y.C. | 27 |
| First subway line in NYC | 24 |
| First successful video game | 27 |
| First Super Bowl M.V.P. | 23 |
| First Super Bowl rematch | 24 |
| First supersonic human | 22 |
| First survey datum, often | 25 |
| First Syd Barrett solo album | 28 |
| First symbol on a music line | 28 |
| First T. Rex hit in 1970 | 24 |
| First Tarzan portrayer | 22 |
| First term-limited pres. | 24 |
| First Thanksgiving hosts | 24 |
| First Thanksgiving locale | 25 |
| First three colors of rainbow | 29 |
| First three kinds of holes | 26 |
| First tiller or killer | 22 |
| First to arrive, often: Abbr. | 29 |
| First to be admitted?: Abbr. | 28 |
| First to break the tape | 23 |
| First to leave the blocks | 25 |
| First to move in chess | 22 |
| First to second, for one | 24 |
| First to see the sun, maybe | 27 |
| First to strike Caesar | 22 |
| First to swim Lake Ontario | 26 |
| First to take a ribbing | 23 |
| First to Third, in Germany | 26 |
| First transplant recipient | 26 |
| First Treasury secretary | 24 |
| First Triple Crown winner | 25 |