| First one-term president | 24 |
| First one-term U.S. president | 29 |
| First ones are special | 22 |
| First or final cut piece | 24 |
| First or financial follower | 27 |
| First or fore follower | 22 |
| First or foreign follower | 25 |
| First or second, e.g.: Abbr. | 28 |
| First or Second, in N.Y.C. | 26 |
| First or third baseman | 22 |
| First orbiting American | 23 |
| First Oscar-winner Jannings | 27 |
| First Oscar-winning film | 24 |
| First P.M. of modern India | 26 |
| First page of a calendario | 26 |
| First page of el calendario | 27 |
| First page of un calendario | 27 |
| First page on most sites | 24 |
| First part of a Florida city | 28 |
| First part of a musical | 23 |
| First part of a news story | 26 |
| First part of a one-two | 23 |
| First part of a proverb | 23 |
| First part of a question | 24 |
| First part of a record | 22 |
| First part of a riddle | 22 |
| First part of a series | 22 |
| First part of a signature | 25 |
| First part of a ski jump | 24 |
| First part of a tax form | 24 |
| First part of an Iowa city | 26 |
| First part of the joke | 22 |
| First part of the quip | 22 |
| First part of V.B.O.B. | 22 |
| First passage continued | 23 |
| First Peace Corps director | 26 |
| First peaceful protest? | 23 |
| First people from Manitoba | 26 |
| First periods in H.S., often | 28 |
| First person in ancient Rome | 28 |
| First person in Austria | 23 |
| First person in Berlin | 22 |
| First person in Berlin? | 23 |
| First person in France | 22 |
| First person in France? | 23 |
| First person in Frankfurt? | 26 |
| First person in Germany | 23 |
| First person in Germany? | 24 |
| First person in Potsdam | 23 |
| First person in the Bible | 25 |
| First person in Vienna | 22 |
| First person indicator | 22 |
| First person on a ship? | 23 |
| First person overseas? | 22 |
| First person present, e.g. | 26 |
| First person to be ribbed | 25 |
| First person to break Mach 1 | 28 |
| First person to fly a plane | 27 |
| First person, in Vienna | 23 |
| First Physics Nobelist | 22 |
| First piece of trial evidence | 29 |
| First pilot to exceed Mach 1 | 28 |
| First place award perhaps | 26 |
| First place of habitation | 25 |
| First place on a marquee | 24 |
| First planet, alphabetically | 28 |
| First player off the bench | 26 |
| First political organization? | 29 |
| First pope, in Catholicism | 26 |
| First popular sound cartoon | 27 |
| First portrayer of Obi-Wan | 26 |
| First pot contribution | 22 |
| First premier of China | 22 |
| First president of Angola | 25 |
| First president of Gabon | 24 |
| First president of Germany | 26 |
| First president of Indonesia | 28 |
| First president of Korea | 24 |
| First president of Mali | 23 |
| First president of S. Korea | 27 |
| First president of Tanzania | 27 |
| First president of the SCLC | 27 |
| First President Roosevelt | 25 |
| First presidential couple | 25 |
| First prime minister of Burma | 29 |
| First prime minister of Ghana | 29 |
| First prime minister of India | 29 |
| First principle of Kwanzaa | 26 |
| First prints of movies | 22 |
| First Prophet of Islam | 22 |
| First public appearance | 23 |
| First Puccini Turandot: 1926 | 28 |
| First Pulitzer Prize novelist | 29 |
| First quarter appearance | 24 |
| First queen of Carthage | 23 |
| First queen of Great Britain | 28 |
| First rabies vaccine creator | 28 |
| First radio code word? | 22 |
| First Reich for short | 22 |
| First Reich rulers: 936-1002 | 28 |