| First in a line of cars | 23 |
| First in a multi-volume set | 27 |
| First in a series of 26 | 23 |
| First in a string of 13 popes | 29 |
| First in a string of popes | 26 |
| First in double figures | 23 |
| First in line to the throne | 27 |
| First in line, perhaps | 22 |
| First in the film credits | 25 |
| First in the Hebrew alphabet | 28 |
| First in the waiting line | 25 |
| First Indian prime minister | 27 |
| First industrial revolution? | 28 |
| First instruction, often | 24 |
| First item on a certain table | 29 |
| First James Bond flick | 22 |
| First James Bond movie | 22 |
| First Japanese-Canadian MP | 26 |
| First job, for many teenagers | 29 |
| First king of modern Greece | 27 |
| First king of the English | 25 |
| First king of the Franks | 24 |
| First known variable star | 25 |
| First Korean president | 22 |
| First lady after Eleanor | 24 |
| First lady after Hillary | 24 |
| First Lady after Lady Bird | 26 |
| First lady before Abigail | 25 |
| First lady before Eleanor | 25 |
| First lady before Jackie | 24 |
| First lady before Mamie | 23 |
| First lady before Michelle | 26 |
| First Lady for 13 years | 23 |
| First lady from 1946 to 1952 | 28 |
| First Lady Grace's man | 26 |
| First lady in Parliament | 24 |
| First Lady of California | 24 |
| First lady of Jewish folklore | 29 |
| First Lady of Mount Olympus | 27 |
| First Lady of Song Fitzgerald | 29 |
| First lady of the 1910s | 23 |
| First Lady of the 1940s | 23 |
| First lady of the 1950s | 23 |
| First lady of the 1980s | 23 |
| First Lady of the 40's | 26 |
| First lady on Mount Olympus | 27 |
| First lady on Mt. Olympus | 25 |
| First lady played by Madonna | 28 |
| First lady ___ McKinley | 23 |
| First Lady's designation | 28 |
| First Lady's first name | 27 |
| First lady's garden | 23 |
| First lady's garden site? | 29 |
| First lady's home? | 22 |
| First lady's hype? | 22 |
| First lady's mate? | 22 |
| First lady's namesakes | 26 |
| First lady's residence | 26 |
| First lady's residence? | 27 |
| First Lady's title | 22 |
| First lady, May 7, 1988? | 24 |
| First lady, no kidding | 22 |
| First lady/pop star Carla | 25 |
| First landfall north of Oman | 28 |
| First law of motion subject | 27 |
| First layer of plaster | 22 |
| First letter in Bathsheba | 25 |
| First letter in Israel | 22 |
| First letter, in Hebrew | 23 |
| First letter, in signaling | 26 |
| First letter, to Aristotle | 26 |
| First line of a limerick | 24 |
| First line of a nursery rhyme | 29 |
| First line of a Seuss classic | 29 |
| First line of “Misty” | 29 |
| First line of many puns | 23 |
| First line on an IRS form? | 26 |
| First loyalty, to Polonius | 26 |
| First Lt.'s superior | 24 |
| First main Constitution part | 28 |
| First man on the scene | 22 |
| First man to walk in space | 26 |
| First man's sweeting? | 25 |
| First man, in Maori myth | 24 |
| First man, in Polynesian myth | 29 |
| First man-made satellite | 24 |
| First man-made textile fiber | 28 |
| First manager of the Mets | 25 |
| First manned mooncraft | 22 |
| First manned ship on the moon | 29 |
| First martyr in Christianity | 28 |
| First martyr, per Matthew | 25 |
| First mass-producer of cars | 27 |
| First mate of the Pequod | 24 |
| First mate's agreement | 26 |
| First mate's greeting? | 26 |
| First mate's reply | 22 |
| First meetings, briefly | 23 |
| First meson discovered | 22 |
| First Met to win a Gold Glove | 29 |