| Sir Isaac or Wayne | 18 |
| Sir Isaac who developed a shorthand method | 42 |
| Sir Isaac's will? | 21 |
| Sir Jagger | 10 |
| Sir James Biggers character | 27 |
| Sir James Dewar, for one | 24 |
| Sir James Galway, e.g. | 22 |
| Sir John Kenneth ___ (British composer) | 39 |
| Sir John ___, "Wonderland" illustrator | 48 |
| Sir John _____ | 14 |
| Sir John ______ | 15 |
| Sir Kingsley ___ | 16 |
| Sir Lancelot's armor | 24 |
| Sir Lancelot's protection | 29 |
| Sir Lancelot, proven in battle? | 31 |
| Sir Launcelot du ___ | 20 |
| Sir Laurence | 12 |
| Sir Lawrence ___-Tadema, English painter | 40 |
| Sir M. ___Newfoundlander we quote today | 39 |
| Sir Mackenzie _____ | 19 |
| Sir Michael | 11 |
| Sir Michael of "The Dark Knight Rises" | 48 |
| Sir Michael who plays Dumbledore | 32 |
| Sir Michael ___, modern composer | 32 |
| Sir Michael, the actor | 22 |
| Sir Mix-a-Lot anthem with the line "...don't want none unless you got buns, hon" | 94 |
| Sir Mix-a-Lot likes them, no lie | 32 |
| Sir Newton | 10 |
| Sir Newton, in situations of lower gravity | 42 |
| Sir of pop | 10 |
| Sir of song | 11 |
| Sir or Dame | 11 |
| Sir or Dame, e.g. | 17 |
| Sir or ma'am preceder | 25 |
| Sir or madam | 12 |
| Sir or madam, as the case may be | 32 |
| Sir or Madam, e.g. | 18 |
| Sir or Mrs. | 11 |
| Sir overseas | 12 |
| Sir Patrick of ballad fame | 26 |
| Sir Patrick of balladry | 23 |
| Sir Peter ___, painter of British royalty | 41 |
| Sir Richard Francis Burton was one | 34 |
| Sir Richard of "Camelot" | 34 |
| Sir Richard of The Tatler | 25 |
| Sir Richard who co-founded the Spectator | 40 |
| Sir Robert | 10 |
| Sir Robert and family | 21 |
| Sir Robert of London's bobbies | 34 |
| Sir Robert Peel repealed the last one in 1846 | 45 |
| Sir Robert Peel, for one | 24 |
| Sir Robert Peel, notably | 24 |
| Sir Robert ___ | 14 |
| Sir Robert's monuments | 26 |
| Sir Rudolph of opera | 20 |
| Sir Samuel | 10 |
| Sir Samuel Cunard and Sir Henry Royce | 37 |
| Sir Samuel ___ | 14 |
| Sir Stafford ___, British statesman | 35 |
| Sir Thomas | 10 |
| Sir Thomas the conductor | 25 |
| Sir Thomas More novel | 21 |
| Sir Thomas More work | 20 |
| Sir Thomas More, in Jordan | 26 |
| Sir Thomas who introduced the sonnet to England | 47 |
| Sir Thomas ___ | 14 |
| Sir Thomas, tea merchant | 24 |
| Sir Thomas, the writer | 22 |
| Sir Toby of "Twelfth Night" | 37 |
| Sir Topham ___ ("Thomas the Tank Engine" boss) | 56 |
| Sir Topham ___ ("Thomas the Tank Engine" manager) | 59 |
| Sir Trevor of the Royal Shakespeare Company | 43 |
| Sir Walter | 10 |
| Sir Walter and others | 21 |
| Sir Walter or N.C.'s capital | 32 |
| Sir Walter Raleigh quest | 24 |
| Sir Walter Scott character | 26 |
| Sir Walter Scott classic | 24 |
| Sir Walter Scott classic or Canadian car | 40 |
| Sir Walter Scott novel | 22 |
| Sir Walter Scott novel of 1817 | 30 |
| Sir Walter Scott work | 21 |
| Sir Walter ScottÂ’s first novel | 34 |
| Sir Walter was one | 18 |
| Sir Walter who wrote "Ivanhoe" | 40 |
| Sir Walter ___ | 14 |
| Sir Walter ___ (author) | 23 |
| Sir Walter ___, "Ivanhoe" author | 42 |
| Sir Walter, the novelist | 24 |
| Sir Wilfred ______ | 18 |
| Sir William of Canada | 21 |
| Sir William Wallace, for one | 28 |
| Sir William who wrote "The Principles and Practice of Medicine" | 73 |
| Sir William ___ (A founder of Johns Hopkins Hospital) | 53 |
| Sir William ___ (big name at Johns Hopkins Hospital) | 52 |
| Sir William ___ (one of Johns Hopkins Hospital's founders) | 62 |
| Sir Willoughby Patterne, e.g. | 29 |
| Sir __ Belch of "Twelfth Night" | 41 |
| Sir __ Guinness | 15 |
| Sir __ John | 11 |