| Single-celled organism | 22 |
| Single-celled organism (Var.) | 29 |
| Single-celled organism with a flagellum | 39 |
| Single-celled organism: var. | 28 |
| Single-celled organisms | 23 |
| Single-celled protozoa | 22 |
| Single-celled protozoan | 23 |
| Single-celled reproductive bodies | 33 |
| Single-channel | 14 |
| Single-combed fowl | 18 |
| Single-cut and rat-tail? | 24 |
| Single-dish meal | 16 |
| Single-edged knife | 18 |
| Single-edged sword | 18 |
| Single-edition mag | 18 |
| Single-entrance sts. | 20 |
| Single-file | 11 |
| Single-file marchers | 20 |
| Single-file travelers, at times | 31 |
| Single-foot | 11 |
| Single-foot and others | 22 |
| Single-foot and walk | 20 |
| Single-foot, e.g. | 17 |
| Single-grape wine | 17 |
| Single-gulp drink | 17 |
| Single-handed | 13 |
| Single-handedly | 15 |
| Single-helix compound | 21 |
| Single-helix molecule | 21 |
| Single-helix stuff | 18 |
| Single-issue magazine | 21 |
| Single-issue publication | 24 |
| Single-legged support | 21 |
| Single-malt datum | 17 |
| Single-malt liquor | 18 |
| Single-malt liquor store? | 25 |
| Single-masted boat | 18 |
| Single-masted boats | 19 |
| Single-masted sailboat | 22 |
| Single-masted sailer | 20 |
| Single-masted sailers | 21 |
| Single-masted sailing vessel | 28 |
| Single-masted ship | 18 |
| Single-masted vessel | 20 |
| Single-masted vessels | 21 |
| Single-master | 13 |
| Single-masters | 14 |
| Single-minded | 13 |
| Single-minded auditor | 21 |
| Single-minded captain | 21 |
| Single-minded people? | 21 |
| Single-minded person | 20 |
| Single-minded sort | 18 |
| Single-minded theorizer | 23 |
| Single-mindedness | 17 |
| Single-mom sitcom of the 2000s | 30 |
| Single-named "Hollywood Squares" regular | 50 |
| Single-named 1950s TV star | 26 |
| Single-named 60's singer | 28 |
| Single-named alt-rock artist | 28 |
| Single-named artist | 19 |
| Single-named British R&B singer | 35 |
| Single-named folk singer | 24 |
| Single-named folk singer from Alabama | 37 |
| Single-named folksinger | 23 |
| Single-named Irish singer | 25 |
| Single-named music star | 23 |
| Single-named New Age music star | 31 |
| Single-named New Age musician | 29 |
| Single-named New Age singer | 27 |
| Single-named nightclub star | 27 |
| Single-named novelist | 21 |
| Single-named singer | 19 |
| Single-named singer of the Velvet Underground | 45 |
| Single-named supermodel | 23 |
| Single-oared boats | 18 |
| Single-pan meal of Valencia | 27 |
| Single-person, as a band | 24 |
| Single-pip cards | 16 |
| Single-principle believer | 25 |
| Single-principle philosopher | 28 |
| Single-reed instrument | 22 |
| Single-season hit record holder | 31 |
| Single-season home-run king | 27 |
| Single-season RBI record-holder since 1930 | 42 |
| Single-season record holder for most HRs by a shortstop | 55 |
| Single-seeded fruit | 19 |
| Single-seeded fruits | 20 |
| Single-serve coffee maker insert | 32 |
| Single-serving coffee holder | 28 |
| Single-serving coffee option | 28 |
| Single-sex house, usually | 25 |
| Single-slab stone monuments | 27 |
| Single-speed bike feature | 25 |
| Single-stone column | 19 |
| Single-strand molecule | 22 |
| Single-stranded cell substance, often | 37 |
| Single-stranded molecule | 24 |
| Single-stripe GIs | 17 |
| Single-stroke point | 19 |