| Significant assets | 18 |
| Significant burst of air | 24 |
| Significant butter component | 28 |
| Significant courtroom figure | 28 |
| Significant creations | 21 |
| Significant danger to beef? | 27 |
| Significant degree | 18 |
| Significant degree? | 19 |
| Significant detail | 18 |
| Significant difference | 22 |
| Significant division | 20 |
| Significant drop-off | 20 |
| Significant dry spell? | 22 |
| Significant effect | 18 |
| Significant event | 17 |
| Significant events | 18 |
| Significant events outside the U.S.? | 36 |
| Significant feature | 19 |
| Significant hesitation | 22 |
| Significant historical span | 27 |
| Significant impressions | 23 |
| Significant music broadcast medium | 34 |
| Significant music industry market, nowadays | 43 |
| Significant one? | 16 |
| Significant ones? | 17 |
| Significant other | 17 |
| Significant other, e.g. | 23 |
| Significant other, in old slang | 31 |
| Significant other, in the gossip columns | 40 |
| Significant other, perhaps | 26 |
| Significant other, slangily | 27 |
| Significant others | 18 |
| Significant others, in modern parlance | 38 |
| Significant others? | 19 |
| Significant party of 1773 | 25 |
| Significant period | 18 |
| Significant period of time | 26 |
| Significant periods | 19 |
| Significant periods of history | 30 |
| Significant person? | 19 |
| Significant pile of stones | 26 |
| Significant showing | 19 |
| Significant source | 18 |
| Significant span | 16 |
| Significant spans | 17 |
| Significant stone | 17 |
| Significant stretch | 19 |
| Significant stretch of time | 27 |
| Significant stretches | 21 |
| Significant stretches of time | 29 |
| Significant time | 16 |
| Significant time in history | 27 |
| Significant time period | 23 |
| Significant time periods | 24 |
| Significant time spans | 22 |
| Significant times | 17 |
| Significant times in history | 28 |
| Significant timespans | 21 |
| Significant ___ | 15 |
| Significantly | 13 |
| Significantly diminish, as profits | 34 |
| Significantly diminishing, as profits | 37 |
| Significantly strengthens | 25 |
| Significantly underweight | 25 |
| Signification | 13 |
| Signified | 9 |
| Signifies | 9 |
| Signifies assent | 16 |
| Signifies respect and sadness | 29 |
| Signify | 7 |
| Signify assent | 14 |
| Signify yes | 11 |
| Signifying | 10 |
| Signifying, with "of" | 31 |
| Signing aid | 11 |
| Signing ape | 11 |
| Signing ceremony souvenirs | 26 |
| Signing choice | 14 |
| Signing gorilla | 15 |
| Signing illegally | 17 |
| Signing need | 12 |
| Signing needs | 13 |
| Signing off on | 14 |
| Signing place | 13 |
| Signing prompt | 14 |
| Signing-ceremony souvenir | 25 |
| Signmaker's tool | 20 |
| Signoff in a mash note | 22 |
| Signoff like "Truly," but shorter | 43 |
| Signor Ferrari | 14 |
| Signor Pavarotti, e.g. | 22 |
| Signor Ponti | 12 |
| Signora | 7 |
| Signora del Giocondo | 20 |
| Signora on a camel? | 19 |
| Signora Ponti | 13 |
| Signora's "Mangia!" | 33 |
| Signora's love | 18 |
| Signora's six | 17 |
| Signora, across the Alps | 24 |