| She played Laura Petrie, initially | 34 |
| She played Laurie Partridge | 27 |
| She played Lena Cole in the "Lethal Weapon" series | 60 |
| She played Leslie Howard's wife in "Intermezzo" | 61 |
| She played Lili Von Shtupp | 26 |
| She played Lilith on "Cheers" | 39 |
| She played Lily on "The Munsters" | 43 |
| She played Linda in "Arthur" | 38 |
| She played Lisa on "Green Acres" | 42 |
| She played Lois | 15 |
| She played Lois in "Lois & Clark" | 47 |
| She played Lois in "Superman" | 39 |
| She played Lois in "Superman" films | 45 |
| She played Lois on "Lois & Clark" | 47 |
| She played Lois opposite Christopher's Clark | 48 |
| She played Lola | 15 |
| She played Loretta in "Coal Miner's Daughter" | 59 |
| She played Lucinda in "Oscar and Lucinda" | 51 |
| She played Maerose in "Prizzi's Honor" | 52 |
| She played Maggie in "Pete Kelly's Blues" (1955) | 62 |
| She played Maid Marian in "Robin Hood," 1991 | 54 |
| She played Malcolm-Jamal Warner's sister | 44 |
| She played Mame | 15 |
| She played Margo in "All About Eve" | 45 |
| She played Maria Callas in 'Master Class' | 49 |
| She played Maria in "West Side Story" | 47 |
| She played Marilyn Miller | 25 |
| She played Marion in "Psycho" | 39 |
| She played Marnie | 17 |
| She played Martha in Broadway's "Who's Afraid of Virginia Woolf?" | 83 |
| She played Mary Hartman | 23 |
| She played Master Viper in "Kung Fu Panda" | 52 |
| She played Maude | 16 |
| She played Maude Findlay | 24 |
| She played Maude on "Maude" | 37 |
| She played Maxine on "Judging Amy" | 44 |
| She played Megan in "Funky Monkey" | 44 |
| She played Mia in "Pulp Fiction" | 42 |
| She played Michelle on "Full House" | 45 |
| She played Mindy | 16 |
| She played Miss Brooks | 22 |
| She played Molly in ''Ghost'' | 45 |
| She played Molly in "Ghost" | 37 |
| She played Mrs. Charles | 23 |
| She played Mrs. Garrett | 23 |
| She played Mrs. Garrett on both "Diff'rent Strokes" and "The Facts of Life" | 99 |
| She played Mrs. Gump in "Forrest Gump" | 48 |
| She played Mrs. Miniver in "Mrs. Miniver" | 51 |
| She played Mrs. Muir in the film "The Ghost and Mrs. Muir" | 68 |
| She played Mrs. Pynchon in "Lou Grant" | 48 |
| She played Mrs. Ted Baxter | 26 |
| She played Musette to Gish's Mimi in "La Boheme," 1926 | 68 |
| She played Myrlie in "Ghosts of Mississippi" | 54 |
| She played Nana in "Nana" | 35 |
| She played Natasha in "The Adventures of Rocky and Bullwinkle" | 72 |
| She played Nell in "Nell" | 35 |
| She played Nicole Chapman on "Fame" | 45 |
| She played Niles's wife on "Frasier" | 50 |
| She played Ninotchka | 20 |
| She played Nora Charles | 23 |
| She played Nora in "The Thin Man" | 43 |
| She played Nora to William's Nick | 37 |
| She played O'Shaughnessy opposite Bogart's Spade | 56 |
| She played Oda Mae in "Ghost" | 39 |
| She played Olive Madison opposite Struthers's Florence Ungar in a 1985 Broadway version of "The Odd Couple" | 121 |
| She played one of Charlie's Angels | 38 |
| She played one of Pierce's Bond girls in "Tomorrow Never Dies" | 76 |
| She played one of the Bundys | 28 |
| She played Pandora in "Pandora and the Flying Dutchman" | 65 |
| She played Phoebe's mom on "Friends" | 50 |
| She played Phoebe's mother on "Friends" | 53 |
| She played Phyllis on TV | 24 |
| She played Prue on "Charmed" | 38 |
| She played Rebecca Duvall playing Marilyn Monroe on "Smash" | 69 |
| She played Rebecca in the 1952 "Ivanhoe" | 50 |
| She played Rita in "Groundhog Day" | 44 |
| She played Romy in "Romy and Michele's High School Reunion" | 73 |
| She played Rose Nylund on "The Golden Girls" | 54 |
| She played Rosemary | 19 |
| She played Roxie on-screen | 26 |
| She played Roxy on "Dead Like Me" | 43 |
| She played Roz Doyle on "Frasier" | 43 |
| She played Roz on "Frasier" | 37 |
| She played Rudy on "The Cosby Show" | 45 |
| She played Sally in "When Harry Met Sally ..." | 56 |
| She played Sally in "When Harry Met Sally..." | 55 |
| She played Samantha on "Who's the Boss?" | 54 |
| She played Sandy in "Grease" | 38 |
| She played Sarah in "The Bible" | 41 |
| She played Sasha Monroe on "Third Watch" | 50 |
| She played Scarlett | 19 |
| She played Sean Penn's girlfriend in her film debut | 55 |
| She played Shirley's daughter in "Terms of Endearment" | 68 |
| She played Sidney in "Scream" | 39 |
| She played Sissy in "Urban Cowboy" | 44 |
| She played Sofia in "The Color Purple" | 48 |
| She played Sophie | 17 |
| She played Sophie in "Sophie's Choice" | 52 |
| She played Spike Lee's girlfriend in "Do the Right Thing" | 71 |
| She played Stella Johnson | 25 |