| Second sign on the music store door? | 36 |
| Second sinner | 13 |
| Second Sister | 13 |
| Second smallest continent | 25 |
| Second smallest continent, by size (abbr.) | 42 |
| Second smallest of the U.S.A. | 29 |
| Second smallest state: Abbr. | 28 |
| Second smallest Teletubby | 25 |
| Second sock, say | 16 |
| Second something | 16 |
| Second son | 10 |
| Second son of Adam | 18 |
| Second son of Jacob and Leah | 28 |
| Second son of Japheth | 21 |
| Second son of Judah | 19 |
| Second son of Noah | 18 |
| Second son of the first man | 27 |
| Second song on "Beatles '65" | 42 |
| Second sound? | 13 |
| Second spar | 11 |
| Second spin: close, but no cigar | 32 |
| Second stabs | 12 |
| Second star to be photographed | 30 |
| Second start | 12 |
| Second start? | 13 |
| Second starter | 14 |
| Second starter? | 15 |
| Second step | 11 |
| Second step for a marksman | 26 |
| Second step in a three-step cleansing process | 45 |
| Second stop in the Broadway song "We Open in Venice" | 62 |
| Second stories | 14 |
| Second story | 12 |
| Second story jobs | 17 |
| Second story London visitor | 27 |
| Second story? | 13 |
| Second string | 13 |
| Second stringers | 16 |
| Second summer blockbuster film, e.g.: Abbr. | 43 |
| Second Sunday before Lent | 25 |
| Second Sunday in May honoree | 28 |
| Second Sunday of May honoree | 28 |
| Second Super Bowl won by the Redskins | 37 |
| Second tel. line | 16 |
| Second thought leader | 21 |
| Second thoughts | 15 |
| Second three colors of rainbow | 30 |
| Second time around | 18 |
| Second time around? | 19 |
| Second time to the top | 22 |
| Second to none | 14 |
| Second to __ | 12 |
| Second to __ (the best) | 23 |
| Second to ___ | 13 |
| Second to ___ (the best) | 24 |
| Second to ___ (tops) | 20 |
| Second track on "Beatles '65" | 43 |
| Second transactions | 19 |
| Second trick | 12 |
| Second tries | 12 |
| Second tries on the set | 23 |
| Second tries, in cards | 22 |
| Second trimester test, for short | 32 |
| Second Triumvirate member | 25 |
| Second try on a movie shot | 26 |
| Second try with Ali | 19 |
| Second TV showing | 17 |
| Second U.S. astronaut in space, after Alan Shepard | 50 |
| Second U.S. President | 21 |
| Second up, Roberta ____ | 23 |
| Second variety of | 17 |
| Second vegetable course in a capital meal? | 42 |
| Second vending | 14 |
| Second verb in the Bible | 24 |
| Second version | 14 |
| Second versions | 15 |
| Second versions of stories | 26 |
| Second voice | 12 |
| Second wife in "The Good Earth" | 41 |
| Second wife of Aeneas | 21 |
| Second wife of Henry VIII | 25 |
| Second wife of Juan Peron | 25 |
| Second wife of Pericles | 23 |
| Second wife of Woodrow Wilson | 29 |
| Second wife's boy | 21 |
| Second wife, to the hubby's kids | 36 |
| Second winning number? | 22 |
| Second word from Descartes? | 27 |
| Second word in "Bohemian Rhapsody" | 44 |
| Second word in "The Raven" | 36 |
| Second word in a classic Whitman poem | 37 |
| Second word in a fairy tale | 27 |
| Second word in a Shakespeare title | 34 |
| Second word in a Wilder title | 29 |
| Second word in an anthem | 24 |
| Second word in Elvis's hit "Hound Dog" | 52 |
| Second word in fairy tales | 26 |
| Second word in many a fairy tale | 32 |
| Second word in many a limerick | 30 |
| Second word in many fairy tales | 31 |