| Second in a German series | 25 |
| Second in a Greek series | 24 |
| Second in a Latin series | 24 |
| Second in a series | 18 |
| Second in a series of sharp turns | 33 |
| Second in a series of Web postings | 34 |
| Second in a Sue Grafton series | 30 |
| Second in all-time hits | 23 |
| Second in cmd. | 14 |
| Second in command | 17 |
| Second in command in the state: Abbr. | 37 |
| Second in command, briefly | 26 |
| Second in command, informally | 29 |
| Second in command, maybe | 24 |
| Second in command, often | 24 |
| Second in command: abbr. | 24 |
| Second in command? | 18 |
| Second in court?: Abbr. | 23 |
| Second in crime | 15 |
| Second in evildoing | 19 |
| Second in line? | 15 |
| Second in order | 15 |
| Second in the credits, often | 28 |
| Second in the kitchen | 21 |
| Second indicator? | 17 |
| Second installment | 18 |
| Second introduction? | 20 |
| Second Israeli ambassador to the U.S. | 37 |
| Second Israeli ambassador to U.S. | 33 |
| Second issue? | 13 |
| Second Jimi Hendrix Experience album | 36 |
| Second job | 10 |
| Second lady after Tipper | 24 |
| Second Lady Biden | 17 |
| Second largest "Great Lake" | 37 |
| Second largest asteroid | 23 |
| Second largest bird | 19 |
| Second largest city in France | 29 |
| Second largest city in Italy | 28 |
| Second largest city in Japan | 28 |
| Second largest city in Nicaragua | 32 |
| Second largest city in the Czech Republic | 41 |
| Second largest European lake | 28 |
| Second largest Great Lake | 25 |
| Second largest Hawaiian Island | 30 |
| Second largest Islam denomination | 33 |
| Second largest island in the world | 34 |
| Second largest lake in Europe | 29 |
| Second largest of the Great Lakes | 34 |
| Second largest of 50 | 20 |
| Second largest of seven | 23 |
| Second largest of the Great Lakes | 33 |
| Second largest of the seven | 27 |
| Second largest planet | 21 |
| Second largest retailer in the U.S. | 35 |
| Second largest theater chain in the U.S. | 40 |
| Second leader | 13 |
| Second leg | 10 |
| Second letter | 13 |
| Second letter addendum | 22 |
| Second letter addendum: Abbr. | 29 |
| Second letter additions | 23 |
| Second letter after epsilon | 27 |
| Second letter afterthought | 26 |
| Second letter before iota | 25 |
| Second letter from Greece | 25 |
| Second letter of the Greek alphabet | 35 |
| Second letters of this puzzle's five theme answers (seen in order) | 70 |
| Second lieutenant, slangily | 27 |
| Second lieutenants | 18 |
| Second life | 11 |
| Second Life fan, e.g. | 21 |
| Second Life hookup | 18 |
| Second lightest element | 23 |
| Second line of a nursery rhyme? | 31 |
| Second line of pertinent rhyme | 30 |
| Second line of quip | 19 |
| Second line of quote | 20 |
| Second line of rhyme | 20 |
| Second line of the limerick | 27 |
| Second line of the verse | 24 |
| Second line of toast | 20 |
| Second line of verse | 20 |
| Second lodging | 14 |
| Second longest African river | 28 |
| Second longest river in Poland | 30 |
| Second looie | 12 |
| Second looies | 13 |
| Second look | 11 |
| Second look, on "Monday Night Football" | 49 |
| Second lt.'s equivalent | 27 |
| Second Lt.'s Navy equivalent | 32 |
| Second lt.'s subordinate | 28 |
| Second ltr. addenda | 19 |
| Second ltr. addendum | 20 |
| Second ltr. addition | 20 |
| Second man | 10 |
| Second man off Apollo 11 | 24 |
| Second man on the moon | 22 |
| Second man to walk on the moon | 30 |