| Señorita's silver | 24 |
| Señorita's snack | 23 |
| Señorita, say | 16 |
| Señor Guevara | 20 |
| Señor's assent | 25 |
| Señor's farewell | 27 |
| Señora Perón | 26 |
| Señora Peron | 19 |
| Señora's stewpot | 27 |
| Sebaceous | 9 |
| Sebaceous cyst | 14 |
| Sebaceous cysts | 15 |
| Sebaceous gland infection | 25 |
| Sebaceous gland problem | 23 |
| Sebaceous gland woe | 19 |
| Sebadoh "Open ___" | 28 |
| Sebadoh's Barlow | 20 |
| Sebastian Coe for one | 22 |
| Sebastian Coe rival | 19 |
| Sebastian Coe, e.g. | 19 |
| Sebastian Coe, for one | 22 |
| Sebastian of "Family Affair" | 38 |
| Sebastian of England | 20 |
| Sebastian of Skid Row | 21 |
| Sebastian of track fame | 23 |
| Sebastian who led London's bid for the 2012 Olympics | 56 |
| Sebastian who once ran the world's fastest mile | 51 |
| Sebastian ___, record-breaking miler | 36 |
| Sebastian's partner | 23 |
| Sebastian's sidekick | 24 |
| Sebastian's sister | 22 |
| Sebastian's twin | 20 |
| Sebastian's twin, in "Twelfth Night" | 50 |
| Sebastian, Bruce or John | 24 |
| Sebastiania seeds | 17 |
| Sebastián ___ (president of Chile beginning in 2010) | 55 |
| Seberg role: 1957 | 17 |
| Sec | 3 |
| SEC chairman ___ White | 22 |
| SEC concern | 11 |
| SEC founding member | 19 |
| SEC hiree, perhaps | 18 |
| SEC investigation target of 2005 | 32 |
| SEC investigation, maybe (3-6) | 30 |
| SEC member | 10 |
| SEC sch., to fans | 17 |
| SEC school | 10 |
| SEC school that retired Peyton Manning's number | 51 |
| Sec starter | 11 |
| SEC team | 8 |
| SEC team, to fans | 17 |
| Sec's partner? | 18 |
| Sec'y | 9 |
| Sec'y, e.g. | 15 |
| Sec'y, often | 16 |
| Sec, as wine | 12 |
| Sec. | 4 |
| Sec. addition to a signed letter | 32 |
| Sec. Brown's concern | 24 |
| Sec. Council member | 19 |
| Sec. Donovan's concern | 26 |
| Sec. Espy's Dept. | 21 |
| Sec. of Agriculture | 19 |
| Sec. of Agriculture: 1971–76 | 35 |
| Sec. of Commerce: 1969–72 | 32 |
| Sec. of Defense: 1969–72 | 31 |
| Sec. of Interior under F.D.R. | 29 |
| Sec. of State | 13 |
| Sec. of State after Vance | 25 |
| Sec. of State nickname | 22 |
| Sec. of State Powell, e.g. | 26 |
| Sec. of State under D.D.E. | 26 |
| Sec. of State who said "I am in control here" after Reagan was shot | 77 |
| Sec. of State's aide | 24 |
| Sec. of State, 1895–97 | 29 |
| Sec. of State: 1977 | 19 |
| Sec. of the Interior: 1933-46 | 29 |
| Sec. of the Interior: 1961–69 | 36 |
| Sec. of the Navy: 1906–8 | 31 |
| Sec. of the Navy: 1939–40 | 32 |
| Sec. of the Treasury | 20 |
| Sec. of Transportation | 22 |
| Sec. of War: 1829–31 | 27 |
| Sec. phone | 10 |
| Sec. Shultz's predecessor | 29 |
| Sec.'s blunder | 18 |
| Sec.-largest planet | 19 |
| Secant's reciprocal | 23 |
| Secant's reciprocal (Abbr.) | 31 |
| Secant's reciprocal: Abbr. | 30 |
| Secant's relative | 21 |
| Secant, e.g. | 12 |
| Secant, for one | 15 |
| Secants and cosecants | 21 |
| Secateurs | 9 |
| Secaucus clock setting | 22 |
| Secede from the Union, for example | 34 |
| Secession | 9 |
| Secession opponent | 18 |
| Secessionist | 12 |