| Upper limit of mineralogists' Mohs scale | 44 |
| Upper Lough ___, in Northern Ireland | 36 |
| Upper New York Bay's ___ Island | 35 |
| Upper part of a surveyor's transit | 38 |
| Upper part of an aircraft carrier | 33 |
| Upper regions of space, figuratively | 36 |
| Upper regions of space, poetically | 34 |
| Upper-crust sort, stereotypically | 33 |
| Upright Citizens Brigade segment | 32 |
| Upright part that connects stair treads | 39 |
| Upright, inscribed stone tablets | 32 |
| Uprising by children of the 1970s? Woof! | 40 |
| Uprisings at which CS gas may be used | 37 |
| Ups and downs of one's youth? | 33 |
| UPS deliveries requiring payment | 32 |
| Upscale car that's smooth on the road? | 42 |
| Upscale restaurant requirement, maybe | 37 |
| Upscale variety of coffee or chronic | 36 |
| Upscale wedding reception amenity | 33 |
| Upset the iron horse's course | 33 |
| Upset winner at the 1992 Kentucky Derby | 39 |
| Upset, with ''over'' | 36 |
| Upshot of Hanks or Hulce appearing in a turkey? | 47 |
| Upside down, lower case "e" | 37 |
| Upside-down guitar playing god, to fans | 39 |
| Upside-down lowercase "e" | 35 |
| Upstairs neighbor of Ralph and Alice | 36 |
| Upstart who makes insolent comments | 35 |
| Upstate New York city famous for silverware | 43 |
| Upstate New York town where I.B.M. was founded | 46 |
| Upstate New York's ___ Canal | 32 |
| Upsurge in business due to the Broncos? | 39 |
| Uptight accountant of "The Office" | 44 |
| Upton Sinclair title from Matthew | 33 |
| Upton who wrote "Oil!" | 32 |
| Uptown ballroom or Thameside hotel | 34 |
| Uptown's dir. in New York City | 34 |
| Upward curve of a ship's plank | 34 |
| Upward or downward social transition | 36 |
| Upwardly mobile Israeli company? | 32 |
| Uracil is one of its basic components | 37 |
| Urban alligator's home, they say | 36 |
| Urban area in a 1987 Cheech Marin film title | 44 |
| Urban area in a Cheech Marin film | 33 |
| Urban area populated by a minority group | 40 |
| Urban area set aside for pekoe purveyors? | 41 |
| Urban athlete's locale, in brief | 36 |
| Urban Dance Squad "(some) ___chat" | 44 |
| Urban financial area, informally | 32 |
| Urban legend about rapper Kanye? | 32 |
| Urban music genre with Jamaican and Latin roots | 47 |
| Urban Outfitters competitor, with "The" | 49 |
| Urban roar upset famous duelist (5,4) | 37 |
| Urban sidewalk vendor's offering | 36 |
| Urbanite with a view of Mt. Rainier | 35 |
| Urbanites who play three-card monte? | 36 |
| Urchin in Sherlock Holmes stories | 33 |
| Urge Overkill "Bottle of ___" | 39 |
| Urge Overkill "Tin ___" | 33 |
| Urge Overkill "___ the Dragon" | 40 |
| Urge to attack, with "on" | 35 |
| Urge to want to punch somebody, maybe | 37 |
| Urged (with ''on'') | 35 |
| Urgent messages from the precinct: Abbr. | 40 |
| Urgent need after a bite, at times | 34 |
| Urges to attack, with "on" | 36 |
| Urging to Stewart when feeling shy on the mic? | 46 |
| Urgings, as of one's conscience | 35 |
| Uriah in "The Greatest Story Ever Told" | 49 |
| Uriah of "David Copperfield" | 38 |
| Urich's ''Vega$'' role | 42 |
| Urich's role on "Vega$" | 37 |
| Urinating doll of the 1950s-60s ___ Wetsy | 41 |
| Uris novel ''___ 18'' | 37 |
| Uris novel "The _____" | 32 |
| Uris novel that's also a translucent quartz | 47 |
| Uris novel, with "The" | 32 |
| Uris who wrote "Exodus" | 33 |
| Uris who wrote "Redemption" | 37 |
| Uris's "_____ Pass" | 33 |
| Urkel of Family Matters for one | 39 |
| Ursula Andress, in "Dr. No" | 37 |
| Ursula of "The Blue Max" | 34 |
| Ursula who played Bond girl Vesper Lynd | 39 |
| Ursus ___ (scientific name for the brown bear) | 46 |
| Uruguayan novelist Juan Carlos ___ | 34 |
| US "A Study in Scarlet" setting | 41 |
| US agency that's got your number | 36 |
| US Army post at Huntsville, Alabama | 35 |
| US Govt. relief for the aged and disabled | 41 |
| US Interior Secretary of the '60s | 37 |
| US Open champ between John and Mats | 35 |
| US president who became a chief justice | 39 |
| US representative at the 1900 Paris Exposition | 46 |
| US Vice President born in Scranton | 34 |
| US Women's soccer star Krieger | 34 |
| US Women's Soccer star Rodriguez | 36 |
| US-stamp series subject of 1945-46 | 34 |
| USA national basketball team member Stoudemire | 46 |
| USA NETWORK rebranded to cover luxury travel? | 45 |