| 16-symbol system, for short | 27 |
| 16-team gridiron grp. | 21 |
| 16-team grp. | 12 |
| 16-time Gold Glove-winning pitcher Jim | 38 |
| 16-time medalist Michael | 24 |
| 16-time Oscar nominee | 21 |
| 16-time World Heavyweight Champion wrestler Flair | 49 |
| 16-year-old's desire | 24 |
| 16-year-old's want | 22 |
| 16-year-old, often | 18 |
| 16-year-old, typically | 22 |
| 16-year-olds, legally speaking | 30 |
| 16-yr.-old's desire, usually: Abbr. | 39 |
| 16.5 feet | 9 |
| 16.5 ft. in the Twilight Zone = | 31 |
| 160 sq. rd. units | 17 |
| 160 square rods | 15 |
| 160, once | 9 |
| 160, to Caesar | 14 |
| 1600 Pennsylvania Ave. residents | 32 |
| 1600 Pennsylvania Ave., e.g. | 28 |
| 1600 Pennsylvania Avenue residents | 34 |
| 1600 to 1800, on a boat | 23 |
| 1600's stargazer | 20 |
| 1600, in old Rome | 17 |
| 1600, to Caesar | 15 |
| 1600, to Cato | 13 |
| 1605 conspiracy led by Guy Fawkes | 33 |
| 1605 pope for 27 days | 21 |
| 1605, to Caesar | 15 |
| 1606 play of the Shakespeare apocrypha, with "The" | 60 |
| 1608 Monteverdi opera | 21 |
| 161, in old times | 17 |
| 1611 mutiny victim | 18 |
| 1618-'48 conflict | 21 |
| 162 major league baseball games | 31 |
| 1620 craft | 10 |
| 1620 ship | 9 |
| 164-foot-tall movie star | 24 |
| 1650, in Roman numerals | 23 |
| 1650, to Caesar | 15 |
| 16501 | 5 |
| 1655 conqueror of New Sweden | 28 |
| 1664 John Evelyn forestry text | 30 |
| 1666 London fire chronicler | 27 |
| 1669 blast site | 15 |
| 1669 Louis Jolliet discovery | 28 |
| 1669 sight for Louis Jolliet | 28 |
| 1674 architect of Theatre Royal, Drury Lane | 43 |
| 1676 Virginia uprising | 22 |
| 1677 Racine tragedy | 19 |
| 168 hours | 9 |
| 168 in a wk | 11 |
| 168 in a wk. | 12 |
| 168 straight hours | 18 |
| 1690s Massachusetts witch hunt locale | 37 |
| 1690s witchcraft town | 21 |
| 1692 trial site | 15 |
| 1692 trials locale | 18 |
| 1692 trials site | 16 |
| 1692 witch trials city | 22 |
| 1692 witch trials setting | 25 |
| 16:9, say | 9 |
| 16½ feet | 11 |
| 16th alphabet letter | 20 |
| 16th c. chronicler of Italian art | 33 |
| 16th C. ecumenical council | 26 |
| 16th C. hat | 11 |
| 16th C. poet | 12 |
| 16th century British statesman | 30 |
| 16th century church council site | 32 |
| 16th century council site | 25 |
| 16th century dramatist Thomas | 29 |
| 16th century Italian poet | 25 |
| 16th century painter Veronese | 29 |
| 16th century Span. Carmelite reformer | 37 |
| 16th century's end | 22 |
| 16th Greek letter | 17 |
| 16th in a series | 16 |
| 16th letter of the Spanish alphabet | 35 |
| 16th letters in Hebrew | 22 |
| 16th president familiarly | 26 |
| 16th president's nickname | 29 |
| 16th president, familiarly | 26 |
| 16th president, informally | 26 |
| 16th prez | 9 |
| 16th seed's bracket win, e.g. | 33 |
| 16th- and 17th-century entertainment in England | 47 |
| 16th-17th-century Mughal Empire capital | 39 |
| 16th-century architect, Tuileries builder | 41 |
| 16th-century artist Veronese | 28 |
| 16th-century assembly | 21 |
| 16th-century bowed stringed instrument | 38 |
| 16th-century circumnavigator | 28 |
| 16th-century council city | 25 |
| 16th-century council site | 25 |
| 16th-century dance | 18 |
| 16th-century date | 17 |
| 16th-century Ecumenical Council site | 36 |
| 16th-century English architectural style | 40 |