| First female director of U.S. Mint | 34 |
| First female dean of Harvard Law School | 39 |
| First female chancellor of Germany | 34 |
| First female candidate to win the Ames Straw Poll | 49 |
| First female athlete to host "SNL" | 44 |
| First female appointed to our Supreme Court | 43 |
| First felony conviction, in some states | 39 |
| First farmers to use yoked teams? | 33 |
| First family when the Titanic sank | 34 |
| First family of the early 20th century | 38 |
| First Family of Hawaii: 1900–03 | 38 |
| First family of Germany, 1969-74 | 32 |
| First Family of Alaska in the 60's | 38 |
| First Families of Virginia surname | 34 |
| First European to reach the Pacific | 35 |
| First European to reach New Zealand | 35 |
| First European to reach India by sea | 36 |
| First European to land in North America | 39 |
| First European to enter New York Bay | 36 |
| First European to discover Tahiti | 33 |
| First European to discover Alaska | 33 |
| First European to cross the Mississippi | 39 |
| First European on Prince Edward Island | 38 |
| First European nation to win the World Cup | 42 |
| First European explorer to see New Zealand | 42 |
| First entry in a crossword to a constructor | 43 |
| First English commander to see the Pacific | 42 |
| First English child born in America | 35 |
| First elected member at Cooperstown | 35 |
| First elected governor of Alaska | 32 |
| First elected Congresswoman Jeannette | 37 |
| First editor of The Atlantic Monthly | 36 |
| First editor of "The Overland Monthly" | 48 |
| First Dynasty in Chinese history | 32 |
| First drug approved to treat AIDS | 33 |
| First drink ever ordered by James Bond | 38 |
| First drawer of the Democratic donkey | 37 |
| First double, and first female, Nobelist | 40 |
| First Dominican manager in the major leagues | 44 |
| First Dominican manager in MLB history | 38 |
| First Dominican major-league manager | 36 |
| First Dodge with front-wheel drive | 34 |
| First distiller to sell whiskey by the bottle | 45 |
| First director of the U.S. Peace Corps | 38 |
| First digit in an Alaskan zip code | 34 |
| First digit in a Hawaiian zip code | 34 |
| First digit in a California zip code | 36 |
| First digit a toddler is taught, often | 38 |
| First designated spot at a swim meet, perhaps | 45 |
| First defenseman to lead N.H.L. in scoring | 42 |
| First day of the rest of your life | 34 |
| First day of the month, in ancient Rome | 39 |
| First day of spring, to Vietnamese | 34 |
| First day of Lent: ___ Wednesday | 32 |
| First Daughter of the late 1970s | 32 |
| First daughter in the Carter White House | 40 |
| First dark horse elected U.S. President | 39 |
| First cut on the album "Sticky Fingers" | 49 |
| First customer for the Boeing 787 | 33 |
| First couture house to make a designer sports car | 49 |
| First cousin of Princes William and Harry | 41 |
| First course option on a North African menu? | 44 |
| First course dish in a trattoria, at times | 42 |
| First course at a German restaurant, maybe | 42 |
| First Council of Nicaea formulation | 35 |
| First correct "Hollywood Squares" spot | 48 |
| First corner after "Go" in Monopoly | 45 |
| First conspirator to stab Caesar | 32 |
| First computer to predict a U.S. election outcome | 49 |
| First computer language used for embedded systems | 49 |
| First compass point, alphabetically | 35 |
| First company to sell soft contact lenses | 41 |
| First commercially successful computer | 38 |
| First commercial carrier to use the Boeing 747 | 46 |
| First comment from a certain doctor? | 36 |
| First coml. airline to show in-flight movies | 44 |
| First comes love, then these three | 34 |
| First comes love, then these four | 33 |
| First comes love, then comes these two | 38 |
| First comes love, then comes these three | 40 |
| First class, briefly, for some kids | 35 |
| First city bombed in W.W. II's Baedeker Blitz | 49 |
| First circle on a Scantron sheet, often | 39 |
| First CinemaScope film (With "The") | 45 |
| First cigarette brand to introduce filters | 42 |
| First chronicled Chinese dynasty | 32 |
| First Chief Justice of the United States | 40 |
| First character to appear in "Carmen" | 47 |
| First character seen in "Zelig" | 41 |
| First chancellor of West Germany | 32 |
| First celebrity on "Sesame Street" | 44 |
| First Catholic vice president of the U.S. | 41 |
| First card turned up in a game of faro | 38 |
| First card played in the game parliament | 40 |
| First capital of the Last Frontier | 34 |
| First capital of the kingdom of Italy | 37 |
| First canonized native-born American | 36 |
| First Canadian-born Governor General | 36 |
| First Canadian woman atop Everest | 33 |
| First Canadian winner at Augusta | 32 |