| First Lady who went to Harvard Law School | 41 |
| First lady who was once a prominent radio actress | 49 |
| First lady of the United States (1963-1969) | 43 |
| First lady of the United States (1953-1961) | 43 |
| First lady of the United States (1861-1865) | 43 |
| First Lady Lou Hoover, ___ Henry | 32 |
| First lady between Frances and Edith | 36 |
| First lady between Eleanor and Mamie | 36 |
| First lady between Bess and Jackie | 34 |
| First lady and diplomat Roosevelt | 33 |
| First Labor P.M. to win consecutive terms | 41 |
| First knuckleballer to win the Cy Young | 39 |
| First known European to reach New Zealand | 41 |
| First king of Iraq: 1921–33 | 34 |
| First king buried in Westminster Abbey | 38 |
| First Kentucky Derby winner: 1875 | 33 |
| First job title, for many teenagers | 35 |
| First Jewish superstar in the major leagues | 43 |
| First jazz musician to win a Pulitzer Prize | 43 |
| First Japanese-American congressman Daniel | 42 |
| First Japanese prime minister born after WWII | 45 |
| First Japanese golfer to win a PGA Tour event | 45 |
| First Japanese car to be produced in the U.S. | 45 |
| First Israeli ambassador to the UN | 34 |
| First Israeli ambassador to the U.N. | 36 |
| First Irishman to win a Nobel Prize | 35 |
| First insurer to advertise on television | 40 |
| First instruction in many a homework assignment | 47 |
| First installment of a miniseries | 33 |
| First initial + last name, often | 32 |
| First inductee into the Baseball Hall of Fame | 45 |
| First Indian tribe met by Lewis and Clark | 41 |
| First Indian ruler to embrace Buddhism | 38 |
| First in line for the throne, maybe | 35 |
| First in a series of Web postings | 33 |
| First in a series of slasher flicks | 35 |
| First in a popular horror movie franchise | 41 |
| First in a long line of sitcoms? | 32 |
| First in a line of Russian grand princes | 40 |
| First in a John Updike novel series | 35 |
| First in a horror film franchise | 32 |
| First human born, according to the Bible | 40 |
| First host of "The Family Feud" | 41 |
| First host of "Jeopardy!" | 35 |
| First horse to win the Triple Crown | 35 |
| First Honorary Reagan Fellow of Eureka College | 46 |
| First home of the University of Nevada | 38 |
| First high priest of the Hebrews | 32 |
| First Hebrew letter, in some transliterations | 45 |
| First hard rock band to score a #1 country hit | 46 |
| First half of things we all memorized | 37 |
| First half of an indirect course? | 33 |
| First half of an ice cream flavor | 33 |
| First half of an attention-getter | 33 |
| First half of a lose-lose comment | 33 |
| First half of a Little Richard song title | 41 |
| First half of a famous Park Avenue hotel name | 45 |
| First half of a Beatles song title | 34 |
| First hair remover to be marketed in cream form | 47 |
| First H.E.W. Secretary ___ Culp Hobby | 37 |
| First Greek-American vice president | 35 |
| First great master of the symphony | 34 |
| First Great Lake, alphabetically | 32 |
| First Grammy Lifetime Achievement awardee | 41 |
| First Grammy Lifetime Achievement Award winner | 46 |
| First governor of Va., Baron ___ Warr | 37 |
| First governor of the state of Alaska | 37 |
| First governor of the 49th state | 32 |
| First governor of Russian America | 33 |
| First governor of "The 49th" | 38 |
| First golfer to win all four majors | 35 |
| First German to be Roman Emperor | 32 |
| First generation Japanese-Americans | 35 |
| First generation Japanese-American | 34 |
| First generation Japanese immigrants | 36 |
| First game of a Chinese double-header? | 38 |
| First G.O.P. presidential candidate | 35 |
| First free Internet service provider | 36 |
| First foreign World Series winner | 33 |
| First foreign LPGA championship winner | 38 |
| First five-time Super Bowl champs | 33 |
| First first name in Olympic gymnastic tens | 42 |
| First first lady in the White House | 35 |
| First First Family of the Weimar Republic | 41 |
| First film to gross $100 million | 32 |
| First film in CinemaScope, with "The" | 47 |
| First film critic to win a Pulitzer | 35 |
| First filly to win the Kentucky Derby | 37 |
| First fifth of a Shakespeare play | 33 |
| First female U.S. attorney general | 34 |
| First female to swim the Channel | 32 |
| First female Supreme Court Justice | 34 |
| First female Speaker of the House | 33 |
| First female speaker of Canada's parliament | 47 |
| First female Secretary of the Interior (2001-06) | 48 |
| First female professor at the University of Paris | 49 |
| First female member of the British Parliament | 45 |
| First female member of Parliament | 33 |
| First female Mayor of a Canadian city | 37 |
| First female director of U.S. Mint: 1933 | 40 |