| First prime minister of India or jacket style | 45 |
| First prime minister of Great Britain | 37 |
| First prime minister of free India | 34 |
| First president with a Twitter account | 38 |
| First president who wasn't elected | 38 |
| First president who was the son of a president | 46 |
| First president to throw an Opening Day pitch | 45 |
| First president to take office by succession | 44 |
| First president to occupy the White House | 41 |
| First president to occupy the Oval Office | 41 |
| First president to marry while in office | 40 |
| First president to live in the White House | 42 |
| First president to have a veto overridden | 41 |
| First president to get married while in office | 46 |
| First president to file an income tax return | 44 |
| First president of the Transvaal | 32 |
| First president of the Sierra Club | 34 |
| First president of the German republic, 1919 | 44 |
| First president of the Czech Republic | 37 |
| First president of the 20th century | 35 |
| First president of League of Women Voters | 41 |
| First president of Czechoslovakia | 33 |
| First president not born in the continental U.S. | 48 |
| First president born outside the continental U.S. | 49 |
| First president born in the 19th century | 40 |
| First pres. to visit China while in office | 42 |
| First Pres. born west of the Mississippi | 40 |
| First possible inning for a walk-off homer | 42 |
| First popular song that won an Emmy | 35 |
| First pope with the title "the Great" | 47 |
| First pope to be called "the Great" | 45 |
| First pope in a baker's dozen | 33 |
| First pope called "the Great" | 39 |
| First poet to use the terza rima verse form | 43 |
| First poet to read at a presidential inauguration | 49 |
| First player to win tennis's Grand Slam | 43 |
| First player listed in "Total Baseball" | 49 |
| First player elected to the Baseball Hall of Fame | 49 |
| First planet discovered using a telescope | 41 |
| First pitcher to record 5,000 career strikeouts | 47 |
| First piece of evidence presented at trial | 42 |
| First pianist to use a jazz organ | 33 |
| First philosopher to mention Atlantis | 37 |
| First PGA player to shoot his age, with a 67 | 44 |
| First person you see at some fine restaurants | 45 |
| First person with two Nobel Prizes | 34 |
| First person to travel faster than sound | 40 |
| First person to reach the North and South Poles | 47 |
| First part of the waiter's reply | 36 |
| First part of psychosexual development | 38 |
| First part of diner's complaint | 35 |
| First part of an entertaining thought | 37 |
| First part of a quote by Aristotle | 34 |
| First part of a Latin conjugation | 33 |
| First part of a hit for this crossword | 38 |
| First part of a Harvey Pekar quote | 34 |
| First part of a Groucho Marx comment | 36 |
| First part of a form to fill out | 32 |
| First part of a Caesarean declaration | 37 |
| First part of "The Divine Comedy" | 43 |
| First overall pick of the 2007 NHL draft | 40 |
| First overall pick in the 2004 NFL draft | 40 |
| First Oscar winner for animated films | 37 |
| First Oscar winner for Animated Feature | 39 |
| First order of Greek architecture | 33 |
| First orange property on a Monopoly board | 41 |
| First or third quarter phenomenon | 33 |
| First or third "T" in "TW3" | 47 |
| First or second word of Karen O's band name | 47 |
| First or second number in the Fibonacci sequence | 48 |
| First or last name in the Baseball Hall of Fame | 47 |
| First or last digit of D.C.'s area code | 43 |
| First opera in which Pavarotti appeared | 39 |
| First one out in "The Contest" | 40 |
| First Olympics venue with women's hockey | 44 |
| First Olympic venue for giant slalom | 36 |
| First Olympic Hall of Fame gymnast | 34 |
| First Olympic gymnast to receive a 10 | 37 |
| First official act at Super Bowl | 32 |
| First off-shore driller, in 1947 | 32 |
| First of two before-and-after pictures | 38 |
| First of three in a pencil/paper game | 37 |
| First of three consecutive rhyming letters | 42 |
| First of the year in Mexico City | 32 |
| First of the two sisters Jacob married | 38 |
| First of the Pevensie children to visit Narnia | 46 |
| First of the major Hebrew prophets | 34 |
| First of the Biblical high priests | 34 |
| First of the Astaire-Rogers films: 1933 | 39 |
| First of nine in "Strange Interlude" | 46 |
| First of many body parts in "Alouette" | 48 |
| First of four Holy Roman emperors | 33 |
| First of four Chuck Noll championships | 38 |
| First of five in "Hamlet" | 35 |
| First of England's Stuart kings | 35 |
| First of a planned 26-book mystery series | 41 |
| First of a journalist's five W's | 40 |
| First of a Hope-Crosby film series | 34 |
| First of 12 popes with a religious-sounding name | 48 |
| First of "The Chronicles of Clovis" | 45 |