| ___ splints (jogger's complaint) | 36 |
| ___ Spiegel (Hamburger's rag) | 33 |
| ___ Spiegel (German newsmagazine) | 33 |
| ___ Spice (nickname for Victoria Beckham) | 41 |
| ___ spheroid (football, to sports writers) | 42 |
| ___ Spencer, brother of Princess Diana | 38 |
| ___ Speedy (rival of Kinko's) | 33 |
| ___ Speedwagon (1970s-'80s band) | 36 |
| ___ Specter (Pennsylvania senator for 30 years) | 47 |
| ___ Spark, creator of Miss Jean Brodie | 38 |
| ___ Spalko, Indiana Jones villainess | 36 |
| ___ spades (highest card in a deck) | 35 |
| ___ Southwest Grill (restaurant chain) | 38 |
| ___ soup (starter at a Japanese restaurant) | 43 |
| ___ Sound (Washington estuarine system) | 39 |
| ___ Sorensen, "Kennedy" author | 40 |
| ___ Sophia, church built by Justinian | 37 |
| ___ someone's eyes (deceive) | 32 |
| ___ solution (contact lens wash) | 32 |
| ___ Solo of "Star Wars" | 33 |
| ___ Solo ("Star Wars" character) | 42 |
| ___ soit qui mal y pense (old motto) | 36 |
| ___ soit qui mal y pense (classic motto) | 40 |
| ___ Soft (major video game developer, once) | 43 |
| ___ Soetoro (Obama's stepfather) | 36 |
| ___ Society (super-high I.Q. group) | 35 |
| ___ Society (English debating group) | 36 |
| ___ snag (experience difficulty) | 32 |
| ___ Smith, who won the 1972 Wimbledon | 37 |
| ___ Smiley of "Sesame Street" | 39 |
| ___ smear (annual exam for some) | 32 |
| ___ Sloper (1915 Grand National winner) | 39 |
| ___ slip (certain wardrobe malfunction) | 39 |
| ___ Skywalker of "Star Wars" | 38 |
| ___ Skye (Donovan's daughter) | 33 |
| ___ Skip Day (high-school celebration of truancy) | 49 |
| ___ Sketch (popular drawing toy) | 32 |
| ___ sketch (concise description) | 32 |
| ___ Sketch (classic drawing toy) | 32 |
| ___ Sisters of "Macbeth" | 34 |
| ___ Sisters (Shakespearean witches) | 35 |
| ___ Sisters (daughters of Atlas) | 32 |
| ___ Simpson, Southern Open champ: 1985 | 38 |
| ___ Simbel, historic site in Egypt | 34 |
| ___ Simbel, historic Egyptian site | 34 |
| ___ Simbel (Egyptian temple site) | 33 |
| ___ Silvia, mother of Romulus and Remus | 39 |
| ___ silver (1890s political issue) | 34 |
| ___ Silence, 1989 Kentucky Derby winner | 39 |
| ___ signum (look at the proof: Lat.) | 36 |
| ___ shrimp (what Sea-Monkeys are) | 33 |
| ___ shrdlu (printer's error) | 32 |
| ___ shot (drummer's quickie) | 32 |
| ___ Shop Boys ("West End Girls" band) | 47 |
| ___ Shop Boys ("Go West" band) | 40 |
| ___ shoestring (with little to spend) | 37 |
| ___ shirt (colorful short-sleeved attire) | 41 |
| ___ Shinrikyo (Japanese cult in 1995 news) | 42 |
| ___ shift (newspaper's night relay) | 39 |
| ___ sheet (builder's instructions) | 38 |
| ___ Sharp, founder of Four Seasons Hotels | 41 |
| ___ Shan (National Zoo panda born in 2005) | 42 |
| ___ shadow of one's former self | 35 |
| ___ Settlements, former British colony | 38 |
| ___ Seton, author of "My Theodosia" | 45 |
| ___ Seton, author of "Dragonwyck" | 43 |
| ___ Seton, "My Theodosia" author | 42 |
| ___ Seton, "Dragonwyck" author | 40 |
| ___ set (future engineer's toy) | 35 |
| ___ service (promoter's strength) | 37 |
| ___ server (site from which to download) | 40 |
| ___ Seri Begawan (Brunei's capital) | 39 |
| ___ septal defect (heart problem) | 33 |
| ___ segno (from the sign in music) | 34 |
| ___ segno (from the repeat sign, in music) | 42 |
| ___ seeds, ingredients in some health drinks | 44 |
| ___ Sec. of the Navy (F.D.R.: 1913-20) | 38 |
| ___ sec. (minutes keeper, for short) | 36 |
| ___ seat (revival-meeting bench) | 32 |
| ___ Search (former name for Bing) | 33 |
| ___ Seal (weatherproofing product) | 34 |
| ___ Sea, waters depleted by irrigation projects | 47 |
| ___ Sea, south of the Philippines | 33 |
| ___ Sea, outlet of the Amu Darya | 32 |
| ___ Sea, outlet for the Amu Darya | 33 |
| ___ Sea, next to the Philippines | 32 |
| ___ Sea, near the Greater Barsuki Desert | 40 |
| ___ Sea, modern site of ship graveyards | 39 |
| ___ Sea, lake in southern Calif. | 32 |
| ___ Sea, known in ancient times as Oxianus Lacus | 48 |
| ___ Sea, home of the Isle of Man | 32 |
| ___ Sea, east of the Ustyurt Plateau | 36 |
| ___ Sea, connected to St. George's Channel | 46 |
| ___ Sea, body of water south of Italy | 37 |
| ___ Sea, body of water north of Norway | 38 |
| ___ Sea, arm of the Indian Ocean | 32 |
| ___ Sea, arm of the Arctic Ocean | 32 |
| ___ Sea, 2,000-square-mile saltwater lake | 41 |
| ___ Sea of California's Sonoran Desert | 42 |
| ___ Sea between Ireland and England | 35 |