| Down with the flu, e.g. | 23 |
| Down with the flu, say | 22 |
| Down ___ (Maine nickname) | 25 |
| Down ___ (New England) | 22 |
| Down's opposite: Abbr. | 26 |
| Down, with "up"? | 26 |
| Down-and-out time-out? | 22 |
| Down-and-outer's district | 29 |
| Down-and-outer's milieu | 27 |
| Down-easter's home | 22 |
| Down-easter's state | 23 |
| Down-for-the-count count | 24 |
| Down-for-the-count counter | 26 |
| Down-home breakfast serving | 27 |
| Down-home entertainment | 23 |
| Down-in-the-mouth look | 22 |
| Down-in-the-mouth org.? | 23 |
| Down-in-the-mouth sort? | 23 |
| Down-shifted into second? | 25 |
| Down-to-earth greeting | 22 |
| Down-to-earth ones, in brief? | 29 |
| Down-to-___ (unpretentious) | 27 |
| Down-under 10-point game tile | 29 |
| Down-under jumpers, briefly | 27 |
| Downbeat Gloria Swanson film? | 29 |
| Downbeat in a bar of music | 26 |
| Downed power lines, e.g. | 24 |
| Downed Russian orbiter | 22 |
| Downed Russian space station | 28 |
| Downey's TV co-star | 23 |
| Downfall that some dread | 24 |
| Downhill/uphill conveyance | 26 |
| Downhiller's accessory | 26 |
| Downhiller's activity | 25 |
| Downhiller's applications | 29 |
| Downhiller's sport | 22 |
| Downing and Main (Abbr.) | 24 |
| Downing and others (abbr.) | 26 |
| Downing and others, briefly | 27 |
| Downing and others: Abbr. | 25 |
| Downing St. number of note | 26 |
| Downing St. V.I.P.'s | 24 |
| Downing Street address | 22 |
| Downing Street dessert | 22 |
| Downing Street distance | 23 |
| Downing, Elm, Main et al. | 25 |
| Download for an iPhone | 22 |
| Downloadable cell phone alert | 29 |
| Downloadable illustrations | 26 |
| Downloadable media player | 25 |
| Downloaded-music holder | 23 |
| Downloader's directive | 26 |
| Downloads for mobile devices | 28 |
| Downright, so to speak | 22 |
| Downs of "20/20" | 26 |
| Downs or salts preceder | 23 |
| Downs ______ (Toronto suburb) | 29 |
| Downsides of childbirth | 23 |
| Downsize without layoffs | 24 |
| Downsizing, so to speak | 23 |
| Downstairs group on TV | 22 |
| Downton Abbey employee | 22 |
| Downtown area in many cities | 28 |
| Downtown area of Manhattan | 26 |
| Downtown area, informally | 25 |
| Downtown Honolulu landmark | 26 |
| Downtown Julie Brown and such | 29 |
| Downtown L.A. attraction | 24 |
| Downtown landing spots | 22 |
| Downtown New York area | 22 |
| Downward dog discipline | 23 |
| Downward Facing Dog sounds? | 27 |
| Downward flight maneuver | 24 |
| Downward-facing dog practice | 28 |
| Downwind side of the river | 26 |
| Downyflake alternative | 22 |
| Dowsing rods, essentially | 25 |
| Doyen in "Dallas" | 27 |
| Doyle Brunson announcement | 26 |
| Doyle of namesake grunge band | 29 |
| Doyle's famous ruse | 23 |
| Doyle's middle name | 23 |
| Doyle's was red-headed | 26 |
| Doz. between 1100 and 2300 | 26 |
| Doze, with "out" | 26 |
| Dozed, with "off" | 27 |
| Dozen for one's dearest | 27 |
| Dozens are sold every day | 25 |
| Dozes, with "off" | 27 |
| Dr Pepper alternatives | 22 |
| Dr Pepper and Dr. Brown's | 29 |
| Dr Pepper Museum locale | 23 |
| Dr Pepper or Mountain Dew | 25 |
| Dr Pepper Snapple Group brand | 29 |
| Dr. Ben of '60s TV | 22 |
| Dr. Brown's ___-Ray soda | 28 |
| Dr. Bunsen Honeydew, e.g. | 25 |
| Dr. certified by the RIAA | 25 |
| Dr. Chandra's creation | 26 |
| Dr. concerned with rhythm | 25 |