| Twelve-note scale used by Schoenberg | 36 |
| Twelve-step program for children of drinkers | 44 |
| Twelve-step program for friends and relatives | 45 |
| Twelve-time presidential candidate | 34 |
| Twelve-time Pro Bowl player Junior | 34 |
| Twentieth-century piano great Van ___ | 37 |
| Twenty : English :: ___ : Italian | 33 |
| Twenty-first Amendment opponents | 32 |
| Twenty-first word of the Pledge of Allegiance | 45 |
| Twenty-second letter of the Greek alphabet | 42 |
| Twenty-third letter of the Hebrew alphabet | 42 |
| Twenty-year sleeper or embarrassing sound | 41 |
| Twerking and Candy Crush Saga, for two | 38 |
| Twice or more (with "once") | 37 |
| Twice spun-off TV show set in Vegas | 35 |
| Twice, "Notorious" band | 33 |
| Twice, a guitar effect used by Hendrix | 38 |
| Twice, a noted Chinese dissident/artist | 39 |
| Twice, a Robin Williams sitcom catchphrase | 42 |
| Twice, Robert Kennedy's assassin | 36 |
| Twice-beaten Joe Louis challenger | 33 |
| Twice-overthrown leader of Haiti | 32 |
| Twiggy's look in '60s fashion | 37 |
| Twilight Singers "Too Tough ___" | 42 |
| Twilled fabric of European region | 33 |
| Twin associated with boho-chic fashion | 38 |
| Twin Cities airport, on luggage tags | 36 |
| Twin giants slain by Apollo and Artemis | 39 |
| Twin in ''The Comedy of Errors'' | 48 |
| Twin killings, in baseball: Abbr. | 33 |
| Twin killings, on a diamond: Abbr. | 34 |
| Twin Ronnie or Reggie of London crime | 37 |
| Twin Tony whose #6 jersey was retired | 37 |
| Twin vampire in "The Twilight Saga" | 45 |
| Twin who adopted the surname Bunker | 35 |
| Twin who was quite attached to his brother | 42 |
| Twin with a heart for his brother? | 34 |
| Twinings-themed crib decoration? | 32 |
| Twins player in "Big Business" | 40 |
| Twins player in "House of Numbers" | 44 |
| Twins' name at the 1984 Olympics | 36 |
| Twist contest winner of a 1994 film | 35 |
| Twist ending author after turning to symbolism? | 47 |
| Twist in "Oliver Twist" | 33 |
| Twist pioneer many years after Chubby? | 38 |
| Twisted character in “Oliver Twist” | 43 |
| Twisted forcibly (with "out") | 39 |
| Twisted person or Moore documentary | 35 |
| Twisted Sister "Under the ___" | 40 |
| Twisted Sister "___ Take It" | 38 |
| Twists and turns in a bowling alley | 35 |
| Twists of paper for lighting candles | 36 |
| Twisty hair style for active people? | 36 |
| Twitter's was 11/7/2013: Abbr. | 34 |
| Twitter's was on November 7th, 2013 | 39 |
| Two ''G'' nations | 33 |
| Two "King Lear" characters | 36 |
| Two "Monday, Monday" singers | 38 |
| Two ... two ... two mints in one | 32 |
| Two actors make an "Albert" sandwich | 46 |
| Two adjectives applied to roads? | 32 |
| Two bells on the afternoon watch | 32 |
| Two bells, in a sailor's middle watch | 41 |
| Two bottled liquids kept in a cabinet? | 38 |
| Two bucks, on Mediterranean Avenue | 34 |
| Two cents' worth, so to speak | 33 |
| Two characters in "Lincoln"? | 38 |
| Two cloned basketball centers play spectacularly? | 49 |
| Two concerns of a secretive voodoo practicer? | 45 |
| Two cowboy portrayers and an actor | 34 |
| Two cows in love but not married? | 33 |
| Two cups that don't make a pint | 35 |
| Two days before St. Patrick's Day, e.g. | 43 |
| Two decades after Cleopatra's death | 39 |
| Two districts noted for restaurants | 35 |
| Two eighth notes, for iTunes, e.g. | 34 |
| Two features of a hurried golf game? | 36 |
| Two features of interest on the sunken Titanic? | 47 |
| Two fifths of a dead man's hand | 35 |
| Two filming sessions for a skydiving scene? | 43 |
| Two football greats and an author | 33 |
| Two former Yankee southpaws and a director | 42 |
| Two forms of ID for a couch potato? | 35 |
| Two forms of ID for an outback musician? | 40 |
| Two forms of ID for Britney Spears? | 35 |
| Two forms of ID for geometry students? | 38 |
| Two forms of ID for inseparable friends? | 40 |
| Two forms of ID for Mother Goose? | 33 |
| Two forms of ID for somber speakers? | 36 |
| Two forms of ID for the wedding party? | 38 |
| Two great N.Y. centers of culture | 33 |
| Two horizontal lines, on a BB scorecard | 39 |
| Two in the middle of "middle" | 39 |
| Two key points on an ellipse's major axis | 45 |
| Two make "boxcars" at Vegas | 37 |
| Two merged barbershop groups, say | 33 |
| Two Mexican provisional presidents | 34 |
| Two more birds named for their calls | 36 |
| Two networks showing the same game? | 35 |
| Two no-hit pitchers: 1969–68 | 35 |