| First Secretary of Transportation | 33 |
| First section of a textbook, for short | 38 |
| First sergeant, in military slang | 33 |
| First Sherlock Holmes book: 1887 | 32 |
| First showing at an all-day film festival? (1988) | 49 |
| First sign of a highway headache | 32 |
| First single released on Apple Records | 38 |
| First sitting president to visit the West Coast | 47 |
| First son of a President to become President | 44 |
| First Song of the Year Grammy winner | 36 |
| First song on "More of the Monkees" | 45 |
| First sovereign of Great Britain | 32 |
| First spacecraft to orbit Jupiter | 33 |
| First spacecraft to reach Uranus and Neptune | 44 |
| First Spanish actor to win an Oscar | 35 |
| First speaker in "Macbeth" | 36 |
| First spin-off from "All in the Family" | 49 |
| First sports commentator to receive an Emmy | 43 |
| First sports movie to win Best Picture | 38 |
| First square of some board games | 32 |
| First star ever photographed, 1850 | 34 |
| First state governor of Virginia | 32 |
| First steamship to cross the Atlantic | 37 |
| First Steely Dan album to win a Grammy | 38 |
| First step in addicts' treatment | 36 |
| First substitute on a basketball bench | 38 |
| First successful American automaker | 35 |
| First Super Bowl won by an African American coach | 49 |
| First Super Bowl won by the Giants | 34 |
| First talking pet in American comics | 36 |
| First tea sold in individual packets | 36 |
| First team to play in a domed stadium | 37 |
| First team to win five Super Bowls | 34 |
| First territorial capital of Alaska | 35 |
| First The Wall Street Journal editor | 36 |
| First these, then you get "to riches" | 47 |
| First thing an Indiana cheerleader calls for | 44 |
| First thing Emory cheerleaders call for | 39 |
| First thing in the water, usually | 33 |
| First thing Iowa State cheerleaders ask for? | 44 |
| First thing plucked in "Alouette" | 43 |
| First thing usually hit by a bowling ball | 41 |
| First thing you do on December 25th | 35 |
| First things half of all newlyweds change? | 42 |
| First third of a classic canine star's name | 47 |
| First three community cards in hold'em | 42 |
| First three numbers, in some directories | 40 |
| First three-letter White House monogram | 39 |
| First three-time heavyweight champ | 34 |
| First tight end in the Football Hall of Fame | 44 |
| First to attack in "The Birds" | 40 |
| First to broadcast hockey play-by-play | 38 |
| First to draw Santa as he looks today | 37 |
| First to draw the Democrats' mule | 37 |
| First to leave the table, perhaps | 33 |
| First to recognize the returning Odysseus | 41 |
| First to round the Cape of Good Hope | 36 |
| First to show that men are pigs? | 32 |
| First to span the Atlantic wirelessly | 37 |
| First to wake, according to Ovid | 32 |
| First to win 100 NCAA team championships | 40 |
| First toothbrush to go to the moon | 34 |
| First top 10 hit for Hall and Oates | 35 |
| First Top 40 hit for "Weird Al" | 41 |
| First Top 40 hit for Weird Al Yankovic | 38 |
| First track on a mix tape, usually | 34 |
| First track on many a Broadway album | 36 |
| First track on the 1956 album "Calypso" | 49 |
| First tribe encountered by Lewis and Clark | 42 |
| First tribe met by Lewis and Clark | 34 |
| First TV series to show a baby being born, 1955 | 47 |
| First two notes of a descending scale | 37 |
| First two of "three little words" | 43 |
| First two reindeer named in Rudolph's song | 46 |
| First two words of "Dixie," often | 43 |
| First two words of "Green Eggs and Ham" | 49 |
| First two words of "Waltzing Matilda" | 47 |
| First two words of a 1964 Impressions hit | 41 |
| First U.S. astronaut to circle the earth | 40 |
| First U.S. college to award degrees to women | 44 |
| First U.S. college to give degrees to women | 43 |
| First U.S. journalist to interview Gorbachev | 44 |
| First U.S. Olympic Hall of Fame gymnast | 39 |
| First U.S. paper to run KenKen puzzles | 38 |
| First U.S. pres. to travel in a submarine | 41 |
| First U.S. screen portrayer of Dr. Fu Manchu | 44 |
| First U.S. state to abolish slavery | 35 |
| First U.S. vice president not to become president | 49 |
| First U.S. woman governor __ Tayloe Ross | 40 |
| First United States vice president | 34 |
| First US university to award a Ph.D. | 36 |
| First variable star to be discovered | 36 |
| First vehicle in a funeral procession | 37 |
| First video broadcast on MTV2 (8/1/96) | 38 |
| First volume of an encyclopedia, perhaps | 40 |
| First Western televised in color | 32 |
| First winner of a Best Animated Feature Oscar | 45 |
| First winner of consecutive Oscars | 34 |
| First woman director of the U.S. Mint | 37 |
| First woman director of U.S. Mint | 33 |