| First or second number in the Fibonacci sequence | 48 |
| First or second word of Karen O's band name | 47 |
| First or third "T" in "TW3" | 47 |
| First or third quarter phenomenon | 33 |
| First orange property on a Monopoly board | 41 |
| First order of Greek architecture | 33 |
| First Oscar winner for Animated Feature | 39 |
| First Oscar winner for animated films | 37 |
| First overall pick in the 2004 NFL draft | 40 |
| First overall pick of the 2007 NHL draft | 40 |
| First part of "The Divine Comedy" | 43 |
| First part of a Caesarean declaration | 37 |
| First part of a form to fill out | 32 |
| First part of a Groucho Marx comment | 36 |
| First part of a Harvey Pekar quote | 34 |
| First part of a hit for this crossword | 38 |
| First part of a Latin conjugation | 33 |
| First part of a quote by Aristotle | 34 |
| First part of an entertaining thought | 37 |
| First part of diner's complaint | 35 |
| First part of psychosexual development | 38 |
| First part of the waiter's reply | 36 |
| First person to reach the North and South Poles | 47 |
| First person to travel faster than sound | 40 |
| First person with two Nobel Prizes | 34 |
| First person you see at some fine restaurants | 45 |
| First PGA player to shoot his age, with a 67 | 44 |
| First philosopher to mention Atlantis | 37 |
| First pianist to use a jazz organ | 33 |
| First piece of evidence presented at trial | 42 |
| First pitcher to record 5,000 career strikeouts | 47 |
| First planet discovered using a telescope | 41 |
| First player elected to the Baseball Hall of Fame | 49 |
| First player listed in "Total Baseball" | 49 |
| First player to win tennis's Grand Slam | 43 |
| First poet to read at a presidential inauguration | 49 |
| First poet to use the terza rima verse form | 43 |
| First pope called "the Great" | 39 |
| First pope in a baker's dozen | 33 |
| First pope to be called "the Great" | 45 |
| First pope with the title "the Great" | 47 |
| First popular song that won an Emmy | 35 |
| First possible inning for a walk-off homer | 42 |
| First Pres. born west of the Mississippi | 40 |
| First pres. to visit China while in office | 42 |
| First president born in the 19th century | 40 |
| First president born outside the continental U.S. | 49 |
| First president not born in the continental U.S. | 48 |
| First president of Czechoslovakia | 33 |
| First president of League of Women Voters | 41 |
| First president of the 20th century | 35 |
| First president of the Czech Republic | 37 |
| First president of the German republic, 1919 | 44 |
| First president of the Sierra Club | 34 |
| First president of the Transvaal | 32 |
| First president to file an income tax return | 44 |
| First president to get married while in office | 46 |
| First president to have a veto overridden | 41 |
| First president to live in the White House | 42 |
| First president to marry while in office | 40 |
| First president to occupy the Oval Office | 41 |
| First president to occupy the White House | 41 |
| First president to take office by succession | 44 |
| First president to throw an Opening Day pitch | 45 |
| First president who was the son of a president | 46 |
| First president who wasn't elected | 38 |
| First president with a Twitter account | 38 |
| First prime minister of free India | 34 |
| First prime minister of Great Britain | 37 |
| First prime minister of India or jacket style | 45 |
| First prime minister of the U.S.S.R. | 36 |
| First priority of an Australian beverage company? | 49 |
| First private engineering school in the U.S. | 44 |
| First prize at the 1992 Olympics | 32 |
| First pro team to play on artificial turf | 41 |
| First pronoun in "America" | 36 |
| First pronoun in "Little Miss Muffet" | 47 |
| First published black woman poet in America | 43 |
| First publisher of the game Mouse Trap | 38 |
| First Pulitzer Prize novelist: 1918 | 35 |
| First punch of an old Roman bout? | 33 |
| First question at a start-up company? | 37 |
| First rapper to win a Best Song Oscar | 37 |
| First razor with a pivoting head | 32 |
| First Reality Primetime Emmy winner | 35 |
| First refugee named Canadian Prime Minister | 43 |
| First Republic of Texas president | 33 |
| First resident of the White House | 33 |
| First responders' destinations, briefly | 43 |
| First right-handed batter to reach 500 home runs | 48 |
| First rock star to appear on a U.S. stamp | 41 |
| First round exemptions, in tournaments | 38 |
| First Russian Literature Nobelist | 33 |
| First Russian Literature Nobelist Ivan | 38 |
| First Russian to be called "czar" | 43 |
| First Scorsese/DeNiro collaboration | 35 |
| First Sec. of Transportation: 1966 | 34 |
| First Secretary General of the U.N. | 35 |
| First secretary of H.E.W., 1953, ___ Culp Hobby | 47 |
| First secretary of Homeland Security | 36 |