| First American orbiter | 22 |
| First American movie to show a toilet flushing | 46 |
| First American minister to England | 34 |
| First American magazine to excerpt "Moby-Dick" | 56 |
| First American literature Nobelist | 34 |
| First American independent movie to get a Best Original Screenplay nomination | 77 |
| First American in space | 23 |
| First American in orbit | 23 |
| First American female astronaut | 31 |
| First American executed for spying | 34 |
| First American diplomat abroad | 30 |
| First American canal | 20 |
| First American baseball stadium with a retractable roof | 55 |
| First American auto company | 27 |
| First Amendment word | 20 |
| First Amendment subj. | 21 |
| First Amendment right | 21 |
| First amendment org. | 20 |
| First Amendment lobbyists, for short | 36 |
| First Amendment lobbying gp. | 28 |
| First Amendment lobby | 21 |
| First Amendment guarantee | 25 |
| First Amendment freedom | 23 |
| First Amendment defender, for short | 35 |
| First Amendment concern | 23 |
| First Amendment advocacy grp. | 29 |
| First Amendment advocacy gp. | 28 |
| First Amdt. lobby | 17 |
| First Amdt. defender | 20 |
| First all-purpose digital computer | 34 |
| First alert, often | 18 |
| First albums? | 13 |
| First album track, perhaps | 26 |
| First album in a Green Day trilogy | 34 |
| First Alaskan governor | 22 |
| First airline with commercial transpacific passenger flights | 60 |
| First airline with a transpolar route | 37 |
| First airline to operate a transpolar route | 43 |
| First airing | 12 |
| First aide, for short? | 22 |
| First aid technique (abbr.) | 27 |
| First aid staple | 16 |
| First aid provider, for short | 29 |
| First aid provider, briefly | 27 |
| First aid plant | 15 |
| First aid or mess | 17 |
| First aid ointment | 18 |
| First aid kit staple | 20 |
| First aid kit item | 18 |
| First aid item | 14 |
| First aid for sprains | 21 |
| First aid for a sprain | 22 |
| First aid equipment | 19 |
| First aid case | 14 |
| First aid boxes | 15 |
| First aid box | 13 |
| First aid balm | 14 |
| First aid administrant on a battlefield | 39 |
| First age in geologic history | 29 |
| First African-born Literature Nobelist | 38 |
| First African-American US Open champ | 36 |
| First African-American to win a Gold Glove in both leagues | 58 |
| First African-American to play at the Masters | 45 |
| First African-American selected for a U.S. Davis Cup team | 57 |
| First African-American secretary of state | 41 |
| First African-American Republican National Committee chairman | 61 |
| First African-American on a US stamp | 36 |
| First African-American major-league coach Buck | 46 |
| First African-American major-league coach | 41 |
| First African-American major-league catcher | 43 |
| First African-American golfer with 12 P.G.A. Tour wins | 54 |
| First African-American golfer to play in the Masters | 52 |
| First AFL team to beat an NFL team | 34 |
| First AFL president, Samuel | 27 |
| First actress to win an Oscar in a foreign-language film | 56 |
| First actress to play Yente in Broadway's "Fiddler on the Roof" | 77 |
| First actor to turn down an Academy Award | 41 |
| First actor to play Loman | 25 |
| First action sequence of "Saving Private Ryan" | 56 |
| First action figure | 19 |
| First act of the ballet "Jewels," by George | 53 |
| First act in a revue | 20 |
| First act | 9 |
| First acrylic fiber | 19 |
| First Across word in the world's first crossword | 52 |
| First abode | 11 |
| First A.F.L.-C.I.O. president | 29 |
| First A-bomb test | 17 |
| First 45 maker, briefly | 23 |
| First 3 of 26 | 13 |
| First 10 amendments | 19 |
| First 007 flick (abbr.) | 23 |
| First 007 flick | 15 |
| First 007 film | 14 |
| First ... | 9 |
| First (Abbr.) | 13 |
| First "Today" host Dave | 33 |
| First "Sunday Morning" host | 37 |
| First "O" of O-O-O | 28 |
| First "Mission: Impossible" TV production company | 59 |