| First double, and first female, Nobelist | 40 |
| First donor? | 12 |
| First Dominican-born Major League Baseball manager | 50 |
| First Dominican manager in the major leagues | 44 |
| First Dominican manager in MLB history | 38 |
| First Dominican major-league manager | 36 |
| First domed ballpark | 20 |
| First dog walker, maybe | 23 |
| First dog to orbit Earth | 24 |
| First Dog of the 1940s | 22 |
| First dog in space | 18 |
| First Dodge with front-wheel drive | 34 |
| First divorced U.S. president | 29 |
| First division of an act | 24 |
| First distiller to sell whiskey by the bottle | 45 |
| First discovered asteroid | 25 |
| First director of the U.S. Peace Corps | 38 |
| First dinner course | 19 |
| First dime novel: Var. | 22 |
| First digs? | 11 |
| First digital computer | 22 |
| First digit of current year | 27 |
| First digit in an Alaskan zip code | 34 |
| First digit in a Hawaiian zip code | 34 |
| First digit in a California zip code | 36 |
| First digit a toddler is taught, often | 38 |
| First designated spot at a swim meet, perhaps | 45 |
| First degs. | 11 |
| First degrees (abbr.) | 21 |
| First degrees | 13 |
| First defenseman to lead N.H.L. in scoring | 42 |
| First deadly sin | 16 |
| First day of the rest of your life | 34 |
| First day of the month, in ancient Rome | 39 |
| First day of summer or winter | 29 |
| First day of spring, to Vietnamese | 34 |
| First day of most PGA tourneys | 30 |
| First day of Lent: ___ Wednesday | 32 |
| First day of a fall mo.? | 24 |
| First daughter, once | 20 |
| First Daughter twins | 20 |
| First Daughter of the late 1970s | 32 |
| First daughter of the '90s | 30 |
| First Daughter of the '60s | 30 |
| First daughter of 1977-81 | 25 |
| First daughter in the Carter White House | 40 |
| First daughter in the '90s | 30 |
| First daughter Carter | 21 |
| First Daughter | 14 |
| First date doings | 17 |
| First dark horse elected U.S. President | 39 |
| First Czech Republic president | 30 |
| First czar of Russia | 20 |
| First czar | 10 |
| First cut on the album "Sticky Fingers" | 49 |
| First customer for the Boeing 787 | 33 |
| First critters on a farm? | 25 |
| First creature off the ark | 26 |
| First created being, in myth | 28 |
| First created | 13 |
| First couture house to make a designer sports car | 49 |
| First cousins' dads | 23 |
| First cousin's mom | 22 |
| First cousin of Princes William and Harry | 41 |
| First cousin of Prince William | 30 |
| First courses | 13 |
| First course? | 13 |
| First course, sometimes | 23 |
| First course, perhaps | 21 |
| First course, often | 19 |
| First course, maybe | 19 |
| First course, generally | 23 |
| First course selection | 22 |
| First course option on a North African menu? | 44 |
| First course option | 19 |
| First course of action | 22 |
| First course dish in a trattoria, at times | 42 |
| First course at the prison? | 27 |
| First course at a German restaurant, maybe | 42 |
| First course | 12 |
| First couple's place | 24 |
| First couple's home | 23 |
| First country you'd come to if you sail west from Mumbai | 60 |
| First country singer to win the Best New Artist Grammy | 54 |
| First Council of Nicaea formulation | 35 |
| First correct "Hollywood Squares" square | 50 |
| First correct "Hollywood Squares" spot | 48 |
| First corner after "Go" in Monopoly | 45 |
| First Constitution section | 26 |
| First conspirator to stab Caesar | 32 |
| First Congolese P.M. Lumumba | 28 |
| First computer-animated film to receive a PG rating | 51 |
| First computer to predict a U.S. election outcome | 49 |
| First computer language used for embedded systems | 49 |
| First computer company with a Super Bowl commercial | 51 |
| First computer | 14 |
| First compass point, alphabetically | 35 |
| First company to successfully manufacture bubblegum | 51 |
| First company to stream an entire album on the Internet | 55 |
| First company to sell soft contact lenses | 41 |