| First initial + last name, often | 32 |
| First industrial revolution? | 28 |
| First inductee into the Baseball Hall of Fame | 45 |
| First indicator of a good song? | 31 |
| First Indian tribe to sign a treaty with the U.S. government | 60 |
| First Indian tribe met by Lewis and Clark | 41 |
| First Indian ruler to embrace Buddhism | 38 |
| First Indian prime minister | 27 |
| First Indian P.M. | 17 |
| First Indian American to be governor of an American state | 57 |
| First in time: Prefix | 21 |
| First in time | 13 |
| First in the waiting line | 25 |
| First in the rankings | 21 |
| First in the race? | 18 |
| First in the race | 17 |
| First in the Hebrew alphabet | 28 |
| First in the film credits | 25 |
| First in order | 14 |
| First in NYC, e.g. | 18 |
| First in line? | 14 |
| First in line, say | 18 |
| First in line, perhaps | 22 |
| First in line to the throne | 27 |
| First in line for the throne, maybe | 35 |
| First in line | 13 |
| First in John Wayne's "Cavalry Trilogy" | 53 |
| First in double figures | 23 |
| First in courage | 16 |
| First in an order | 17 |
| First in age | 12 |
| First in a trio | 15 |
| First in a string of popes | 26 |
| First in a string of 13 popes | 29 |
| First in a series of Web postings | 33 |
| First in a series of slasher flicks | 35 |
| First in a series of 26 | 23 |
| First in a series | 17 |
| First in a popular horror movie franchise | 41 |
| First in a pair | 15 |
| First in a multi-volume set | 27 |
| First in a long line? | 21 |
| First in a long line of sitcoms? | 32 |
| First in a line of Russian grand princes | 40 |
| First in a line of cars | 23 |
| First in a line of 260+ | 23 |
| First in a John Updike novel series | 35 |
| First in a horror film franchise | 32 |
| First in a historical trio | 26 |
| First in a classical sequence | 29 |
| First in a car, say | 19 |
| First in a (non-contiguous) series of thirteen popes | 52 |
| First impeached U.S. president | 30 |
| First husband? | 14 |
| First husband of Bathsheba | 26 |
| First husband | 13 |
| First human to orbit the Earth | 30 |
| First human to die | 18 |
| First human in space | 20 |
| First human born, according to the Bible | 40 |
| First houseboat | 15 |
| First host of "The Family Feud" | 41 |
| First host of "Jeopardy!" | 35 |
| First host of "America's Got Talent" | 50 |
| First host of "America's Funniest Home Videos" | 60 |
| First host of ''How to Boil Water'' | 51 |
| First horse to win the Triple Crown | 35 |
| First horse to compete in all three Triple Crown races | 54 |
| First Honorary Reagan Fellow of Eureka College | 46 |
| First homicide victim | 21 |
| First home? | 11 |
| First home of the University of Nevada | 38 |
| First home | 10 |
| First Holy Roman emperor | 24 |
| First hole in the head? | 23 |
| First holder of the title Supreme Governor of the Church of England | 67 |
| First hockey player to win Sports Illustrated's Sportsman of the Year | 73 |
| First hit for Zhané | 22 |
| First hit for the Police | 24 |
| First hit for The Moody Blues | 29 |
| First hit for The 4 Seasons | 27 |
| First hit for Otis Redding | 26 |
| First hit by the Police, 1979 | 29 |
| First hit by Rodgers-Hart | 25 |
| First hip-hop single to reach #1 on the Billboard charts | 56 |
| First high priest of the Hebrews | 32 |
| First Hebrew patriarch (Var.) | 29 |
| First Hebrew patriarch | 22 |
| First Hebrew month | 18 |
| First Hebrew letter: Var. | 25 |
| First Hebrew letter, in some transliterations | 45 |
| First Hebrew letter (var.) | 26 |
| First Hebrew letter | 19 |
| First Hebrew calendar month | 27 |
| First heavyweight champ | 23 |
| First hard rock band to score a #1 country hit | 46 |
| First Hannibal Lecter novel | 27 |
| First half of things we all memorized | 37 |
| First half of the files? | 24 |
| First half of the alphabet | 26 |