| First lady of the United States (1861-1865) | 43 |
| First Lady of the 40's | 26 |
| First lady of the 1980s | 23 |
| First lady of the 1950s | 23 |
| First Lady of the 1940s | 23 |
| First lady of the 1910s | 23 |
| First Lady of Song Fitzgerald | 29 |
| First lady of song | 18 |
| First lady of scat, familiarly | 30 |
| First lady of scat | 18 |
| First Lady of Olympus | 21 |
| First Lady of Mount Olympus | 27 |
| First lady of Leeds | 19 |
| First lady of Jewish folklore | 29 |
| First Lady of Jazz | 18 |
| First Lady of California | 24 |
| First Lady of 1900 | 18 |
| First lady McKinley | 19 |
| First Lady Madison | 18 |
| First Lady Lou Hoover, ___ Henry | 32 |
| First lady in Parliament | 24 |
| First Lady in 1929 | 18 |
| First lady in 1900 | 18 |
| First lady Harrison | 19 |
| First Lady Grace's man | 26 |
| First lady Gorbacheva | 21 |
| First lady from 1946 to 1952 | 28 |
| First Lady Ford | 15 |
| First Lady for 13 years | 23 |
| First lady Eisenhower | 21 |
| First lady dubbed "Spiritual Leader of the Nation" | 60 |
| First Lady Claudia ___ Johnson | 30 |
| First lady Bush | 15 |
| First lady between Lou and Bess | 31 |
| First lady between Frances and Edith | 36 |
| First lady between Eleanor and Mamie | 36 |
| First lady between Bess and Jackie | 34 |
| First lady before Michelle | 26 |
| First lady before Mamie | 23 |
| First lady before Jackie | 24 |
| First lady before Eleanor | 25 |
| First lady before Abigail | 25 |
| First lady and diplomat Roosevelt | 33 |
| First lady after Lou | 20 |
| First Lady after Lady Bird | 26 |
| First lady after Hillary | 24 |
| First lady after Eleanor | 24 |
| First lady after Bess | 21 |
| First lady | 10 |
| First Labor P.M. to win consecutive terms | 41 |
| First Korean president | 22 |
| First knuckleballer to win the Cy Young | 39 |
| First known variable star | 25 |
| First known European to reach New Zealand | 41 |
| First known asteroid | 20 |
| First king of the Franks | 24 |
| First king of the English | 25 |
| First king of the Anglo-Saxons | 30 |
| First king of Phliasia, in myth | 31 |
| First king of modern Greece | 27 |
| First king of Jordan | 20 |
| First king of Israel | 20 |
| First king of Iraq: 1921–33 | 34 |
| First king of England | 21 |
| First king of Egypt | 19 |
| First king buried in Westminster Abbey | 38 |
| First killer | 12 |
| First khan | 10 |
| First Kentucky Derby winner: 1875 | 33 |
| First justice alphabetically in the history of the Supreme Court | 64 |
| First jobs for some | 19 |
| First job, for many teenagers | 29 |
| First job, for many | 19 |
| First job when editing a book? | 30 |
| First job title, for many teenagers | 35 |
| First Jewish superstar in the major leagues | 43 |
| First jazz musician to win a Pulitzer Prize | 43 |
| First Japanese-Canadian MP | 26 |
| First Japanese-American congressman Daniel | 42 |
| First Japanese prime minister born after WWII | 45 |
| First Japanese infielder to sign with a major-league team, familiarly | 69 |
| First Japanese golfer to win a PGA Tour event | 45 |
| First Japanese car to be produced in the U.S. | 45 |
| First James Bond movie | 22 |
| First James Bond flick | 22 |
| First James Bond film | 21 |
| First item on a certain table | 29 |
| First Italian course? | 21 |
| First Israeli ambassador to the UN | 34 |
| First Israeli ambassador to the U.N. | 36 |
| First Irishman to win a Nobel Prize | 35 |
| First Irish P.M. | 16 |
| First invitees | 14 |
| First International Gymnastics Hall of Fame inductee | 52 |
| First insurer to advertise on television | 40 |
| First instruction, often | 24 |
| First instruction in many a homework assignment | 47 |
| First instruction | 17 |
| First installment of a miniseries | 33 |
| First installment | 17 |