| First Nobelist in Physics | 25 |
| First NLCS winners | 18 |
| First NL player to hit 500 Home Runs | 36 |
| First nine in a series | 22 |
| First Niagara Center player | 27 |
| First Niagara Center NHLer | 26 |
| First NHL player to win the Art Ross Trophy, Maurice Richard Trophy, Lester B. Pearson Award, and Hart Memorial Trophy in a single season | 137 |
| First NHL defenseman to score 40 goals in a season | 50 |
| First NHL 2000 point scorer | 27 |
| First NFL team with helmet logos | 32 |
| First NFL quarterback to pass for 5,000 yards in one season | 59 |
| First NFL Man of the Year Award recipient (1970) | 48 |
| First newspapers on the street | 30 |
| First newspaper to send war correspondents, with "The" | 64 |
| First New Yorker cover artist ___ Irvin | 39 |
| First New World printer | 23 |
| First New Testament book | 24 |
| First network to stream full-length episodes | 44 |
| First network to show "The Wizard of Oz" | 50 |
| First Negro Leaguer inducted into the Baseball Hall of Fame | 59 |
| First near-Earth asteroid to be discovered | 42 |
| First NBA lottery pick of 1992 | 30 |
| First NBA Hall of Famer who went straight from high school to the pros | 70 |
| First Navy submarine, with "the" | 42 |
| First navigator to round the Cape of Good Hope | 46 |
| First native-born U.S. saint | 28 |
| First native-born leader of his country | 39 |
| First native-born American saint | 32 |
| First Nations tribe | 19 |
| First Nations members | 21 |
| First Nations group | 19 |
| First national park east of the Mississippi | 43 |
| First National of Wyoming? | 26 |
| First National Leaguer with eight consecutive 100-RBI seasons | 61 |
| First National Leaguer with eight consecutive 100-R.B.I. seasons | 64 |
| First National Leaguer with 500 home runs | 41 |
| First National Leaguer to hit 500 homers | 40 |
| First National Leaguer to hit 500 home runs | 43 |
| First National League player to reach 500 home runs | 51 |
| First National League player to pass 500 home runs | 50 |
| First National League player to hit 500 home runs | 49 |
| First National League member of the 500-homer club | 50 |
| First national brand of sugarless gum | 37 |
| First nation to win the World Cup: Abbr. | 40 |
| First nation to have an openly gay leader | 41 |
| First Nation | 12 |
| First nat. with a nuclear weapon | 32 |
| First names, in France | 22 |
| First names | 11 |
| First name? | 11 |
| First name with The News | 24 |
| First name that's feminine in English and masculine in Italian | 66 |
| First name that means "the king" | 42 |
| First name shared by both founders of Apple | 43 |
| First name revealed in the sixth season episode "The Switch" | 70 |
| First name on the Supreme Court | 31 |
| First name on the parallel bars | 31 |
| First name on the moon | 22 |
| First name on the Mayflower | 27 |
| First name on the Food Network | 30 |
| First name on the balance beam | 30 |
| First name on the album "Voice of the Xtabay" | 55 |
| First name on the 1954 album "Mambo!" | 47 |
| First name on the "Ugly Betty" set | 44 |
| First name on compacts | 22 |
| First name on Capitol Hill | 26 |
| First name on Broadway, 1951 | 28 |
| First name on an historic WWII bomber | 37 |
| First name on a WWII bomber | 27 |
| First name on a marquee | 23 |
| First name on a historic B-29 | 29 |
| First name on a bomber | 22 |
| First name on a 1945 bomber | 27 |
| First name on "Weekend Edition" | 41 |
| First name on "The View" | 34 |
| First name on "The Hills" | 35 |
| First name on "Saturday Night Live" | 45 |
| First name on "Rugrats" | 33 |
| First name on "Laugh-In" | 34 |
| First name on "Jeopardy!" | 35 |
| First name on "Good Times" | 36 |
| First name on "America's Next Top Model" | 54 |
| First name on "60 Minutes" | 36 |
| First name of Yippie fame | 25 |
| First name of Woodstock's last performer | 44 |
| First name of West Germany's first chancellor | 49 |
| First name of Vronsky's lover | 33 |
| First name of two U.S. presidents | 33 |
| First name of two Israeli prime ministers | 41 |
| First name of two first ladies | 30 |
| First name of TV's Monk | 27 |
| First name of Toland's subject | 34 |
| First name of today's honoree | 33 |
| First name of Time's 1995 Man of the Year | 45 |
| First name of Time's 1981 Man of the Year | 45 |
| First name of three wives of Henry VIII | 39 |
| First name of three U.S. presidents | 35 |
| First name of three presidents | 30 |
| First name of the wolf in Disney's "The Big Bad Wolf" | 67 |
| First name of The Veep | 22 |