| First of four giant syllables? | 30 |
| First of four giant syllables | 29 |
| First of four Chuck Noll championships | 38 |
| First of five Ws | 16 |
| First of five poker hands | 25 |
| First of five in "Hamlet" | 35 |
| First of fifty | 14 |
| First of England's Stuart kings | 35 |
| First of Caesar's claims | 28 |
| First of billions | 17 |
| First of August? | 16 |
| First of an old film septet | 27 |
| First of an ancient trio | 24 |
| First of all? | 13 |
| First of all of us | 18 |
| First of all | 12 |
| First of a vowel fivesome? | 26 |
| First of a trio from the Litany | 31 |
| First of a trio | 15 |
| First of a trilogy? | 19 |
| First of a trilogy | 18 |
| First of a traveling threesome | 30 |
| First of a succession of 13 | 27 |
| First of a string of 13 | 23 |
| First of a series | 17 |
| First of a Roman trio | 21 |
| First of a railway trio | 23 |
| First of a planned 26-book mystery series | 41 |
| First of a pair of lists | 24 |
| First of a pair of letters swapped six times in this puzzle's theme entries | 79 |
| First of a noted trio | 21 |
| First of a no-no septet | 23 |
| First of a musical trio | 23 |
| First of a much-quoted trio | 27 |
| First of a literary set | 23 |
| First of a Latin trio | 21 |
| First of a Latin threesome | 26 |
| First of a Latin I trio | 23 |
| First of a Kipling trio | 23 |
| First of a kind | 15 |
| First of a journalist's five W's | 40 |
| First of a Hope-Crosby film series | 34 |
| First of a Hebrew series | 24 |
| First of a hard-partying trio | 29 |
| First of a gender | 17 |
| First of a game trio | 20 |
| First of a famous trio | 22 |
| First of a famous sailing trio | 30 |
| First of a familiar trio | 24 |
| First of a doubleheader | 23 |
| First of a Disney trio | 22 |
| First of a dead-end trio? | 25 |
| First of a cautionary trio | 26 |
| First of 66 books: Abbr. | 24 |
| First of 50: Abbr. | 18 |
| First of 26 | 11 |
| First of 24 | 11 |
| First of 15 in a table game | 27 |
| First of 13 popes | 17 |
| First of 13 palindromes herein | 30 |
| First of 12: Abbr. | 18 |
| First of 12, in Madrid | 22 |
| First of 12 popes with a religious-sounding name | 48 |
| First of 12 popes (just put the Roman numeral in now and get the name from the crossings) | 89 |
| First of 12 popes | 17 |
| First of 12 in South America | 28 |
| First of 12 abroad | 18 |
| First of 12 | 11 |
| First of "The Chronicles of Clovis" | 45 |
| First odd prime | 15 |
| First octave above the treble clef | 34 |
| First occurrence, as of a symptom | 33 |
| First occupant of the White House | 33 |
| First observed asteroid | 23 |
| First Obi-Wan portrayer | 23 |
| First O, say | 12 |
| First O, maybe | 14 |
| First O of O-O-O | 16 |
| First O | 7 |
| First NYC subway | 16 |
| First Nunuvut Premier Okalik | 28 |
| First numero | 12 |
| First numbers | 13 |
| First number of three measurements | 34 |
| First number of a high-kicking show? | 36 |
| First number in season records | 30 |
| First number in a record | 24 |
| First number dialed when calling long distance | 46 |
| First number | 12 |
| First nudist colony | 19 |
| First nuclear-powered sub | 25 |
| First nuclear sub | 17 |
| First novel in Christopher Paolini's Inheritance Cycle | 58 |
| First novel in Cather's "prairie trilogy" | 55 |
| First note: Var. | 16 |
| First note of a tuba solo? | 26 |
| First note at the Moulin Rouge? | 31 |
| First non-European literature Nobelist (1913) | 45 |
| First non-elected U.S. president | 32 |
| First noble gas discovered | 26 |