| First or second, e.g.: Abbr. | 28 |
| First or second, e.g. | 21 |
| First or second word of Karen O's band name | 47 |
| First or second number in the Fibonacci sequence | 48 |
| First or second e.g. | 21 |
| First or reverse | 16 |
| First or neutral | 16 |
| First or last name in the Baseball Hall of Fame | 47 |
| First or last digit of D.C.'s area code | 43 |
| First or home, e.g. | 19 |
| First or home | 13 |
| First or going | 14 |
| First or foreign follower | 25 |
| First or fore follower | 22 |
| First or financial follower | 27 |
| First or final cut piece | 24 |
| First or economy | 16 |
| First option | 12 |
| First opera to premiere at London's Savoy Theatre, 1882 | 59 |
| First opera in which Pavarotti appeared | 39 |
| First opera composer | 20 |
| First opening? | 14 |
| First ones to spot the king's ghost, in "Hamlet" | 62 |
| First ones are special | 22 |
| First one-term U.S. president | 29 |
| First one-term president | 24 |
| First one to ___ (loser) | 24 |
| First one to stab Caesar | 24 |
| First one to fall | 17 |
| First one to be billed | 22 |
| First one out on the track | 26 |
| First one out in an auto race | 29 |
| First one out in "The Contest" | 40 |
| First one | 9 |
| First on the scene? | 19 |
| First on a calendario | 21 |
| First Olympics venue with women's hockey | 44 |
| First Olympics site | 19 |
| First Olympic venue for giant slalom | 36 |
| First Olympic Hall of Fame gymnast | 34 |
| First Olympic gymnast to receive a 10 | 37 |
| First Olympic Games site | 24 |
| First official act at Super Bowl | 32 |
| First offer? | 12 |
| First offender? | 15 |
| First off-shore driller, in 1947 | 32 |
| First of two sharp turns | 24 |
| First of two related lists | 26 |
| First of two pictures | 21 |
| First of two parts | 18 |
| First of two groups that may come in handy for this puzzle? | 59 |
| First of two choices | 20 |
| First of two before-and-after pictures | 38 |
| First of two baseball games | 27 |
| First of twelve signs | 21 |
| First of twelve popes | 21 |
| First of trillions | 18 |
| First of three? | 15 |
| First of three to be put out | 28 |
| First of three O's, perhaps | 31 |
| First of three Mets to hit a lead-off home run in a World Series Game 3 (he did it in '69, Garrett in '73, and Dykstra in '86) | 138 |
| First of three in a pencil/paper game | 37 |
| First of three consecutive rhyming letters | 42 |
| First of the year in Mexico City | 32 |
| First of the U.S.A. | 19 |
| First of the two sisters Jacob married | 38 |
| First of the toe trio | 21 |
| First of the Plantagenet kings | 30 |
| First of the Pevensie children to visit Narnia | 46 |
| First of the N.T. | 17 |
| First of the minor prophets | 27 |
| First of the Major Prophets | 27 |
| First of the major Hebrew prophets | 34 |
| First of the Maj. Prophets | 26 |
| First of the Latter Prophets | 28 |
| First of the James Bond films | 29 |
| First of the Greeks? | 20 |
| First of the five W's | 25 |
| First of the first pair | 23 |
| First of the eighth century | 27 |
| First of the Cavalier poets | 27 |
| First of the cardinals | 22 |
| First of the Biblical high priests | 34 |
| First of the Astaire-Rogers films: 1933 | 39 |
| First of spring? | 16 |
| First of six? | 13 |
| First of six popes | 18 |
| First of several? | 17 |
| First of seven? | 15 |
| First of seven (so far) | 23 |
| First of September? | 19 |
| First of Scrooge's visions | 30 |
| First of one gender | 19 |
| First of nine in "Strange Interlude" | 46 |
| First of multitudes | 19 |
| First of Mickey's wives | 27 |
| First of many body parts in "Alouette" | 48 |
| First of its kind? | 18 |
| First of HOMES | 14 |
| First of four Holy Roman emperors | 33 |