| First to leave the blocks | 25 |
| First to flood? | 15 |
| First to draw the Democrats' mule | 37 |
| First to draw Santa as he looks today | 37 |
| First to come? | 14 |
| First to come | 13 |
| First to broadcast hockey play-by-play | 38 |
| First to break the tape | 23 |
| First to be counted? | 20 |
| First to be counted | 19 |
| First to be chosen | 18 |
| First to be called up | 21 |
| First to be called | 18 |
| First to be admitted?: Abbr. | 28 |
| First to bat | 12 |
| First to attack in "The Birds" | 40 |
| First to arrive? | 16 |
| First to arrive, often: Abbr. | 29 |
| First to arrive | 15 |
| First time out | 14 |
| First tiller or killer | 22 |
| First tiller | 12 |
| First tight end in the Football Hall of Fame | 44 |
| First tight end elected to the Pro Football Hall of Fame | 56 |
| First three-time heavyweight champ | 34 |
| First three-letter White House monogram | 39 |
| First three of five | 19 |
| First three numbers, in some directories | 40 |
| First three kinds of holes | 26 |
| First three community cards in hold'em | 42 |
| First three colors of rainbow | 29 |
| First thought of | 16 |
| First third of an out | 21 |
| First third of a classic canine star's name | 47 |
| First things learned | 20 |
| First things half of all newlyweds change? | 42 |
| First things | 12 |
| First thing zoo employees learn at the reptile house? | 53 |
| First thing you do on December 25th | 35 |
| First thing usually hit by a bowling ball | 41 |
| First thing to do | 17 |
| First thing plucked in "Alouette" | 43 |
| First thing Iowa State cheerleaders ask for? | 44 |
| First thing in the water, usually | 33 |
| First thing Emory cheerleaders call for | 39 |
| First thing an Indiana cheerleader calls for | 44 |
| First these, then you get "to riches" | 47 |
| First The Wall Street Journal editor | 36 |
| First Thanksgiving locale | 25 |
| First Thanksgiving hosts | 24 |
| First Tevye | 11 |
| First territorial capital of Alaska | 35 |
| First term-limited pres. | 24 |
| First tennis player to win more than a million dollars in a single season | 73 |
| First tennis player to simultaneously hold Grand Slams on clay, grass and hardcourt | 83 |
| First temptation site | 21 |
| First telegrapher | 17 |
| First team to win five Super Bowls | 34 |
| First team to play in a domed stadium | 37 |
| First team | 10 |
| First tea sold in individual packets | 36 |
| First Tarzan portrayer | 22 |
| First talking pet in American comics | 36 |
| First T. Rex hit in 1970 | 24 |
| First synthetic dye | 19 |
| First symptoms, e.g. | 20 |
| First symptoms | 14 |
| First symbol on a musical staff | 31 |
| First symbol on a music line | 28 |
| First Syd Barrett solo album | 28 |
| First survey datum, often | 25 |
| First supersonic human | 22 |
| First Super Bowl won by the Giants | 34 |
| First Super Bowl won by the AFL | 31 |
| First Super Bowl won by an African American coach | 49 |
| First Super Bowl to be officially called "Super Bowl" | 63 |
| First Super Bowl that was actually called a Super Bowl | 54 |
| First Super Bowl rematch | 24 |
| First Super Bowl MVP | 20 |
| First Super Bowl M.V.P. | 23 |
| First Sum 41 hit | 16 |
| First suit? | 11 |
| First successful video game | 27 |
| First successful American automaker | 35 |
| First subway line in NYC | 24 |
| First subway line in N.Y.C. | 27 |
| First substitute on a basketball bench | 38 |
| First subject in Euclid's "Elements" | 50 |
| First subclause | 15 |
| First stroke setting | 20 |
| First stroke of a round | 23 |
| First stroke for many | 21 |
| First strip to win a Pulitzer | 29 |
| First stringers | 15 |
| First string? | 13 |
| First string | 12 |
| First strategy choice | 21 |
| First strategy | 14 |
| First stone thrower? | 20 |
| First stomach of a cow | 22 |