| Southernmost cross-country U.S. highway | 39 |
| Southernmost tip of South America | 33 |
| Southey's "The Curse of Kehama" | 45 |
| Southey's "___ of Kehama" | 39 |
| Southpaw pitcher Jim who won 16 Gold Gloves | 43 |
| Southpaw's haymakers, probably | 34 |
| Southwark, Vauxhall and Waterloo | 32 |
| Southwest Africa's ___ Desert | 33 |
| Southwest alternative, for short | 32 |
| Southwest Arizona's ___ Desert | 34 |
| Southwest chips-and-chili snacks | 32 |
| Southwest city founded by Mormon pioneers | 41 |
| Southwest desert that includes Death Valley | 43 |
| Southwest sch. whose mascot is King Triton | 42 |
| Southwestern city founded by Mormons | 36 |
| Southwestern gathering for folk dances | 38 |
| Southwestern geographical features | 34 |
| Southwestern livestock threatener | 33 |
| Southwestern shrubs yielding a cosmetic oil | 43 |
| Southwestern site of gypsum dunes | 33 |
| Souvenir at the NFL's big event? | 36 |
| Souvenir for the farmer's wife? | 35 |
| Souvenir from a tropical vacation? | 34 |
| Souvenir from the Petrified Forest? | 35 |
| Souvenir hunter who frequents smoky bars? | 41 |
| Souvenirs from the Worldwide Texas Tour? | 40 |
| Sovereign of the Mongol empire in India | 39 |
| Sovereign territory, synecdochically | 36 |
| Sovereign's 'I,' often | 34 |
| Soviet agency created from Rosta | 32 |
| Soviet anti-spy group in some James Bond novels | 47 |
| Soviet dissident-author Sharansky | 33 |
| Soviet economic program begun in '88 | 40 |
| Soviet leader who signed SALT I and II | 38 |
| Soviet Literature Nobelist Bunin | 32 |
| Soviet nuclear physicist Kurchatov | 34 |
| Soviet org. in James Bond stories | 33 |
| Soviet Physics Nobelist ___ Tamm | 32 |
| Soviet president: 1923–46 | 32 |
| Soviet spy Rudolf and actor Walter | 34 |
| Soviet spymaster in a John le Carré trilogy | 46 |
| Soviet W.W. II foreign affairs commissar | 40 |
| Soy, north of the Mexican border | 32 |
| Soybean appetizer served at sushi bars | 38 |
| Soyer's "Girl in a White ___" | 43 |
| Sp-[gasp]-speaks like th-[sniffle]-this | 39 |
| Sp. currency replaced by the euro | 33 |
| Spa employee, generally speaking | 32 |
| Spa in France's Haute-Savoie department | 43 |
| Spa offering that's not quite godlike? | 42 |
| Spa visitor who doesn't pay the bill? | 41 |
| Space bar neighbor, on some keyboards | 37 |
| Space between a bird's eye and bill | 39 |
| Space between a leaf and its supporting stem | 44 |
| Space between a leaf's veins | 32 |
| Space between dotted lines, maybe | 33 |
| Space between the eye and the bill | 34 |
| Space between the eye and the bill of a bird | 44 |
| Space cartoon set in the year 3000 | 34 |
| Space film (with "The") | 33 |
| Space flight's starting point | 33 |
| Space found in Who-Turned-Out-the-Lights-opoly? | 47 |
| Space laser program of the '80s | 35 |
| Space Mountain and Splash Mountain | 34 |
| Space needed to store a character of text | 41 |
| Space object with an event horizon | 34 |
| Space station assignment, for short | 35 |
| Space station for about 15 years | 32 |
| Space station launched by the Soviets | 37 |
| Space station that crashed to Earth in 2001 | 43 |
| Space station that fell to Earth in 2001 | 40 |
| Space station that had a supply of vodka | 40 |
| Space station that operated on Moscow time | 42 |
| Space station whose final module was Priroda | 44 |
| Space that ought to be in ZZ Topoly? | 36 |
| Space-saving abbr. hidden in four puzzle answers | 48 |
| Space-signal searcher's acronym | 35 |
| Spacecraft on a planet's surface | 36 |
| Spacecraft that began orbiting Saturn in 2004 | 45 |
| Spacehog "At Least I Got ___" | 39 |
| Spacehog debut "Resident ___" | 39 |
| Spacehog's debut "Resident ___" | 45 |
| Spacek of ''Crimes of the Heart'' | 49 |
| Spacek of "Coal Miner's Daughter" | 47 |
| Spacek of "Crimes of the Heart" | 41 |
| Spacek's "___ Man" | 32 |
| Spacely Space Sprockets employee | 32 |
| Spaces between lines, in printing | 33 |
| Spaces between objects or points | 32 |
| Spaces just under a bird's eyes | 35 |
| Spaceship that used the Moscow time zone | 40 |
| Spacewalks and moonwalks, briefly | 33 |
| Spacey of "American Beauty" | 37 |
| Spacey's "Superman Returns" role | 46 |
| Spacey/Bening Oscar-winning picture | 35 |
| Spade of "The Maltese Falcon" | 39 |
| Spades bid worth 100 points if successful | 41 |
| Spades in a four-spades bridge contract, say | 44 |
| Spaghetti makers' implements | 32 |
| Spaghetti sauce seasoning, sometimes | 36 |