| Mr. Flanders | 12 |
| Mr. Fixit, e.g. | 15 |
| Mr. Fixit's genre | 21 |
| Mr. Fixit who wrote over 100 symphonies? | 40 |
| Mr. Fixit | 9 |
| Mr. Fix-it, e.g. | 16 |
| Mr. Fix-It's job | 20 |
| Mr. Fix-It | 10 |
| Mr. Ferrari | 11 |
| Mr. Fawkes | 10 |
| Mr. Favre | 9 |
| Mr. Estrada | 11 |
| Mr. Escuela player | 18 |
| Mr. ELO | 7 |
| Mr. Ellington, in a 1977 song | 29 |
| Mr. Ellington | 13 |
| Mr. Ed's words of wisdom? | 29 |
| Mr. Ed's tidbit | 19 |
| Mr. Ed's reaction to a good joke? | 37 |
| Mr. Ed's mouthpiece | 23 |
| Mr. Ed's mom | 16 |
| Mr. Ed's fly swatter | 24 |
| Mr. Ed's abode | 18 |
| Mr. Ed with laryngitis | 22 |
| Mr. Ed has one | 14 |
| Mr. Ed being sarcastic? | 23 |
| Mr. Eban et al. | 15 |
| Mr. Eban | 8 |
| Mr. Eaton, familiarly | 21 |
| Mr. Eaton, familiarly | 22 |
| Mr. Durocher | 12 |
| Mr. Dullsville | 14 |
| Mr. Dracula | 11 |
| Mr. Doubleday | 13 |
| Mr. Dooley's creator | 24 |
| Mr. Domino | 10 |
| Mr. Dogg | 8 |
| Mr. Doe | 7 |
| Mr. Do-All | 10 |
| Mr. Dithers, to Dagwood | 23 |
| Mr. Dithers's wife | 22 |
| Mr. Dithers's fit | 21 |
| Mr. Dithers of the comics, for one | 34 |
| Mr. Disney | 10 |
| Mr. Diamond | 11 |
| Mr. Descartes | 13 |
| Mr. Deeds? | 10 |
| Mr. Deeds player | 16 |
| Mr. Deeds and Mrs. Doubtfire | 28 |
| Mr. de Coverley | 15 |
| Mr. Day | 7 |
| Mr. Davis | 9 |
| Mr. Darko | 9 |
| Mr. Darcy's creator | 23 |
| Mr. Danger while doing some lewd on-line chats? | 47 |
| Mr. Culbertson and others | 25 |
| Mr. Cub and others | 18 |
| Mr. Cross? | 10 |
| Mr. Crockett | 12 |
| Mr. Cratchit | 12 |
| Mr. Coward | 10 |
| Mr. Cottontail | 14 |
| Mr. Costello | 12 |
| Mr. Cooper, to us | 17 |
| Mr. Cooper ran out of thresher's storehouse (4) | 51 |
| Mr. Cooper in town | 18 |
| Mr. Cool's opposite | 23 |
| Mr. Connery | 11 |
| Mr. Cole | 8 |
| Mr. Clean? | 10 |
| Mr. Clean, in his superhero days? | 33 |
| Mr. Clean's lack | 20 |
| Mr. Clean would never part with one | 35 |
| Mr. Clean trademark | 19 |
| Mr. Clean target | 16 |
| Mr. Clean rival | 15 |
| Mr. Clean maker, for short | 26 |
| Mr. Clean alternative | 21 |
| Mr. Claus | 9 |
| Mr. Christian's skipper | 27 |
| Mr. Christian's ship | 24 |
| Mr. Christian's crime | 25 |
| Mr. Chips's class in "Goodbye, Mr. Chips" | 55 |
| Mr. Chips's charges | 23 |
| Mr. Chips' chips | 20 |
| Mr. Chips portrayer, 1969 | 25 |
| Mr. Chips portrayer Robert | 26 |
| Mr. Chips portrayer | 19 |
| Mr. Chips player | 16 |
| Mr. Chips et al. | 16 |
| Mr. Chekov of "Star Trek" | 35 |
| Mr. Chaney | 10 |
| Mr. Cat | 7 |
| Mr. Cassini | 11 |
| Mr. Carnegie | 12 |
| Mr. Carmen Electra, for 9 days | 30 |
| Mr. Capote, to his pals | 23 |
| Mr. Capote, to his friends | 26 |
| Mr. Capote, informally | 22 |
| Mr. Capote, for short | 21 |