| Big part of an elephant | 23 |
| Big part of California? | 23 |
| Big part of magazine income | 27 |
| Big party for jalopy owners? | 28 |
| Big payroll service co. | 23 |
| Big pharma name, for short | 26 |
| Big Pharma regulating org. | 26 |
| Big Pharma's output | 23 |
| Big Pharma's overseer | 25 |
| Big piece of artillery | 22 |
| Big piece of meat loaf | 22 |
| Big pistol manufacturer | 23 |
| Big place in California | 23 |
| Big play for an NFL D-back | 26 |
| Big player in the Suez Crisis | 29 |
| Big Poison of baseball | 22 |
| Big Poison or Little Poison | 27 |
| Big poker player's wager | 28 |
| Big pol. campaign donor | 23 |
| Big pooches, familiarly | 23 |
| Big popcorn containers | 22 |
| Big potential difference | 24 |
| Big problem for a pilot | 23 |
| Big problem on a check | 22 |
| Big problems of some stars | 26 |
| Big producer of printers | 24 |
| Big quantity of juice? | 22 |
| Big quantity of, informally | 27 |
| Big question of 1980s TV | 24 |
| Big recipient of junk mail | 26 |
| Big record label, once | 22 |
| Big red clown features | 22 |
| Big red dog of kids' TV | 27 |
| Big Red Machine hustler | 23 |
| Big Red of horse racing | 23 |
| Big Red, in the N.C.A.A. | 24 |
| Big ref. works, for short | 25 |
| Big repair bill reaction | 24 |
| Big reptile, informally | 23 |
| Big reptiles, informally | 24 |
| Big rig devices, often | 22 |
| Big rig fixtures, for short | 27 |
| Big ring stone, slangily | 24 |
| Big rooters for Ohio State? | 27 |
| Big round hairdo, in slang | 26 |
| Big sandwich, for short | 23 |
| Big scale manufacturer | 22 |
| Big score on the floor | 22 |
| Big screen film format | 22 |
| Big Seattle philanthropist | 26 |
| Big section in a dictionary | 27 |
| Big section of a dictionary | 27 |
| Big section of the dictionary | 29 |
| Big sections of dictionaries | 28 |
| Big seller for Chris Rock | 25 |
| Big seller in bear markets | 26 |
| Big seller in bear markets? | 27 |
| Big seller of acetaminophen | 27 |
| Big seller of smoothies | 23 |
| Big seller, supposedly | 22 |
| Big shot in ice hockey | 22 |
| Big shot in the Mideast | 23 |
| Big shot in the office | 22 |
| Big shot on Al Jazeera | 22 |
| Big shot with the bucks | 23 |
| Big shot's big wheels | 25 |
| Big shot's opposite? | 24 |
| Big shot's transportation | 29 |
| Big shot's vehicle | 22 |
| Big shots they're not | 25 |
| Big shots' assistants | 25 |
| Big Sky conference team | 23 |
| Big social gathering, e.g. | 26 |
| Big song for Lionel Richie | 26 |
| Big source for modern slang | 27 |
| Big source of amazement | 23 |
| Big source of reality TV | 24 |
| Big source of state revenue | 27 |
| Big South American bird | 23 |
| Big South Conference college | 28 |
| Big Southwestern trombones? | 27 |
| Big Spanish celebration | 23 |
| Big spender's accessory | 27 |
| Big spender's offer | 23 |
| Big spender's opposite | 26 |
| Big spender's phrase | 24 |
| Big spender's roll | 22 |
| Big spender's stash | 23 |
| Big spender's woe? | 22 |
| Big splash at Seaworld | 22 |
| Big sports event sponsor | 24 |
| Big stars have Grammy ones | 26 |
| Big stat for Manny Ramirez | 26 |
| Big stationery letter: Abbr. | 28 |
| Big striped cat, in Spain | 25 |
| Big Sunday dinners, maybe | 25 |
| Big Super Bowl expense | 22 |
| Big supplier to Boeing | 22 |
| Big surname in baseball | 23 |
| Big sweater size: Abbr. | 23 |