| Two-player whist-like game | 26 |
| Two-ply molecular structure | 27 |
| Two-point football score | 24 |
| Two-point gridiron plays | 24 |
| Two-point plays in football | 27 |
| Two-point score | 15 |
| Two-point score in football | 27 |
| Two-point Scrabble tile | 23 |
| Two-point shot | 14 |
| Two-point throw in horseshoes | 29 |
| Two-pointer | 11 |
| Two-pointer in football | 23 |
| Two-pointer made with ease | 26 |
| Two-pointer of a sort | 21 |
| Two-pointer, the hard way | 25 |
| Two-pointers | 12 |
| Two-pointers in Scrabble | 24 |
| Two-pointers? | 13 |
| Two-position switch | 19 |
| Two-pronged | 11 |
| Two-pronged instrument | 22 |
| Two-pronged weapon | 18 |
| Two-Pulitzer biographer Robert | 30 |
| Two-purpose | 11 |
| Two-putts, often | 16 |
| Two-reel movie | 14 |
| Two-reeler about baseballer Darryl? | 35 |
| Two-reeler, e.g. | 16 |
| Two-rocker jam | 14 |
| Two-rod antenna | 15 |
| Two-run homer prerequisite | 26 |
| Two-run homer requirement | 25 |
| Two-run homer situation | 23 |
| Two-scoopers, e.g. | 18 |
| Two-screen cinema | 17 |
| Two-season "American Idol" judge DioGuardi | 52 |
| Two-seat two-wheeler | 20 |
| Two-seated bicycle | 18 |
| Two-seated carriage | 19 |
| Two-seated carriages | 20 |
| Two-seated wagon | 16 |
| Two-seater | 10 |
| Two-seater? | 11 |
| Two-seaters | 11 |
| Two-seaters or four-seaters, e.g.? | 34 |
| Two-seaters, maybe | 18 |
| Two-sevenths of the territories on a Risk board | 47 |
| Two-sided | 9 |
| Two-sided affair | 16 |
| Two-sided letter | 16 |
| Two-sidedness | 13 |
| Two-somes | 9 |
| Two-speaker system | 18 |
| Two-sport Sanders | 17 |
| Two-spot | 8 |
| Two-spot and six-spot? | 22 |
| Two-stage missile | 17 |
| Two-star | 8 |
| Two-star flag officer | 21 |
| Two-star performance? | 21 |
| Two-star system | 15 |
| Two-step direction, perhaps | 27 |
| Two-story apartment | 19 |
| Two-stripe soldier: Abbr. | 25 |
| Two-striper | 11 |
| Two-striper (abbr.) | 19 |
| Two-striper in the Army: Abbr. | 30 |
| Two-stripers (abbr.) | 20 |
| Two-stripers, e.g.: Abbr. | 25 |
| Two-stroke drumbeat | 19 |
| Two-stroke drumbeats | 20 |
| Two-sword | 9 |
| Two-syllable feet | 17 |
| Two-syllable foot | 17 |
| Two-syllable foot, in poetry | 28 |
| Two-syllable poetic foot | 24 |
| Two-syllable poetic unit | 24 |
| Two-syllable shout | 18 |
| Two-syllable unit | 17 |
| Two-tab dinners for two | 23 |
| Two-tailed flag | 15 |
| Two-team wrestling meets | 24 |
| Two-term governor and three-term senator from Nebraska | 54 |
| Two-term presidents' tenures, e.g. | 38 |
| Two-term presidents' terms, e.g. | 36 |
| Two-term prez | 13 |
| Two-terminal device | 19 |
| Two-terminal semiconductor | 26 |
| Two-thirds of 10% of DCCXCV | 27 |
| Two-thirds of a canine star | 27 |
| Two-thirds of a double-play combo | 33 |
| Two-thirds of a dozen | 21 |
| Two-thirds of a magnum | 22 |
| Two-thirds of a Three Tenors selection | 38 |
| Two-thirds of AOL | 17 |
| Two-thirds of D.D.E. | 20 |
| Two-thirds of D.I.Y. | 20 |
| Two-thirds of DIY | 17 |
| Two-thirds of dodeca- | 21 |
| Two-thirds of Earth | 19 |