| Two-masters | 11 |
| Two-match link | 14 |
| Two-medium, as some rescues | 27 |
| Two-mile-high capital | 21 |
| Two-mile-high city | 18 |
| Two-mile-high menace | 20 |
| Two-minute warning giver | 24 |
| Two-month-old kid | 17 |
| Two-musician ensemble | 21 |
| Two-nation European peninsula | 29 |
| Two-nation peninsula | 20 |
| Two-ninths of MMCCLIX | 21 |
| Two-note announcement | 21 |
| Two-note instrument | 19 |
| Two-note keyboard effect | 24 |
| Two-of-a-kind vessel | 20 |
| Two-Oscar actor | 15 |
| Two-Oscar actor who loved crosswords | 36 |
| Two-Oscar actress | 17 |
| Two-Oscar Hilary | 16 |
| Two-Oscar knight | 16 |
| Two-Oscar winner for 1979 | 25 |
| Two-Oscar winner for 1984 | 25 |
| Two-Oscar winner Foster | 23 |
| Two-Oscar winner of '91 | 27 |
| Two-Oscar winner Sean | 21 |
| Two-out actions: Abbr. | 22 |
| Two-outs-in-a-single-AB stats | 29 |
| Two-page ad | 11 |
| Two-page ads | 12 |
| Two-palms-down signal | 21 |
| Two-paneled paintings | 21 |
| Two-parent households | 21 |
| Two-part | 8 |
| Two-part answer | 15 |
| Two-part curves | 15 |
| Two-part David Bowie song from "Scary Monsters (and Super Creeps)" | 76 |
| Two-part drama by Shakespeare | 29 |
| Two-part drama that won two Best Play Tonys and a Best Miniseries Emmy | 70 |
| Two-part glove | 14 |
| Two-part glue | 13 |
| Two-part lake connected by the Strait of Tiquina | 48 |
| Two-part tile | 13 |
| Two-passenger carriage | 22 |
| Two-percent alternative | 23 |
| Two-performer act | 17 |
| Two-person | 10 |
| Two-person bands | 16 |
| Two-person basketball game | 26 |
| Two-person bike | 15 |
| Two-person board game | 21 |
| Two-person contest | 18 |
| Two-person conversation | 23 |
| Two-person country fair contest | 31 |
| Two-person cutting tool | 23 |
| Two-person David Mamet play | 27 |
| Two-person groups | 17 |
| Two-person log cutter | 21 |
| Two-person matchup on ice | 25 |
| Two-person pencil-and-paper game | 32 |
| Two-person plank | 16 |
| Two-person racing sled | 22 |
| Two-person ride | 15 |
| Two-person showdown | 19 |
| Two-person sled | 15 |
| Two-person starter home of note? | 32 |
| Two-person starter home? | 24 |
| Two-person table game | 21 |
| Two-person talks | 16 |
| Two-person teams | 16 |
| Two-person tool | 15 |
| Two-person trick-taking game | 28 |
| Two-piano piece | 15 |
| Two-piece | 9 |
| Two-piece bathing suit | 22 |
| Two-piece bedroom furniture | 27 |
| Two-piece chest | 15 |
| Two-piece fastening | 19 |
| Two-piece living room units | 27 |
| Two-piece outfit | 16 |
| Two-piece part | 14 |
| Two-piece piece | 15 |
| Two-piece pieces | 16 |
| Two-piece shooter, often | 24 |
| Two-piece suit | 14 |
| Two-piece suit that won't keep you warm | 43 |
| Two-piece suit's lack | 25 |
| Two-piece suit? | 15 |
| Two-piece suits | 15 |
| Two-piece suits? | 16 |
| Two-piece top | 13 |
| Two-piece wear | 14 |
| Two-piece? | 10 |
| Two-piecer top | 14 |
| Two-pipped cards | 16 |
| Two-player activity | 19 |
| Two-player basketball game | 26 |
| Two-player card game | 20 |
| Two-player hoops game | 21 |
| Two-player logic game with colored pegs | 39 |