| Twitter.com messages | 20 |
| Twittering bird | 15 |
| Twittering Machine artist | 29 |
| Twittering Machine artist | 28 |
| Twittering mammal | 17 |
| Twittering with expectation | 27 |
| Twittering with rumors | 22 |
| Twitterpated | 12 |
| Twittery | 8 |
| Twitting remark | 15 |
| Twitty's "It's ____ Make Believe" | 51 |
| Twix candy maker | 16 |
| Twix maker | 10 |
| Twix or Trix, e.g. | 18 |
| Twix units | 10 |
| Twixt | 5 |
| Twixt 12 and 20 | 15 |
| Twixt L and P | 13 |
| Twixt's kin | 15 |
| Twixt's partner | 19 |
| Twizzlers competitor | 20 |
| Twizzlers licorice brand | 24 |
| Two | 3 |
| Two cubed | 10 |
| Two in Toulouse | 16 |
| Two ''G'' nations | 33 |
| Two "el"s | 19 |
| Two "King Lear" characters | 36 |
| Two "Lincolns" | 24 |
| Two "Monday, Monday" singers | 38 |
| TWO "UNITED" STATES | 29 |
| Two (Sp.) | 9 |
| Two (with "a") | 24 |
| Two --- kind | 12 |
| Two ... | 7 |
| Two ... two ... two mints in one | 32 |
| Two 10s, e.g. | 13 |
| Two aces, in dice | 17 |
| Two actors | 10 |
| Two actors make an "Albert" sandwich | 46 |
| Two actresses | 13 |
| Two actresses and a trumpeter | 29 |
| Two add up to two | 17 |
| Two adjectives applied to roads? | 32 |
| Two after do | 12 |
| Two after epsilon | 17 |
| Two after tee | 13 |
| Two after the news | 18 |
| Two after Tue. | 14 |
| Two and one | 11 |
| Two and three, for two | 22 |
| Two and three: Abbr. | 20 |
| Two are better than one | 23 |
| Two are often divided here | 26 |
| Two are often prescribed | 24 |
| Two are often put in | 20 |
| Two are taboo | 13 |
| Two Arnazes | 11 |
| Two Arthurian lasses | 20 |
| Two aspirin e.g. | 17 |
| Two aspirin, e.g. | 17 |
| Two aspirin, for instance | 25 |
| Two aspirin, say | 16 |
| Two aspirins, e.g. | 18 |
| Two aspirins, for instance | 26 |
| Two aspirins, say | 17 |
| Two at a table | 14 |
| Two at a time | 13 |
| Two at the wedding | 18 |
| Two authors and another author | 30 |
| Two bags of groceries, say | 26 |
| Two barbershop quartets | 23 |
| Two baseball teams | 18 |
| Two before Charlie | 18 |
| Two before do | 13 |
| Two before iota | 15 |
| Two before marzo | 16 |
| Two before two? | 15 |
| Two before X | 12 |
| Two behind em | 13 |
| Two bells on the afternoon watch | 32 |
| Two bells, at sea | 17 |
| Two bells, in a sailor's middle watch | 41 |
| Two bells, in the Navy | 22 |
| Two bells, on the middle watch | 30 |
| Two bells, perhaps | 18 |
| Two bells, to bosuns | 20 |
| Two below par | 13 |
| Two below par, to Nicklaus | 26 |
| Two birds named for their calls | 31 |
| TWO BITS | 8 |
| Two bits is 25 of these | 23 |
| Two books after Samuel: Abbr. | 29 |
| Two boots | 9 |
| Two bottled liquids kept in a cabinet? | 38 |
| Two Buckeye burgs | 17 |
| Two bucks, on Mediterranean Avenue | 34 |
| Two by four? | 12 |
| Two by two | 10 |
| Two by two? | 11 |