| Mr. Spock's irises? | 23 |
| Mr. Spock's had a point | 27 |
| Mr. Spock's forte | 21 |
| Mr. Spock's father in "Star Trek" | 47 |
| Mr. Spock portrayer Nimoy | 25 |
| Mr. Spock portrayer | 19 |
| Mr. Spielberg | 13 |
| Mr. Speaker | 11 |
| Mr. Spassky | 11 |
| Mr. Spacely's first name on "The Jetsons" | 55 |
| Mr. Sondheim | 12 |
| Mr. Solo | 8 |
| Mr. Smithers, e.g. | 18 |
| Mr. Smith who went to Wash., e.g. | 33 |
| Mr. Smith portrayer | 19 |
| Mr. Slate, to Fred Flintstone | 29 |
| Mr. Six-Pack | 12 |
| Mr. Simpson | 11 |
| Mr. Sikorsky | 12 |
| Mr. Shostakovich | 16 |
| Mr. Shoemaker's goal | 24 |
| Mr. Sheep | 9 |
| Mr. Sharif | 10 |
| Mr. Shankar | 11 |
| Mr. Serling | 11 |
| Mr. Scrooge | 11 |
| Mr. Scratch | 11 |
| Mr. Scott | 9 |
| Mr. Scissorhands | 16 |
| Mr. Schindler | 13 |
| Mr. Sandman's material | 26 |
| Mr. Sajak | 9 |
| Mr. Sadat | 9 |
| Mr. Saarinen | 12 |
| Mr. Rubinstein | 14 |
| Mr. Rubik | 9 |
| Mr. Royce's partner | 23 |
| Mr. Rosewater in Kurt Vonnegut's "God Bless You, Mr. Rosewater" | 77 |
| Mr. Root | 8 |
| Mr. Rogers's zippered sweater | 33 |
| Mr. Rogers' first name | 26 |
| Mr. Rogers was spotted here | 27 |
| Mr. Rogers was a Navy Seal, e.g. | 32 |
| Mr. Rogers trademark | 20 |
| Mr. Rogers on a horse | 21 |
| Mr. Rogers and others | 21 |
| Mr. Rogers | 10 |
| Mr. Rochester's ward | 24 |
| Mr. Roberts portrayer | 21 |
| Mr. Roberts | 11 |
| Mr. Robbins who partnered with Burt Baskin | 42 |
| Mr. Ripken | 10 |
| Mr. Right, with "the" | 31 |
| Mr. Right, say | 14 |
| Mr. Right, hopefully | 20 |
| Mr. Right, e.g. | 15 |
| Mr. Right | 9 |
| Mr. Rhodes of Rhodesia | 22 |
| Mr. Rhodes of Rhodes scholarships | 33 |
| Mr. Republican | 14 |
| Mr. Renee Zellweger, for 225 days | 33 |
| Mr. Reliable-in-a-crisis | 24 |
| Mr. Redding after making it big? | 32 |
| Mr. Rebozo | 10 |
| Mr. Ray | 7 |
| Mr. Rathbone | 12 |
| Mr. Quayle | 10 |
| Mr. Pulver, for ex. | 19 |
| Mr. Pulver's rank | 21 |
| Mr. Pulitzer | 12 |
| Mr. Public | 10 |
| Mr. Prokofiev | 13 |
| Mr. Pricklepants in "Toy Story 3," e.g. | 49 |
| Mr. Previn | 10 |
| Mr. Preminger | 13 |
| Mr. Power | 9 |
| Mr. Pound | 9 |
| Mr. Potato Head, for example | 28 |
| Mr. Potato Head stick-on | 24 |
| Mr. Potato Head pieces | 22 |
| Mr. Potato Head piece | 21 |
| Mr. Potato Head parts | 21 |
| Mr. Potato Head part | 20 |
| Mr. Potato Head pair | 20 |
| Mr. Potato Head maker | 21 |
| Mr. Potato Head gave his up | 27 |
| Mr. Potato Head features | 24 |
| Mr. Potato Head attachment | 26 |
| Mr. Potato Head and G.I. Joe | 28 |
| Mr. Potato Head accessory | 25 |
| Mr. Polo | 8 |
| Mr. Politically Incorrect | 25 |
| Mr. pluralized | 14 |
| Mr. Pitt | 8 |
| Mr. Pinza | 9 |
| Mr. Pim's creator | 21 |
| Mr. Pike of peak fame | 21 |
| Mr. Piggy's place | 21 |
| Mr. Piggy remark | 16 |
| Mr. Piggy | 9 |