| Major miner concern? | 20 |
| Major milk maker | 16 |
| Major military muff | 19 |
| Major military headquarters | 27 |
| Major midwestern airport | 24 |
| Major Middle Eastern airline | 28 |
| Major microcredit organization | 30 |
| Major Mexican seaport | 21 |
| Major Mexican drug cartel, with "los" | 47 |
| Major messes | 12 |
| Major mess | 10 |
| Major melees | 12 |
| Major medieval nutrition source | 31 |
| Major medical grp. | 18 |
| Major mattress maker | 20 |
| Major market for U.S. exports | 29 |
| Major marbles | 13 |
| Major manufacturing continent | 29 |
| Major malfunction | 17 |
| Major maker of water filters | 28 |
| Major maker of ovens | 20 |
| Major maker of beverage cans | 28 |
| Major Maine retailer | 20 |
| Major Maine merchant | 20 |
| Major mail handler?: Abbr. | 26 |
| Major mafioso | 13 |
| Major mafiosi | 13 |
| Major loss, figuratively | 24 |
| Major London insurer | 20 |
| Major lobbyist against generic drugs | 36 |
| Major line | 10 |
| Major Libyan export | 19 |
| Major lending org. after the subprime mortgage crisis | 53 |
| Major leagues, slangily, with "the" | 45 |
| Major leagues, slangily | 23 |
| Major leagues, in slang | 23 |
| Major leagues, in baseball slang | 32 |
| Major leagues, in baseball lingo | 32 |
| Major leagues | 13 |
| Major leaguers? | 15 |
| Major leaguers, e.g. | 20 |
| Major leaguers, 1969-2004 | 25 |
| Major leaguers | 14 |
| Major leaguer, e.g. | 19 |
| Major leaguer who played in parts of five decades | 49 |
| Major Leaguer Stephen or J.D. | 29 |
| Major leaguer or golf instructor | 32 |
| Major Leaguer Moises | 20 |
| Major leaguer in orange and black | 33 |
| Major leaguer in Canada | 23 |
| Major leaguer | 13 |
| Major league: Abbr. | 19 |
| Major league, slangily | 22 |
| Major League work stoppage | 26 |
| Major League V.I.P.'s | 25 |
| Major league swap | 17 |
| Major League stadium | 20 |
| Major League player before moving to S.F. | 41 |
| Major League pitcher, e.g. | 26 |
| Major league pitcher Car-los | 28 |
| Major League misplays | 21 |
| Major League manager Larry | 26 |
| Major League league: Abbr. | 26 |
| Major league family surname | 27 |
| Major league family name | 24 |
| Major league career? | 20 |
| Major league brothers' name | 31 |
| Major League bird | 17 |
| Major League Baseball's oldest rookie ever | 46 |
| Major League Baseball V.I.P. | 28 |
| Major League Baseball Players Association director | 50 |
| Major League Baseball family name | 33 |
| Major League Baseball commissioner Bud | 38 |
| Major League Baseball commissioner | 34 |
| Major League Baseball announcement recognizing top performance | 62 |
| Major league ball team | 22 |
| Major leader? | 13 |
| Major Lazer "___ Me" | 30 |
| Major lang. | 11 |
| Major landmass | 14 |
| Major landing site | 18 |
| Major land mass | 15 |
| Major label broken up in 2012 | 29 |
| Major L.A. Avenue | 17 |
| Major klutzes | 13 |
| Major kitchen appliance | 23 |
| Major KFC supplier | 18 |
| Major keys? | 11 |
| Major key that uses all five black keys on a piano | 50 |
| Major key | 9 |
| Major Kenyan export | 19 |
| Major Kazakhstani export | 24 |
| Major Joppolo's town | 24 |
| Major Joppolo's post | 24 |
| Major John ___ | 14 |
| Major jerk | 10 |
| Major jazz label | 16 |
| Major Japanese seaport | 22 |
| Major Japanese city | 19 |
| Major Japanese carrier | 22 |