| Major work by Virgil | 20 |
| Major work | 10 |
| Major Winchester portrayer David Ogden | 38 |
| Major West German port | 22 |
| Major waterway of Eastern Europe | 32 |
| Major water line | 16 |
| Major W.W. II Japanese base on New Guinea | 41 |
| Major Vietnam port | 18 |
| Major video game franchise | 26 |
| Major vessel | 12 |
| Major vein | 10 |
| Major util. | 11 |
| Major US punk club of the 1970s | 31 |
| Major US metal processor | 24 |
| Major US defense contractor | 27 |
| Major urban rd. | 15 |
| Major upset, say | 16 |
| Major upset | 11 |
| Major unrest | 12 |
| Major undertakings | 18 |
| Major undertaking? | 18 |
| Major undertaking | 17 |
| Major under Custer | 18 |
| Major UK record label | 21 |
| Major U.S.oil hub | 17 |
| Major U.S./Mexico border crossing | 33 |
| Major U.S. Spanish-language daily | 33 |
| Major U.S. lake | 15 |
| Major U.S. farm export | 22 |
| Major U. S. river | 17 |
| Major U of M rival | 18 |
| Major TV network | 16 |
| Major TV maker | 14 |
| Major TV logo | 13 |
| Major TV broadcaster | 20 |
| Major TV brand | 14 |
| Major troubles | 14 |
| Major trial | 11 |
| Major transportation routes | 27 |
| Major transportation route | 26 |
| Major transition point | 22 |
| Major transgression | 19 |
| Major transformation | 20 |
| Major transfer spots | 20 |
| Major trailer | 13 |
| Major trading center of Arabia | 30 |
| Major tractor manufacturer | 26 |
| Major tourneys | 14 |
| Major tournaments for clergymen? | 32 |
| Major tourist draw | 18 |
| Major tin producer | 18 |
| Major tin exporter | 18 |
| Major time span | 15 |
| Major time periods | 18 |
| Major time period | 17 |
| Major thoroughfare | 18 |
| Major theater chain | 19 |
| Major Thai export | 17 |
| Major tests | 11 |
| Major test | 10 |
| Major tennis tourney | 20 |
| Major tennis events | 19 |
| Major tennis event | 18 |
| Major telescope maker | 21 |
| Major tech stock | 16 |
| Major tea source | 16 |
| Major target in Risk | 20 |
| Major talent agcy. | 18 |
| Major swag | 10 |
| Major surprise | 14 |
| Major supporters of the ACA | 27 |
| Major supply | 12 |
| Major suits | 11 |
| Major suit? | 11 |
| Major suit, briefly | 19 |
| Major suit | 10 |
| Major suffix? | 13 |
| Major suffix | 12 |
| Major successor | 15 |
| Major success | 13 |
| Major strikes | 13 |
| Major stretches | 15 |
| Major stretch | 13 |
| Major stress factor, it's said | 34 |
| Major stories | 13 |
| Major stores | 12 |
| Major steps | 11 |
| Major starter? | 14 |
| Major start? | 12 |
| Major star | 10 |
| Major staff changes | 19 |
| Major spans | 11 |
| Major Spanish river | 19 |
| Major Spanish port city | 23 |
| Major Spanish daily | 19 |
| Major span | 10 |
| Major source of the narcotic qat | 32 |
| Major source of baseball talent | 31 |
| Major skirmishes | 16 |
| Major silver exporter | 21 |