| First-aid kits of a sort | 24 |
| First-aid paraphernalia | 23 |
| First-anniversary gift | 22 |
| First-born of siblings | 22 |
| First-century coup victim | 25 |
| First-century Roman despot | 26 |
| First-century Roman emperor | 27 |
| First-century Roman leader | 26 |
| First-class flight amenity | 26 |
| First-class hotel offering | 26 |
| First-class, informally | 23 |
| First-class, so to speak | 24 |
| First-column bingo number | 25 |
| First-cousin's mom | 22 |
| First-day-of-class handout | 26 |
| First-day-of-Latin-class word | 29 |
| First-discovered asteroid | 25 |
| First-down requirement | 22 |
| First-ever NBA lottery pick | 27 |
| First-fl. tenant, often | 23 |
| First-floor apartment number | 28 |
| First-floor apartment, maybe | 28 |
| First-floor apartment, often | 28 |
| First-founded US capital | 24 |
| First-generation hearing aid | 28 |
| First-generation Japanese | 25 |
| First-grade instruction | 23 |
| First-in-line's line | 24 |
| First-known variable star | 25 |
| First-magnitude star in Virgo | 29 |
| First-name in baseball lore | 27 |
| First-of-the-month payment | 26 |
| First-person shooter of 1996 | 28 |
| First-quarter moon tide | 23 |
| First-quarter shipments? | 24 |
| First-quarter-moon tide | 23 |
| First-rate chastisement? | 24 |
| First-rate coffeehouse? | 23 |
| First-rate stand-up comic | 25 |
| First-rate, in British slang | 28 |
| First-rate, informally | 22 |
| First-rate, so to speak | 23 |
| First-rate, to Kipling | 22 |
| First-round KO strategy? | 24 |
| First-sight phenomenon | 22 |
| First-string athletic groups | 28 |
| First-stringers, collectively | 29 |
| First-term Clinton victory | 26 |
| First-time driver, often | 24 |
| First-time drivers, often | 25 |
| First-time pot smoker, maybe | 28 |
| First-time tux wearer, maybe | 28 |
| First-time voter, perhaps | 25 |
| First-year cadet (Var.) | 23 |
| First-year German verb | 22 |
| First-year J.D. candidate | 25 |
| First-year J.D. student | 23 |
| First-year law school class | 27 |
| First-year law student | 22 |
| First-year law students | 23 |
| First-year medical residents | 28 |
| First-year Spanish verb | 23 |
| First-year student, briefly | 27 |
| First-year West Pointer | 23 |
| First-___ (A.R.C. worker) | 25 |
| First; chief: Comb. form | 24 |
| Firstborn's heritage | 24 |
| Firth of Clyde, for one | 23 |
| Firth of Forth facilities? | 26 |
| Fiscal or academic follower | 27 |
| Fischer beat him in Reykjavik | 29 |
| Fischer's best man | 22 |
| Fischer's strength? | 23 |
| Fischer-Dieskau's songs | 27 |
| Fish + cheese sandwich | 22 |
| Fish also called a blue jack | 28 |
| Fish also called a largemouth | 29 |
| Fish also called a namaycush | 28 |
| Fish also called a skegger | 26 |
| Fish also called a sockeye | 26 |
| Fish also called mahimahi | 25 |
| Fish and chips fish, perhaps | 28 |
| Fish and chips side dish | 24 |
| Fish befriended by Gill | 23 |
| Fish by dragging a net | 22 |
| Fish catcher with prongs | 24 |
| Fish caught in the Baltic Sea | 29 |
| Fish cleaners, at times | 23 |
| Fish composed of music notes? | 29 |
| Fish contained in unadon | 24 |
| Fish eaten with bagels | 22 |
| Fish eggs, or a kind of deer | 28 |
| Fish for eels with a hook | 25 |
| Fish for or ferret out | 22 |
| Fish from a moving vessel | 25 |
| Fish from Dover, often | 22 |
| Fish having feeble teeth | 24 |
| Fish hawk's cousin | 22 |
| Fish hawks' cousins | 23 |
| Fish hawks' relatives | 25 |