| Series of lines, essentially | 28 |
| Series of messages, perhaps | 27 |
| Series of missed calls | 22 |
| Series of missed connections | 28 |
| Series of musical numbers? | 26 |
| Series of Nintendo games | 24 |
| Series of novels, maybe | 23 |
| Series of online posts | 22 |
| Series of ornamental loops | 26 |
| Series of performances | 22 |
| Series of postures, basically | 29 |
| Series of premises, in logic | 28 |
| Series of selling points | 24 |
| Series of turns: Abbr. | 22 |
| Series of violent episodes? | 27 |
| Series of watering troughs? | 27 |
| Series opener or finale? | 24 |
| Series set at Fort Courage | 26 |
| Series set in Las Vegas | 23 |
| Series set in So. Cal. | 22 |
| Series set on a cruise ship | 27 |
| Series staged at 30 Rock | 24 |
| Series standout, briefly | 24 |
| Series starter in Santiago | 26 |
| Series terminal, briefly | 24 |
| Series winners in 1934 | 22 |
| Series winners: 1969 and 1986 | 29 |
| Series with a Dey in court | 26 |
| Series with lots of homicides | 29 |
| Series with Sergeant Friday | 27 |
| Series with Smits and Dey | 25 |
| Series' test episode | 24 |
| Series-concluding abbr. | 23 |
| Series-curtailing abbr. | 23 |
| Series-long story line | 22 |
| Series-shortening abbr. | 23 |
| Serif or souci preceder | 23 |
| Serious and kind of scary | 25 |
| Serious argument components | 27 |
| Serious biker's machine | 27 |
| Serious discussion's lack | 29 |
| Serious drug cases, for short | 29 |
| Serious flu outbreak, e.g. | 26 |
| Serious Frisbee thrower? | 24 |
| Serious grilling by the cops? | 29 |
| Serious hwy. violation | 22 |
| Serious injury from fire | 24 |
| Serious Lewis Carroll topic | 27 |
| Serious offense against God | 27 |
| Serious religious dissents | 26 |
| Serious second thoughts | 23 |
| Serious social engagement | 25 |
| Serious social problem | 22 |
| Serious story for the stage | 27 |
| Serious thinker's diet? | 27 |
| Serious ward, for short | 23 |
| Serious-and-funny show | 22 |
| Seriously shun the public | 25 |
| Serjeants' ___, London | 26 |
| Serkin's instrument | 23 |
| Sermon deliverer (abbr.) | 24 |
| Sermon deliverer: Abbr. | 23 |
| Sermon listeners, at times | 26 |
| Sermon on the Mount component | 29 |
| Sermon on the Mount deliverer | 29 |
| Sermon on the Mount metaphor | 28 |
| Sermon starter or ender | 23 |
| Sermon subject, at times | 24 |
| Sermon subject, literally? | 26 |
| Sermon subject, sometimes | 25 |
| Sermon subjects, often | 22 |
| Sermon's conclusion? | 24 |
| Sermon's final word | 23 |
| Sermon's inspiration | 24 |
| Sermonizer's source | 23 |
| Sermonizers' subjects | 25 |
| Sermons originate from them | 27 |
| Serpent killed by Hercules | 26 |
| Serpent of Egyptian art | 23 |
| Serpent slain by Hercules | 25 |
| Serpent with a Zulu name | 24 |
| Serpent with many heads | 23 |
| Serpent with nine heads | 23 |
| Serpent's home in Genesis | 29 |
| Serpent's warnings | 22 |
| Serpentor's affiliation | 27 |
| Serpico biographer Peter | 24 |
| Serpico's biographer | 24 |
| Servant for taverns, e.g. | 25 |
| Servant freed by Prospero | 25 |
| Servant in the tropics | 22 |
| Servant of the future? | 22 |
| Servant's contraction | 25 |
| Servant's entrance | 22 |
| Serve a long term, say | 22 |
| Serve again, as a net ball | 26 |
| Serve as a bridge over | 22 |
| Serve as a reminder of | 22 |
| Serve as a temporary fix | 24 |
| Serve as an optical beam | 24 |