| The first man to fly in space twice | 35 |
| The first man in space | 22 |
| The first lover | 15 |
| The first letter of "tsar," in Cyrillic | 49 |
| The first letter of "circle" (but not the fourth) | 59 |
| The first letter of "cent," e.g. | 42 |
| The First Lady of Song, to fans | 31 |
| The first James Bond movie | 26 |
| The first James Bond film | 25 |
| The first installment | 21 |
| The first indication that I had one too many last night? | 56 |
| The first H in HRH, perhaps | 27 |
| The first glossy fabric? | 24 |
| The first four-minute mile, e.g.? | 33 |
| The first film it aired was "Gone with the Wind" | 58 |
| The first electric one was used in Paris in the 1870s | 53 |
| The first Cosby show | 20 |
| The first complete navigation of the Amazon was in search of this | 65 |
| The first chip, usually | 23 |
| The first century started when it ended | 39 |
| The first cardinal? | 19 |
| The first cardinal | 18 |
| The first canonical hour | 24 |
| The first C of CDC: abbr. | 25 |
| The first Bond girl | 19 |
| The first blank in the seafood restaurant sign "___ ___ season" | 73 |
| The first big brother | 21 |
| The first bad brother | 21 |
| The first B of B&B | 22 |
| The first Apple with an Intel chip | 34 |
| The first and last European colony in China | 43 |
| The first American woman in space | 33 |
| The first American to orbit the Earth | 37 |
| The first American in space | 27 |
| The first African-American woman in space | 41 |
| The first a in aka | 18 |
| The first "T" of TNT | 30 |
| The first "S" in S.S.R.: Abbr. | 40 |
| The first "S" in S.A.S.E. | 35 |
| The first "N" of CNN | 30 |
| The first "Mr. Shirley Temple" | 40 |
| The first "M" in MGM | 30 |
| The first "M" in M-G-M | 32 |
| The first "L" of L. L. Bean | 37 |
| The first "H" of H.H.S. | 33 |
| The first "H" in Hanukkah | 35 |
| The first "A" of A.A. Milne | 37 |
| The first "A" of A. A. Milne | 38 |
| The first "A" in N.A.A.C.P.: Abbr. | 44 |
| The first "a" in a k a | 32 |
| The first 'M' of MGM | 28 |
| The firmament | 13 |
| The Firm rapper | 15 |
| The fire station burned down, e.g. | 34 |
| The Finnish language | 20 |
| The Finn man | 12 |
| The finishing touch | 19 |
| The finish for Captain Nemo? | 28 |
| The finest | 10 |
| The finding of a Virgin Mary-shaped gummy candy, e.g. | 53 |
| The financial analyst brought ... | 33 |
| The final word, to theologists | 30 |
| The final word in storybooks | 28 |
| The final word | 14 |
| The final Mrs. Chaplin | 22 |
| The final frontier | 18 |
| The final drink that may truly be final | 39 |
| The final battle | 16 |
| The final analysis, in business | 31 |
| The final "Friends" episode, e.g. | 43 |
| The fin man? | 12 |
| The filthy weed, in Nice | 24 |
| The film-processing machine at the movie studio ... | 51 |
| The film industry | 17 |
| The film director ... | 21 |
| The film "Harry Potter," to the box office | 52 |
| The fill in "fill 'er up!" | 40 |
| The Fighting Tigers: Abbr. | 26 |
| The Fighting Tigers, for short | 30 |
| The Fighting Tigers, briefly | 28 |
| The Fighting Tigers of the Southeastern Conf. | 45 |
| The Fighting Irish's school | 31 |
| The Fight of the Century fighter | 32 |
| The fifth tire | 14 |
| The Fifth Republic since 1958 | 29 |
| The fifth of the Five Pillars of Islam | 38 |
| The fifth of April | 18 |
| The fifth Marx brother | 22 |
| The fifth Marx | 14 |
| The fifth letter of "garage," but not the first | 57 |
| The fifth is spare | 18 |
| The fifth is a spare | 20 |
| The fifth element | 17 |
| The fifth (of seven!) single off "Thriller" | 53 |
| The Field Museum's Sue, e.g. | 32 |
| The fibre of the gomuti palm | 28 |
| The Festive State? | 18 |
| The feminine side, in Chinese circles | 37 |
| The feminine side | 17 |
| The female gamete | 17 |