| The same, in Sauternes | 22 |
| The same, mathematically | 24 |
| The same, on prescriptions | 26 |
| The same, on the Seine | 22 |
| The San Diego Chicken, e.g. | 27 |
| The Sandhill Stag, author | 25 |
| The Sandwich Islands, today | 27 |
| The Santa Maria landed here | 27 |
| The Say ___ Kid (Willie Mays) | 29 |
| The Scales of the zodiac | 24 |
| The Scales, astrologically | 26 |
| The Scales, to astrologers | 26 |
| The Scarecrow's need | 24 |
| The scariest bagel spread? | 26 |
| The scariest ones are near | 26 |
| The scarlet letter for one | 27 |
| The scarlet letter, e.g. | 24 |
| The scarlet letter, for one | 27 |
| The scenter of things? | 22 |
| The science of origins | 22 |
| The sclera covers most of it | 28 |
| The score in a classroom? | 25 |
| The screen's Jannings | 25 |
| The sea of Galilee, e.g. | 24 |
| The sea, to the French | 22 |
| The seas and the dwarfs, e.g. | 29 |
| The season to be jolly | 22 |
| The second cervical vertebra | 28 |
| The Second Coming writer | 27 |
| The second D of D&D | 23 |
| The second kind of, formally | 28 |
| The second Mrs. Perón | 24 |
| The second Mrs. Sinatra | 23 |
| The second Mrs. Tanqueray | 25 |
| The second number in a record | 29 |
| The second of January? | 22 |
| The second plague, in Exodus | 28 |
| The second Senator Bayh | 23 |
| The Secret Garden author | 24 |
| The Secret ____ : Conrad | 26 |
| The secretary brought ... | 25 |
| The sego lily is its flower | 27 |
| The Seine is full of it | 23 |
| The Seine, to Spaniards | 23 |
| The self-hypnotist ... | 22 |
| The Seminoles' sch. | 23 |
| The Seminoles, for short | 24 |
| The Senators' Zdena | 23 |
| The septum separates them | 25 |
| The seven daughters of Atlas | 28 |
| The Seven Dwarfs, at work | 25 |
| The Seven Dwarfs, e.g. | 22 |
| The seven of this puzzle | 24 |
| The seven-year problem | 22 |
| The sex lives of astronauts? | 28 |
| The Sex Pistols' genre | 26 |
| The Shadow's cover | 22 |
| The shallowest Great Lake | 25 |
| The shamrock is its symbol | 26 |
| The Sharks and the Jets, e.g. | 29 |
| The Sharks of Broadway, e.g. | 28 |
| The shay's motive power | 27 |
| The shoe __ the other foot | 26 |
| The short-tempered fellow ___ | 29 |
| The shortest of 12: Abbr. | 25 |
| The Sierra Club founder | 23 |
| The Sierras, e.g.: Abbr. | 24 |
| The signal with the sound | 25 |
| The Silence of the ____ | 23 |
| The Silver Bullet Band leader | 29 |
| The Silver State (Abbr.) | 24 |
| The Silver State, for short | 27 |
| The Silver State: Abbr. | 23 |
| The Simpsons and Popeye, e.g. | 29 |
| The Simpsons' neighbor | 26 |
| The sincerest of flattery | 25 |
| The singing voice, informally | 29 |
| The six days of the Creation | 28 |
| The sixth of Henry VIII | 23 |
| The size of ___ (itty-bitty) | 28 |
| The Skatalites' Jackie | 26 |
| The sky, it's said | 22 |
| The Skywalker boy, for short | 28 |
| The slope of y = x + 2 | 22 |
| The slow lane's side | 24 |
| The smallest little bit | 23 |
| The smallest unit of DNA | 24 |
| The smartest among us (var.) | 28 |
| The smartest Simpson kid | 24 |
| The smell of Geronimo? | 22 |
| The Smiths guitarist Johnny | 27 |
| The Smiths singer, to fans | 26 |
| The Smiths' dozer? | 22 |
| The Smithsonian, e.g. (Abbr.) | 29 |
| The Smithsonian, for ex. | 24 |
| The Smothers Brothers, e.g. | 27 |
| The Snake R. runs through it | 28 |
| The Snake snakes through it | 27 |
| The Sneetches' creator | 26 |
| The Snoopy ___-Cone Machine | 27 |