| Majolica glaze | 14 |
| Majolica item | 13 |
| Major | 5 |
| Major constellation | 20 |
| Major '40s box-office draw | 30 |
| Major 20's supplier? | 24 |
| Major 2000 political brouhaha | 29 |
| Major 2011 hurricane | 20 |
| Major 20th-cen. conflict | 24 |
| Major 70's acronym | 22 |
| Major A.T.M. manufacturer | 25 |
| Major account | 13 |
| Major accounts | 14 |
| Major achievement | 17 |
| Major Adams of "Wagon Train" and others | 49 |
| Major add-on | 12 |
| Major addition | 14 |
| Major addition? | 15 |
| Major adoption agcy. | 20 |
| Major advertising target | 24 |
| Major affair | 12 |
| Major affiliation | 17 |
| Major African conflict | 22 |
| Major African humanitarian concern of the 2000s | 47 |
| Major African language | 22 |
| Major African river | 19 |
| Major Air France terminus | 25 |
| Major airline | 13 |
| Major airline until 2001 | 24 |
| Major airport | 13 |
| Major airports | 14 |
| Major airports, e.g. | 20 |
| Major Alaskan gold rush city | 28 |
| Major Algerian port | 19 |
| Major alliance | 14 |
| Major alteration of a business structure, for short | 51 |
| Major aluminum producer | 23 |
| Major American export | 21 |
| Major American network | 22 |
| Major ancient construction project | 34 |
| Major and Blair, for short | 26 |
| Major and captain | 17 |
| Major and captain, e.g. | 23 |
| Major and Minor | 15 |
| Major and minor starter | 23 |
| Major and minor, in music | 25 |
| Major and private, e.g. | 23 |
| Major and rock endings | 22 |
| Major and usher followers | 25 |
| Major animal? | 13 |
| Major annoyance | 15 |
| Major annoyances | 16 |
| Major annual U.K. festival | 26 |
| Major apostle | 13 |
| Major appliance | 15 |
| Major apprehension | 18 |
| Major arteries | 14 |
| Major artery | 12 |
| Major artery in Philadelphia | 28 |
| Major artery through San Antonio | 32 |
| Major artery: Abbr. | 19 |
| Major Asian carrier, for short | 30 |
| Major assaults | 14 |
| Major at Columbia | 17 |
| Major at Cornell | 16 |
| Major Atlanta thoroughfare | 26 |
| Major Atlantic Ocean feeder | 27 |
| Major ATM maker | 15 |
| Major ATM manufacturer | 22 |
| Major attachment | 16 |
| Major attachment? | 17 |
| Major attar source | 18 |
| Major Aussie airport, on tags | 29 |
| Major Australian network | 24 |
| Major Australian watercourse | 28 |
| Major auto part | 15 |
| Major auto race, briefly | 24 |
| Major auto race, shortly | 24 |
| Major babe | 10 |
| Major Baltic port | 17 |
| Major banking center | 20 |
| Major Baroque composer | 22 |
| Major Baroque composer's monogram | 37 |
| Major Baroque composer's signature | 38 |
| Major baseball league | 21 |
| Major bashes | 12 |
| Major birth news | 16 |
| Major Black Sea port | 20 |
| Major blood carrier | 19 |
| Major blood conveyor | 20 |
| Major blood group | 17 |
| Major blood line | 16 |
| Major blood lines | 17 |
| Major blood supplier | 20 |
| Major blood vessel | 18 |
| Major blood vessels | 19 |
| Major bloodline | 15 |
| Major bloodline? | 16 |
| Major blows | 11 |
| Major blueberry-producing state | 31 |