| Southern U.S. forage plants | 27 |
| Southern tune often whistled | 28 |
| Southern tree | 13 |
| Southern treat | 14 |
| Southern tourist trail | 22 |
| Southern Togo native | 20 |
| Southern tobacco | 16 |
| Southern title-holder | 21 |
| Southern tip of South America | 29 |
| Southern tip of New Jersey | 26 |
| Southern terminus of I-35 | 25 |
| Southern taste treat | 20 |
| Southern talk | 13 |
| Southern sweet | 14 |
| Southern swarmer | 16 |
| Southern stretch? | 17 |
| Southern states | 15 |
| Southern state: Abbr. | 21 |
| Southern state symbol | 21 |
| Southern starch | 15 |
| Southern staples | 16 |
| Southern staple | 15 |
| Southern st. | 12 |
| Southern spud | 13 |
| Southern speech pattern | 23 |
| Southern speech feature | 23 |
| Southern speech | 15 |
| Southern specialty | 18 |
| Southern Spanish city | 21 |
| Southern soup ingredient | 24 |
| Southern soup | 13 |
| Southern sound | 14 |
| Southern soldier | 16 |
| Southern snappers, briefly | 26 |
| Southern Slavs | 14 |
| Southern Slav | 13 |
| Southern sky constellation | 26 |
| Southern site of an 1865 battle | 31 |
| Southern Sioux | 14 |
| Southern Siouans | 16 |
| Southern Signer | 15 |
| Southern side? | 14 |
| Southern side order | 19 |
| Southern side dish | 18 |
| Southern side | 13 |
| Southern sibling | 16 |
| Southern shrub | 14 |
| Southern shrine | 15 |
| Southern shouts | 15 |
| Southern shiner | 15 |
| Southern servings | 17 |
| Southern senator | 16 |
| Southern seabird | 16 |
| Southern sea | 12 |
| Southern school Martin Ritt attended | 36 |
| Southern sch. whose colors are purple and gold | 46 |
| Southern sandwich | 17 |
| Southern Sahara land | 20 |
| Southern Russian city | 21 |
| Southern roots | 14 |
| Southern river | 14 |
| Southern response | 17 |
| Southern resort city, briefly | 29 |
| Southern resort | 15 |
| Southern religious school | 25 |
| Southern region | 15 |
| Southern recipe direction | 25 |
| Southern rapper Young ___ | 25 |
| Southern rapper with a verse on Jay-Z's "Big Pimpin'" | 71 |
| Southern range | 14 |
| Southern R.S.V.P.? | 18 |
| Southern quick bread | 20 |
| Southern pronoun | 16 |
| Southern power provider: Abbr. | 30 |
| Southern power org. | 19 |
| Southern politician | 19 |
| Southern pod veggie | 19 |
| Southern pitcherful | 19 |
| Southern pine | 13 |
| Southern pie nut | 16 |
| Southern pie filling | 20 |
| Southern pie | 12 |
| Southern Pacific region | 23 |
| Southern Pacific and others: Abbr. | 34 |
| Southern Ontario town | 21 |
| Southern Ontario people | 23 |
| Southern Ontario community | 26 |
| Southern Ontario city | 21 |
| Southern oil center | 19 |
| Southern nuts | 13 |
| Southern nut | 12 |
| Southern novelist | 17 |
| Southern nickname, after "the" | 40 |
| Southern nickname | 17 |
| Southern NFLer | 14 |
| Southern NFL team | 17 |
| Southern New York, e.g. | 23 |
| Southern New Mexico county | 26 |
| Southern New Hampshire city | 27 |
| Southern neighbor of British Columbia | 37 |