| Only NL team never to have played in the World Series, briefly | 62 |
| Only non-Southern state won by the G.O.P. in '64 | 57 |
| Only one of the 13 Colonies not touching the Atl. Ocean | 55 |
| Only one of their members was actually born in Australia | 56 |
| Only Pacific Division NBA team not based in California | 54 |
| Only patron on "Cheers" to appear in all 275 episodes | 63 |
| Only person to guest-host "The Tonight Show With Jay Leno" | 68 |
| Only person to win Emmys for acting, writing and directing | 58 |
| Only person to win Oscars for acting and screenwriting | 54 |
| Only person to win two Nobels in two different sciences | 55 |
| Only person whose son and brother also won the Indianapolis 500 | 63 |
| Only pitcher of two consecutive no-hitters Johnny Vander ___ | 60 |
| Only place on Earth where crocodiles and alligators co-exist | 60 |
| Only player to appear in both the Super Bowl and World Series | 61 |
| Only player to be a part of three World Cup-winning teams | 57 |
| Only player to be part of three World Cup-winning teams | 55 |
| Only player to have back-to-back 50 point games in the NBA playoffs | 67 |
| Only player to hit 60 home runs in a season three times | 55 |
| Only player to hit an inside-the-park home run in the All-Star Game | 67 |
| Only player to win the World Series MVP without playing the field | 65 |
| Only positive integer that's neither prime nor composite | 60 |
| Only president who was selected by a congressional commission | 61 |
| Only president who'd been wounded in the Civil War | 54 |
| Only proper noun in the Beatles' "Revolution" | 59 |
| Only same-year N.C.A.A. and N.I.T. tourney winner (1950) | 56 |
| Only so-called "Decade Volcano" in the continental U.S. | 65 |
| Only solo artist to win back-to-back Record of the Year Grammys | 63 |
| Only South American nation whose official language is English | 61 |
| Only sport where the entire body is a legal target area | 55 |
| Only starting pitcher since 1971 to win a league M.V.P. award | 61 |
| Only state admitted under Grant's presidency: Abbr. | 55 |
| Only Steffi has spent more weeks as the #1 tennis player than her | 65 |
| Only surname shared by two different Best Actress Oscar winners | 63 |
| Only team besides the Yankees to win three consecutive World Series | 67 |
| Only three-time inductee to the Rock and Roll Hall of Fame | 58 |
| Only two U.S. states, Wash. and Cal., are entirely within this zone | 67 |
| Only U.S. president with a star on the Hollywood Walk of Fame | 61 |
| Only U.S. senator with a unit of measure named after him | 56 |
| Only US president to receive both a Purple Heart and a Pulitzer Prize | 69 |
| Only US president with a star on the Hollywood Walk of Fame | 59 |
| Only US state that can be typed on one row of the QWERTY keyboard | 65 |
| Only vegetable never sold frozen, canned, processed, or cooked | 62 |
| Only woman to win the top prize on "The $64,000 Question" | 67 |
| Only word containing three consecutive pairs of double letters | 62 |
| Only word spoken in Mel Brooks's "Silent Movie" | 61 |
| Onomatopoetic sound in KRS-One's "Sound of da Police" | 67 |
| Ontario town, or a Taurus between a Mustang and a Cougar? | 57 |
| Ookla the ___ ("Thundarr the Barbarian" character) | 60 |
| Opening in "Hollywood Squares," essentially | 53 |
| Opening movement of Holst's "The Planets" | 55 |
| Opening of "An Occurrence at Owl Creek Bridge"? | 57 |
| Opening scene locale in "Raiders of the Lost Ark" | 59 |
| Opening track of "The Beatles' Second Album" | 58 |
| Opening track on LL Cool J's "Bigger and Deffer" | 62 |
| Opening words of the Beatles' "We Can Work It Out" | 64 |
| Opening-round game of the N.C.A.A. basketball tournament | 56 |
| Opera about the steadfast wife of a political prisoner | 54 |
| Opera based on a play by Pierre Beaumarchais, with "The" | 66 |
| Opera based on Victor Hugo's "Le roi s'amuse" | 63 |
| Opera character who commits suicide by jumping off a parapet | 60 |
| Opera character who sings "Largo al factotum" | 55 |
| Opera character who sings “Vissi d’arte” | 52 |
| Opera featuring the "Prisoners' Chorus" | 53 |
| Opera heroine who sings "Einsam in trüben Tagen" | 61 |
| Opera heroine with the aria "Einsam in trüben Tagen" | 65 |
| Opera house that opened with "Faust" in 1883 | 54 |
| Opera made into a Broadway musical with an Elton John/Tim Rice score | 68 |
| Opera often paired with "Cavalleria Rusticana" | 56 |
| Opera singer Luisa whose name can be found on some menus | 56 |
| Opera singer who played Nellie on "Downton Abbey" | 59 |
| Opera tenor who attempts to rescue his lover from Hades | 55 |
| Opera that includes the "Prisoners' Chorus" | 57 |
| Opera that Leonard Bernstein began while on his honeymoon | 57 |
| Opera that the musical "Rent" was adapted from | 56 |
| Opera title character who hurls herself from a parapet | 54 |
| Opera title character who is stabbed by a spurned lover | 55 |
| Opera whose premiere was delayed by the Franco-Prussian War | 59 |
| Opera whose second act is called "The Gypsy" | 54 |
| Opera with the aria "Qui trarrò Cassio" | 52 |
| Operator of the largest brewery facility in the world | 53 |
| Operator represented by a downward arrow in symbolic logic | 58 |
| Operetta with Nanki-Poo and Yum-Yum, with "The" | 57 |
| Ophelia's niece, in "Uncle Tom's Cabin" | 57 |
| Opponent of Luther during the Protestant Reformation | 52 |
| Opponent of the O's in the "Beltway Series" | 57 |
| Oppressive measure that helped spark the French Revolution | 58 |
| Oprah's ''The Color Purple'' role | 53 |
| Oprah's character in "The Princess and the Frog" | 62 |
| Oprah's role in 2009's "The Princess and the Frog" | 68 |
| Optical illusion question, "Which is longer, ___?" | 60 |
| Option for those who are anti-Russian and anti-French? | 54 |
| Options strategy also known as a "buy-write" | 54 |
| Opus ___ ("The Da Vinci Code" organization) | 53 |
| Opus ___ (group depicted in "The Da Vinci Code") | 58 |
| Opus ___ (religious group featured in "The Da Vinci Code") | 68 |
| Orange drink on some of Portland's Voodoo Doughnuts | 55 |
| Orchestra member whose instrument rests on the floor | 52 |
| Orchestral piece that evokes some non-musical literature | 56 |
| Order between "ready" and "fire" | 52 |
| Order to a Nile reptile to upset a vessel? [1973/1974] | 54 |