| A smaller amount of | 19 |
| A smaller number | 16 |
| A smaller portion | 17 |
| A smartypants may have a big one | 32 |
| A smash might smash into it | 27 |
| A smattering of | 15 |
| A smidgen | 9 |
| A Smith | 7 |
| A smoked salmon | 15 |
| A smokeless tobacco | 19 |
| A smoker may flick it off | 25 |
| A smoker might bum one | 22 |
| A Smothers brother | 18 |
| A Smurf | 7 |
| A snake charmed her | 19 |
| A snake mackerel | 16 |
| A snake may swallow one whole | 29 |
| A snaky letter? | 15 |
| A snap | 6 |
| A snifter has a short one | 25 |
| A sniggler snares it | 20 |
| A sniggler's a giggler when he snares it | 44 |
| A snooze under a sombrero | 25 |
| A snowflake is one | 18 |
| A soc. sci. | 11 |
| A soccer player | 15 |
| A social | 8 |
| A social gathering | 18 |
| A social grace | 14 |
| A social sci. | 13 |
| A social stratum | 16 |
| A socially correct goose in Boston? | 35 |
| A socially correct goose? | 25 |
| A Society Island | 16 |
| A Socratic dialogue | 19 |
| A sodium carbonate | 18 |
| A soft cheese | 13 |
| A soft drink | 12 |
| A soft drink may have one | 25 |
| A soft place to dance | 21 |
| A soil fertilizer | 17 |
| A solar system "ice giant" | 36 |
| A soldier may swig from it | 26 |
| A soldier might get a medal for it | 34 |
| A soldier working in a mess? | 28 |
| A soldier's gear, for example | 33 |
| A sole might get caught in it | 29 |
| A solid | 7 |
| A solid alcohol | 15 |
| A solid caustic | 15 |
| A solid shaped like a doughnut | 30 |
| A solid-colored billiard ball | 29 |
| A solitary wasp was named after this actress | 44 |
| A solo dinger counts for one | 28 |
| A solo HR earns one | 19 |
| A solo shot gets you one: Abbr. | 31 |
| A somebody | 10 |
| A someday sow | 13 |
| A sometimes-blonde, e.g. | 24 |
| A son of Abraham | 16 |
| A son of Adam | 13 |
| A son of Aphrodite | 18 |
| A son of Aphrodite: Var. | 24 |
| A son of Apollo | 15 |
| A son of Ares | 13 |
| A son of Bela: 1 Chr. 7:7 | 25 |
| A son of Bilhah | 15 |
| A son of Boreas | 15 |
| A son of Caleb | 14 |
| A son of Cronus and Rhea | 24 |
| A son of Eliz. | 14 |
| A son of Eliz. II | 17 |
| A son of Eve | 12 |
| A son of Ezra | 13 |
| A son of Gad | 12 |
| A son of Gad: Gen. 46:16 | 24 |
| A son of Hera | 13 |
| A son of Hercules and Omphale | 29 |
| A son of Isaac | 14 |
| A son of Isaac and Rebecca | 26 |
| A son of Jacob | 14 |
| A son of Jacob and Israeli tribe | 32 |
| A son of Jacob and Leah | 23 |
| A son of Jacob and Zilpah | 25 |
| A son of Jacob: Var. | 20 |
| A son of Jaktan | 15 |
| A son of Japheth | 16 |
| A son of Jerahmeel | 18 |
| A son of Judah | 14 |
| A son of Juno | 13 |
| A son of Leah | 13 |
| A son of Leah and Jacob | 23 |
| A son of Lincoln | 16 |
| A son of Lot | 12 |
| A son of Mars | 13 |
| A son of Midian: I Chr. 1:33 | 28 |
| A son of Noah | 13 |
| A son of Nut | 12 |
| A son of Odin | 13 |
| A son of Odin: Var. | 19 |