| Main part of an elevator | 24 |
| Main part of an ocean | 21 |
| Main part of an order | 21 |
| Main part of Japan | 18 |
| Main part, often | 16 |
| Main part? | 10 |
| Main parts | 10 |
| Main parts of letters | 21 |
| Main point | 10 |
| Main points | 11 |
| Main port for grain from the Ukraine | 36 |
| Main port in Yemen | 18 |
| Main port of Iraq | 17 |
| Main port of Norway | 19 |
| Main port of Yemen | 18 |
| Main pronoun | 12 |
| Main protector | 14 |
| Main rat in "Ratatouille" | 35 |
| Main rd. | 8 |
| Main response? | 14 |
| Main river of Switzerland | 25 |
| Main road | 9 |
| Main role | 9 |
| Main role on "My Big Fat Greek Life" | 46 |
| Main roles | 10 |
| Main roof supports | 18 |
| Main route | 10 |
| Main route on the main (with an up-front charge) | 48 |
| Main route? | 11 |
| Main school team | 16 |
| Main seating area | 17 |
| Main section of a long poem | 27 |
| Main section of Venice | 22 |
| Main selection | 14 |
| Main shout | 10 |
| Main side of a coin | 19 |
| Main slot for disks | 19 |
| Main slot for memory sticks | 27 |
| Main song, recordwise | 21 |
| Main source of income | 21 |
| Main squeeze | 12 |
| Main squeeze's squeeze | 26 |
| Main St. brightener | 19 |
| Main St. light | 14 |
| Main stem of a plant | 20 |
| Main stem of a tree | 19 |
| Main stems | 10 |
| Main stream | 11 |
| Main street | 11 |
| Main Street beat? | 17 |
| Main Street establishments | 26 |
| Main Street event, maybe | 24 |
| Main Street for shoppers? | 25 |
| Main street in Peyton Place | 27 |
| Main Street liners | 18 |
| Main Street lineup | 18 |
| Main Street locales | 19 |
| Main Street merchant | 20 |
| Main Street sight | 17 |
| Main streets | 12 |
| Main subj. of a constitution | 28 |
| Main subject | 12 |
| Main takeaway | 13 |
| Main telephone connections | 26 |
| Main Theban deity | 17 |
| Main theme | 10 |
| Main thoroughfare | 17 |
| Main thoroughfare in Manhattan (one can be found in each of the four long answers in this puzzle) | 97 |
| Main thoroughfare through N.Y.C.'s Chinatown | 48 |
| Main threat | 11 |
| Main threat? | 12 |
| Main thrust | 11 |
| Main topic | 10 |
| Main transport? | 15 |
| Main trunk | 10 |
| Main trunks | 11 |
| Main vein | 9 |
| Main veins of leaves | 20 |
| Main vessel | 11 |
| Main vessel of a sea-going line | 31 |
| Main villain? | 13 |
| Main way in | 11 |
| Main Web page | 13 |
| Main website page | 17 |
| Main __ | 7 |
| Main ___ | 8 |
| Main ___ (boxing attraction) | 28 |
| Main ___ (street) | 17 |
| Main ___ (town hub) | 19 |
| Main, as a route | 16 |
| Main, e.g. | 10 |
| Main, Elm, etc.: Abbr. | 22 |
| Main, Hollywood and Vine (Abbr.) | 32 |
| Main, maybe | 11 |
| Main-course item | 16 |
| Main-event forerunner | 21 |
| Main-event preceder | 19 |
| Main-event preceder, briefly | 28 |
| Main-event warm-up | 18 |
| Maine | 5 |