| Main blood lines | 16 |
| Main blood vessel | 17 |
| Main bloodline | 14 |
| Main body | 9 |
| Main burden | 11 |
| Main burner? | 12 |
| Main cabinet mem. | 17 |
| Main call | 9 |
| Main campus site of the University of the South Pacific | 55 |
| Main cathedral area | 19 |
| Main cause | 10 |
| Main chambers | 13 |
| Main channel | 12 |
| Main character | 14 |
| Main character in "A Clockwork Orange" | 48 |
| Main character in "Enough Said" | 41 |
| Main character in "Hair" | 34 |
| Main character in "Pushing Daisies" | 45 |
| Main character in "Sex and the City" | 46 |
| Main character in "The Boondocks" | 43 |
| Main character in "The Chronicles of Narnia" | 54 |
| Main character in "The Little Mermaid" | 48 |
| Main character in "The Omen" | 38 |
| Main character in "The Paper Chase," e.g. | 51 |
| Main character in "The Vampire Chronicles" | 52 |
| Main character in "Up" | 32 |
| Main character in Elmer Rice's "The Adding Machine" | 65 |
| Main character in Hemingway's "Soldier's Home" | 64 |
| Main character in Proust's "Remembrance of Things Past" | 69 |
| Main character in the "Myst" series | 45 |
| Main character in the musical "Xanadu" | 48 |
| Main character in the video game "Assassin's Creed II" | 68 |
| Main character of "Slaughterhouse-Five" | 49 |
| Main character of "The Omen" | 38 |
| Main character of the 2010 film "Winter's Bone" | 61 |
| Main character of TV's "The Pretender" | 52 |
| Main character on "How I Met Your Mother" | 51 |
| Main character? | 15 |
| Main chip, for short | 20 |
| Main church area | 16 |
| Main church section | 19 |
| Main circuit card in a computer | 31 |
| Main city of ancient Phoenicia | 30 |
| Main city of Devon | 18 |
| Main city of the Negev | 22 |
| Main color of a Santa suit | 26 |
| Main communication channel | 26 |
| Main competitor of Betty Crocked? | 33 |
| Main component of chromosomes | 29 |
| Main component of Saturn's rings | 36 |
| Main component of vinegar | 25 |
| Main computer part (Abbr.) | 26 |
| Main conduit | 12 |
| Main consumer goods source, before 1750 | 39 |
| Main contents | 13 |
| Main contents of the Spanish | 28 |
| Main convention speaker | 23 |
| Main corporeal vessel | 21 |
| Main course | 11 |
| Main course at the first Thanksgiving | 37 |
| Main course in U.S. | 19 |
| Main course of a meal | 21 |
| Main course of study | 20 |
| Main course on Thanksgiving | 27 |
| Main course only | 16 |
| Main course? | 12 |
| Main courses | 12 |
| Main courses? | 13 |
| Main crew | 9 |
| Main deck | 9 |
| Main dedicatee of an Austin cathedral? | 38 |
| Main direction | 14 |
| Main dish | 9 |
| Main dish, often | 16 |
| Main dishes | 11 |
| Main drag | 9 |
| Main drag, e.g. | 15 |
| Main drag, for ex. | 18 |
| Main drags | 10 |
| Main element in pewter | 22 |
| Main engagement? | 16 |
| Main entrance | 13 |
| Main entrances? | 15 |
| Main et al. | 11 |
| Main et al: Abbr. | 17 |
| Main event in "The Crucible" | 38 |
| Main event preceder | 19 |
| Main event preceder, briefly | 28 |
| Main event preceder, for short | 30 |
| Main event setting | 18 |
| Main event venue | 16 |
| Main feature | 12 |
| Main feature of Venus de Milo | 29 |
| Main feature? | 13 |
| Main female character in "Swan Lake" | 46 |
| Main female characters | 22 |
| Main fin | 8 |
| Main foe in a movie? | 20 |
| Main food-supplying region of a country | 39 |
| Main force | 10 |